Plasma Zinc and Copper in Diabetes Mellitus

Pidduck, Heather; Wren, Peter J J; Evans, David A.

doi:10.2337/diab.19.4.234

Cited by 40 publications

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“…Serum levels reported in the literature have ranged from normal [11,12] to higher than normal [13] , whereas copper levels observed in the body were altered; for instance, levels in the muscles are lower than in controls in all cases. The disagreement in the values recorded here may be ascribable to differences in the intake of this element, to higher excretion rates, or to differing prevalence rates for the various metabolic complications.…”

Section: Discussionmentioning

confidence: 96%

Plasma Mineral Content in Type-2 Diabetic Patients and Their Association with the Metabolic Syndrome

Aguilar

Saavedra‐García

Arrieta³

et al. 2007

Ann Nutr Metab

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Background: Metabolic syndrome is a clinical disorder that is becoming more prevalent in Spain. The syndrome encompasses a set of metabolic disorders such as type-2 diabetes mellitus, hypertension, dyslipidemia, and obesity, which may be associated with variations in serum levels and poor delivery of certain mineral elements. Methods: This study attempted to ascertain whether metabolic syndrome might be linked to alterations in serum levels of the mineral elements magnesium, copper, zinc, chromium, and nickel in a population of 92 diabetic subjects, some suffering from certain conditions associated with the metabolic syndrome, and 72 control subjects (Hospital Príncipe de Asturias, Alcalá de Henares, Spain). Results: The results indicated that as a group the alterations implicated in metabolic syndrome were indeed associated with variations in blood levels of the mineral elements considered, though statistically significant differences were recorded only in the case of copper. Still, trends in mineral levels for each of the separate components contributing to the syndrome tended to increase. Conclusion: Metabolic complications appear to be associated with alterations in the levels of some minerals, especially copper.

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Section: Discussionmentioning

confidence: 96%

Plasma Mineral Content in Type-2 Diabetic Patients and Their Association with the Metabolic Syndrome

Aguilar

Saavedra‐García

Arrieta³

et al. 2007

Ann Nutr Metab

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“…Other studies found that in diabetic patients, circulating copper concentrations were not different (21) or were greater in patients with chronic complications or macrovascular diseases (4). Indeed, in the presence of overt diabetes with chronic complications, the associated chronic low-grade inflammatory state might be responsible for an increase in blood copper concentrations.…”

Section: Discussionmentioning

confidence: 99%

Associations of Dietary and Serum Copper with Inflammation, Oxidative Stress, and Metabolic Variables in Adults ,

Durazzo

Gambino

et al. 2008

The Journal of Nutrition

150

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There are conflicting data on the associations between copper and glycemia, plasma lipids, and atherosclerotic diseases.Copper has both pro-oxidant and antioxidant effects. We performed a cross-sectional analysis to investigate the associations between dietary copper intake and metabolic variables and serum high-sensitivity C-reactive protein (hs-CRP) in asymptomatic subjects from a population-based cohort (n ¼ 1197) and between serum copper concentration and markers of oxidative stress, including plasma nitrotyrosine (NT) and total antioxidant status (TAS), hs-CRP, and metabolic variables in a subgroup of men from this cohort (n ¼ 231). In all subjects, diastolic blood pressure and circulating glucose, uric acid, and total and LDL-cholesterol concentrations significantly decreased, whereas the hs-CRP concentration increased, from the lowest to the highest tertile of copper intake. In the male subgroup, glucose and total and LDL-cholesterol and TAS decreased, whereas hs-CRP and NT concentrations increased from the lowest to the highest tertile of serum copper concentration. In multiple regression models, dietary copper intake was inversely associated with diastolic blood pressure (P ¼ 0.002), fasting glucose (P , 0.001), total cholesterol (P , 0.001), LDL-cholesterol (P , 0.001), and uric acid (P , 0.001) and was directly associated with the hs-CRP concentration (P , 0.001). Serum copper concentrations were inversely associated with glucose (P , 0.001), total cholesterol (P , 0.001), LDL-cholesterol (P , 0.001), and TAS (P , 0.001) and were directly associated with hs-CRP (P , 0.001) and NT concentrations (P , 0.001). Marginal copper deficiency is associated with an unfavorable metabolic pattern, but copper supplementation might not be recommended in view of its association with inflammation and markers of oxidative stress.

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“…bei Alkoholikern [20,56], Leberzirrhosen [41,56,63,64], renalen Erkrankungen [62], Sichelzellenan/imie [42], Verbrennungen [10,21], Infektionskrankheiten [1] oder anderen Typen von Entzfindungen und Verletzungen [11,29] beobachtet werden konnte. Einige Patienten mit Diabetes mellitus zeigten ebenfalls eine erh6hte renale Ausscheidung von Zink [37,58], wobei der Plasma-Zn-Gehalt aber unverfindert blieb [36]. Auch die erh6hte Ausscheidung yon Sulfat oder Harnstoff erfolgt erst im weit fortgeschrittenen Stadium des Zn-Mangels und ist daher ftir die Erfassung eines marginalen Zn-Status nicht geeignet [13].…”

Section: Bei Den Jungenunclassified

Experimentelle Untersuchungen zur Diagnose von marginalem Zinkmangel

Roth

Kirchgeßner

1979

Res. Exp. Med.

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Experimental Studies on the Diagnosis of Marginal Zinc DeficiencySummary. A hundred and twelve male Sprague-Dawley rats with an average live weight of 37 g were depleted for 14 days with a Zn-deficient diet of 1.3 mg Zn/kg. Thereafter, they were divided into 16 groups of 7 animals each. For another 14 days, two groups each were given diets containing 1.3, 4, 6, 8, 10, 12, 20 and 100ppm Zn. Then one of each of these groups were sacrificed, while the other received a Zn injection of 0.8 mg Zn/animal. Three days later, these 8 groups were also sacrificed in order to test the effect of Zn injection on several parameters of Zn supply.1. The Zn requirement for an optimum growth of the young rats was reached at 12 ppm. 2. The serum and bone contents increased in response to Zn injection up to the dietary supply of 20 ppm Zn; the Zn content of the testes was not affected. 3. The activity of the alkaline phosphatase in serum showed a significant increase after Zn injection up to those animals given 20 ppm dietary zinc and remained unchanged at 100ppm. 4. In bone and testes the activity of the alkaline phosphatase increased after Zn injection up to the groups with 8 and 10 ppm dietary Zn, respectively.The activity of the alkaline phosphatase in serum and its response to Zn injection thus represents a simple and sensitive system to assess the Zn supply status, especially the marginal supply. If an increase in the activity of the serum alkaline phosphatase can be obtained by Zn injection, a more or less pronounced Zn undernutrition, depending upon the observed activity increase, is indicated because no increase in the activity could be effected by additional Zn doses when the Zn status was optimal. 1. Der Zn-Bedarf ffir ein optimales Wachstum der jungen Ratten war bei 12 ppm erreicht. 2. Serum-und Knochen-Zn-Gehalte erh6hten sich nach einer Zn-Injektion bis zu einem Di~it-Zn-Gehalt von 20ppm und blieben im Hoden bei allen Gruppen unbeeinflugt. 3. Die Aktivitfit der alkalischen Phosphatase im Serum zeigte auf die ZnInjektion eine signifikante Aktivit~itserh6hung bis zu den Tieren mit einem Di~it-Zn-Gehalt von 20ppm. Sie blieb bei 100ppm unver~indert. 4. Im Knochen und Hoden erh6hte sich die Aktivit~it der alkalischen Phosphatase nach einer Zn-Injektion bis zu den Gruppen mit 8 bzw. 10 ppm DifitZn-Gehalt.Die Aktivit~it der alkalischen Phosphatase im Serum und deren Respons infolge einer Zn-Injektion stellt damit ein einfaches und sensitives System zur Bestimmung des Zn-Versorgungsstatus, speziell im marginalen Bereich, dar. Lfigt sich aufgrund einer Zn-Injektion eine Aktivit~itserh6hung der alkalischen Phosphatase im Serum erzielen, so mug je nach der H6he der festgestellten Aktivitfitserh6hung eine mehr oder weniger ausgeprfigte Zn-Unterversorgung vorgelegen haben, da bei einer optimalen Versorgung sich durch zusfitzliche Zn-Gaben keine Aktivit~ttserh6hung erzielen lieg.Schliisselwiirter: Zn-Mangel -Diagnose von Zn-Mangel -alkalische Phosphatase -saure Phosphatase -Zn-Injektion -Serum-Zn -Femur-ZnHoden-Zn

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Plasma Zinc and Copper in Diabetes Mellitus

Cited by 40 publications

References 0 publications

Plasma Mineral Content in Type-2 Diabetic Patients and Their Association with the Metabolic Syndrome

Plasma Mineral Content in Type-2 Diabetic Patients and Their Association with the Metabolic Syndrome

Associations of Dietary and Serum Copper with Inflammation, Oxidative Stress, and Metabolic Variables in Adults ,

Experimentelle Untersuchungen zur Diagnose von marginalem Zinkmangel

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