Plasma Zinc, copper and copper/zinc ratio in intrinsic asthma

Kadrabová, J; Madăric, A; Podivínsky, F.; Gazdik, Frantisek; Ginter, E

doi:10.1016/s0946-672x(96)80008-3

Cited by 52 publications

(32 citation statements)

References 18 publications

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“…Overall, these observations would suggest that higher levels of copper in the blood are likely to contribute to the neutrophilic inflammation involved in the pathogenesis of COPD in humans (Barnes, 2000), rather than result from it (Boosalis et al, 1996). Alternatively, as high levels of serum copper have also been reported in asthma (Malvy et al, 1993;Kadrabova et al, 1996;Vural et al, 2000), in light of the studies cited above (Boosalis et al, 1996;Kennedy et al, 1998;Rice et al, 2001), it is also possible that increased plasma copper contributes to the accelerated decline in lung function observed in those with asthma (Lange et al, 1998).…”

Section: Coppermentioning

confidence: 89%

Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population

et al. 2005

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Background: Increased dietary intake of antioxidants has been associated with higher lung function, but few studies have used biological markers of antioxidant intake. Objective: This study aimed to determine if antioxidant status, as measured by blood levels, influences lung function. Design: Using a random subsample of 479 participants, aged 18-65 y old, from a larger cross-sectional observational study, the association of forced expiratory volume in 1 s (FEV 1 ) with plasma copper, vitamin C, vitamin E and serum selenium was assessed. Results: An s.d. increase in blood copper level was associated with a difference in FEV 1 of À48 ml (95% confidence intervals: À95, À2 ml, P ¼ 0.04), vitamin C þ 49 ml ( þ 4, þ 94, P ¼ 0.03), vitamin E À15 ml (À62, þ 32, P ¼ 0.53) and selenium þ 52 ml ( þ 7, þ 96, P ¼ 0.02). The sizes of association were not appreciably altered in a mutually adjusted model. Conclusions: Higher levels of serum vitamin C and selenium appear to be associated with higher FEV 1 . The association between higher serum copper and lower FEV 1 requires further study in view of the ubiquitous exposure to this mineral. Sponsorship: National Asthma Campaign and British Lung Foundation.

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Section: Coppermentioning

confidence: 89%

Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population

et al. 2005

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“…Deviations from the normal values of some metallic elements have been related to disorders or diseases as well as to environmental and nutritional factors [9,10]. Moreover, diseases or disorders may affect the bonding environment of various metallic inorganic elements in the nail, as it is observed in the case of Fe in neuron tissues [11].…”

Section: Introductionmentioning

confidence: 99%

Zn-K edge EXAFS study of human nails

Katsikini

Mavromati

Pinakidou

et al. 2009

J. Phys.: Conf. Ser.

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Abstract. Extended X-ray absorption fine structure (EXAFS) spectroscopy at the Zn -K edge is applied for the study of the bonding geometry of Zn in human nails. The studied nail clippings belong to healthy donors and donors who suffer from lung diseases. Fitting of the first nearest neighboring shell of Zn reveals that it is bonded with N and S, at distances that take values in the ranges 2.00-2.04 Å and 2.23-2.28Å, respectively. Zn is four -fold coordinated and the ratio of the number of sulfur and nitrogen atoms (Ν S /N Ν ) in the first coordination shell ranges from 0.52 to 1. The sample that belongs to the donor who suffers from lung fibrosis, a condition that is related to keratinization of the lung tissue, is characterized by the highest number of Ν S /N Ν . Simulation, using the FEFF8 code, of the Zn -K edge EXAFS spectra with models of tetrahedrally coordinated Zn with 1 (or 2) cysteine and 3 (or 2) histidines is satisfactory.

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“…Several studies have reported an association between asthma and low hair and serum Zn levels (13)(14)(15)(16)(17). In another study, a negative relationship was found between wheezing and serum Zn:Cu ratio in a large population within the United States ( n ϭ 9,074) (18).…”

mentioning

confidence: 99%

Altered Zinc Homeostasis and Caspase-3 Activity in Murine Allergic Airway Inflammation

Truong-Tran

Ruffin

Foster

et al. 2002

Am J Respir Cell Mol Biol

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Zn may have an important protective role in the respiratory epithelium and Zn deficiency may enhance airway inflammation and epithelial damage. The effects of mild nutritional Zn deficiency on airway hyperresponsiveness (AHR) and airway inflammation in mice sensitized and challenged with ovalbumin (OVA) to induce an allergic response were investigated. Balb/c mice were given Zn normal (ZN, 50 mg/kg Zn) or Zn limited diets (ZL, 14 mg/kg Zn) before and during induction of allergic airway inflammation, with appropriate controls (saline-treated, SAL). ZL mice had greater levels of AHR than ZN mice, regardless of presence or absence of allergic inflammation. These mice also had increased eosinophilia and mucus cell hyperplasia compared with ZN mice. Second, ZN and ZL OVA-treated mice had significant decreases in airway epithelial Zinquin fluorescence, indicating a lowered availability of Zn compared with their SAL-treated counterparts. In contrast, the pro-apoptotic protein caspase-3, which was co-localized with Zn in the apical epithelium, was significantly increased in both ZN and ZL OVA-treated mice. Immunologically active caspase-3 and apoptosis were increased in OVA-treated mice, especially the ZL group. These findings provide the first data for adverse effects of Zn deficiency on the respiratory epithelium and support a role for altered Zn homeostasis and caspase upregulation in asthma.

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Plasma Zinc, copper and copper/zinc ratio in intrinsic asthma

Cited by 52 publications

References 18 publications

Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population

Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population

Zn-K edge EXAFS study of human nails

Altered Zinc Homeostasis and Caspase-3 Activity in Murine Allergic Airway Inflammation

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