Plasma α1-Acid Glycoprotein Can Be Used to Adjust Inflammation-Induced Hyporetinolemia in Vitamin A-Sufficient, but Not Vitamin A-Deficient or -Supplemented Rats

Gieng, John; Rosales, Francisco J.

doi:10.1093/jn/136.7.1904

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Glycosylation microheterogeneity of AGP can be modified during disease (Ceciliani and Pocacqua, 2007). The AGP can also be used to adjust inflammation-induced hyporetinolemia in vitamin A-sufficient animals (Gieng and Rosales, 2006). In addition, serum amyloid A is a family of proteins encoded in a multigene complex and is one of the acute-phase reactants in response to infection, inflammation, and trauma (Jensen and Whitehead, 1998).…”

Section: Discussionmentioning

confidence: 99%

Comparative proteomics analysis of plasma proteins during the transition period in dairy cows with or without subclinical mastitis after calving

Yang¹,

Wang²,

Bu³

et al. 2012

CZECH J ANIM SCI

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ABSTRACT:The transition period is the most critical time of the cow's lactation cycle that is associated with the onset of mastitis. In this study, changes of plasma proteins in cows (n = 12) with or without subclinical mastitis after calving were determined by two-dimensional electrophoresis (2-DE), which detected 18 spots with variations in protein spots abundance. These spots were identified by liquid chromatography coupled with tandem mass spectrometry. The changes in protein profile from day 21 before calving to day 1 after calving were similar in cows with or without subclinical mastitis. Abundance of α1 acid glycoprotein (AGP) and haptoglobin was dramatically increased at parturition, while transthyretin was down-regulated at parturition, and apolipoprotein E and immunoglobulin gamma 1 were up-regulated at postpartum compared with prepartum in periparturient dairy cows. In cows infected with subclinical mastitis, AGP, haptoglobin, and serum amyloid A were dramatically increased and continued to be elevated in plasma from day 1 to day 21 after calving compared with cows free of mastitis. Changes of protein in plasma at parturition may serve as an immune system response to parturition and lactation process at the protein level and suggest that these altered proteins would not serve as a potential marker for predicting if the periparturient dairy cows are susceptible to subclinical mastitis.

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Section: Discussionmentioning

confidence: 99%

Comparative proteomics analysis of plasma proteins during the transition period in dairy cows with or without subclinical mastitis after calving

Yang¹,

Wang²,

Bu³

et al. 2012

CZECH J ANIM SCI

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“…It has been shown that concentrations of serum retinol (SR), the commonly used biomarker of vitamin A status, 6 are reduced during the acute phase response to infections. [7][8][9][10] This phenomenon, referred to as inflammation-induced hyporetinolemia (IIH), [11][12][13][14] is not completely understood and may lead to misclassification of vitamin A status at the child and population levels.…”

Section: Introductionmentioning

confidence: 99%

Comparability of Inflammation-Adjusted Vitamin A Deficiency Estimates and Variance in Retinol Explained by C-Reactive Protein and α1-Acid Glycoprotein during Low and High Malaria Transmission Seasons in Rural Zambian Children

Barffour

Schulze

Coles

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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Inflammation-induced hyporetinolemia (IIH), a reduction in serum retinol (SR) during inflammation, may bias population estimates of vitamin A deficiency (VAD). The optimal adjustment for IIH depends on the type and extent of inflammation. In rural Zambian children (4-8 years, = 886), we compared three models for defining inflammation: α-1-acid glycoprotein (AGP) only (inflammation present if> 1 g/L or normal if otherwise), C-reactive protein (CRP) only (moderate inflammation, 5-15 mg/L; high inflammation, > 15 mg/L; or normal if otherwise) and a combined model using both AGP and CRP to delineate stages of infectious episode. Models were compared with respect to 1) the variance in SR explained and 2) comparability of inflammation-adjusted VAD estimated in low and high malaria seasons. Linear regression was used to estimate the variance in SR explained by each model and in estimating the adjustment factors used in generating adjusted VAD (retinol < 0.7 μmol/L). The variance in SR explained were 2% (AGP-only), 11% (CRP-only), and 11% (AGP-CRP) in the low malaria season; and 2% (AGP-only), 15% (CRP-only), and 12% (AGP-CRP) in the high malaria season. Adjusted VAD estimates in the low and high malaria seasons differed significantly for the AGP (8.2 versus 13.1%) and combined (5.5 versus 9.1%) models but not the CRP-only model (6.1 versus 6.3%). In the multivariate regression, a decline in SR was observed with rising CRP (but not AGP), in both malaria seasons (slope = -0.06; < 0.001). In this malaria endemic setting, CRP alone, as opposed to CRP and AGP, emerged as the most appropriate model for quantifying IIH.

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“…Furthermore, workers rarely measure AGP, so any influence of chronic inflammation on the data is ignored. Alternatively, regression analyses using the change in APP to predict the change in retinol ( 27 ) or ferritin ( 28 ) have also been unsuccessfully used as individual APP do not reflect exactly the behaviour of nutritional biomarkers throughout the period of inflammation especially in apparently healthy people. In the latter correlations between APP and nutritional biomarkers are poor and changes in APP explain very little of the variance in the nutritional biomarkers ( 28 ) .…”

Section: Discussionmentioning

confidence: 99%

Using plasma acute-phase protein concentrations to interpret nutritional biomarkers in apparently healthy HIV-1-seropositive Kenyan adults

et al. 2008

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Inflammation influences the assessment of nutritional status. For example, inflammation reduces plasma retinol concentrations and vitamin A deficiency is overestimated. Conversely inflammation increases plasma ferritin concentrations and Fe deficiency is underestimated. Blood samples were obtained from 163 free-living HIV-1-infected adults, not on continuous medication, anti-retroviral drugs or micronutrients, not unwell and who had not reached WHO stage IV of HIV/AIDS. We used four markers of inflammation, C-reactive protein (CRP), a1-acid glycoprotein (AGP), a1-antichymotrypsin and erythrocyte sedimentation rate but mainly CRP and AGP were used to separate the subjects into four groups: 'healthy' where both CRP and AGP were normal; 'incubation phase' where CRP was elevated; 'early convalescence' where AGP and CRP were elevated and 'late convalescence' where only AGP was elevated. Correction factors were calculated to remove the influence of inflammation from each biomarker and group where inflammation was present and the data are shown before and after recalculation. The correction increased median plasma retinol concentrations of the whole group from 1·16 to 1·33 mmol/l, comparable with values (mean 1·29 mmol/l) in HIV-negative Kenyan women. Median ferritin concentrations fell by about 50 % in both sexes and the number of women with plasma ferritin concentrations #12 mg/l increased from eleven to twenty. The correction also increased plasma carotenoids and Hb but not a-tocopherol concentrations. We suggest that the method described to remove the influence of inflammation from nutritional biomarkers should be generally applicable in apparently healthy people and prevents discarding valuable data because of mild inflammation. The method does now need to be tested in other populations.

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Plasma α1-Acid Glycoprotein Can Be Used to Adjust Inflammation-Induced Hyporetinolemia in Vitamin A-Sufficient, but Not Vitamin A-Deficient or -Supplemented Rats

Cited by 4 publications

References 34 publications

Comparative proteomics analysis of plasma proteins during the transition period in dairy cows with or without subclinical mastitis after calving

Comparative proteomics analysis of plasma proteins during the transition period in dairy cows with or without subclinical mastitis after calving

Comparability of Inflammation-Adjusted Vitamin A Deficiency Estimates and Variance in Retinol Explained by C-Reactive Protein and α1-Acid Glycoprotein during Low and High Malaria Transmission Seasons in Rural Zambian Children

Using plasma acute-phase protein concentrations to interpret nutritional biomarkers in apparently healthy HIV-1-seropositive Kenyan adults

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