Plasma β-amyloid in mild behavioural impairment – neuropsychiatric symptoms on the Alzheimer’s continuum

Abstract

IntroductionSimple markers are required to recognize older adults at higher risk for neurodegenerative disease. Mild behavioural impairment (MBI) and plasma β-amyloid (Aβ) have been independently implicated in the development of incident cognitive decline and dementia. Here we studied the associations between MBI and plasma Aβ42/Aβ40.MethodsParticipants with normal cognition (n = 86) or mild cognitive impairment (n = 53) were selected from the Alzheimer’s Disease Neuroimaging Initiative. MBI scores were derived from Neuropsychiatric Inventory items. Plasma Aβ42/Aβ40 ratios were assayed using mass spectrometry. Linear regressions were fitted to assess the association between MBI total score as well as MBI domain scores with plasma Aβ42/Aβ40.ResultsLower plasma Aβ42/Aβ40 was associated with higher MBI total score (p = 0.04) and greater affective dysregulation (p = 0.04), but not with impaired drive/motivation (p = 0.095) or impulse dyscontrol (p = 0.29) MBI domains.ConclusionIn persons with normal cognition or mild cognitive impairment, MBI was associated with low plasma Aβ42/Aβ40. Incorporating MBI into case detection can help capture preclinical and prodromal Alzheimer’s disease.

Neuroimaging of mild behavioral impairment: A systematic review

“…13 In MCI with MBI, the HR for conversion to DLB (3.023) was the highest, followed by those for conversion to FTD (2.595) and AD (1.770). 13 Factors related to MBI include AD biomarkers, [14][15][16][17][18][19][20] brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, 21 cognitive impairment, [22][23][24][25] dual-task gait, 26 activities of daily living, 25 frailty, 27,28 diabetes mellitus, 29 low vitamin D, 30 high serum triglyceride, 30 hearing impairment, 31 and male gender. 28,[31][32][33] Many neuroimaging studies of MBI have also been performed, but the results are inconsistent.…”

Cognitive profile of people with mild behavioral impairment in Brain Health Registry participants

“…Mild behavioral impairment (MBI) is a pre-dementia neurobehavioral syndrome characterized by the de novo emergence and persistence of NPS in older adults representing a change from long-standing patterns of behavior (Ismail et al, 2016). MBI is associated with amyloid, tau, neurodegeneration, and AD risk genes (Andrews et al, 2018;Creese et al, 2021b;Gill et al, 2021;Johansson et al, 2021;Lussier et al, 2020;Matuskova et al, 2021;Miao et al, 2021;Naude et al, 2020;Ruthirakuhan et al, 2022), and a greater risk of incident cognitive decline and dementia (Creese et al, 2019;Gill et al, 2020;Ismail et al, 2021;Matsuoka et al, 2019;Taragano et al, 2018;Tsunoda et al, 2021;Wolfova et al, 2021). Incorporating MBI into screening may provide a complementary approach to early detection (Mortby et al, 2018).…”