Plasma volume changes during and after acute variations of body hydration level in humans

Jimenez, Chantal; Melin, B.; Koulmann, Nathalie; Allevard, A. M.; Launay, Jean-Claude; Savourey, Gustave

doi:10.1007/s004210050550

Cited by 55 publications

(41 citation statements)

References 32 publications

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“…The dierences between the two dehydration procedures with respect to the responses of factors involved in renal sodium reabsorption, could have induced a better extracellular electrolyte retention during trial E. This could explain, at least in part, the maintained PV that was observed in that trial, as discussed extensively by Jimenez et al (1999) in a companion paper. The paper by Jimenez et al (1999) focussed on the vascular eects induced by thermal stress and exercise.…”

Section: Discussionmentioning

confidence: 78%

“…The paper by Jimenez et al (1999) focussed on the vascular eects induced by thermal stress and exercise.…”

Section: Discussionmentioning

confidence: 99%

“…The ®rst 30-min period was necessary to stabilise haemodynamic conditions, as recommended by Harrison (1985), before making the ®rst measure of PV during the next 60-min period by Evans blue dilution (Jimenez et al 1999).…”

Section: Experimental Protocolmentioning

confidence: 99%

“…The ®rst 30-min period was also necessary to stabilize haemodynamic conditions, and then a second measure of PV was made during the next 60-min period after another injection of Evans blue (Jimenez et al 1999).…”

Section: Experimental Protocolmentioning

confidence: 99%

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Comparison of passive heat or exercise-induced dehydration on renal water and electrolyte excretion: the hormonal involvement

Melin

Koulmann

Jimenez

et al. 2001

European Journal of Applied Physiology

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The effects of hydromineral hormones and catecholamines on renal water and electrolyte excretion were examined during and after dehydration induced by either passive heat or exercise. Eight healthy young Caucasian subjects participated in three separate trials, each including three consecutive phases. Phases 1 and 3 involved a 90-min period at rest in a thermoneutral environment, while phase 2 involved a 120-min period designed to provide: (1) euhydration (control trial), (2) passive heat-induced dehydration of 2.8% body mass, or (3) exercise-induced dehydration of 2.8% body mass. During the two dehydration procedures, the decreases in urine flow and sodium excretion were more marked during exercise (P < 0.05). An increase in plasma catecholamines occurred only during exercise, together with a reduction in creatinine clearance and more marked increases in plasma renin and aldosterone than during passive heat exposure (P < 0.05). Although plasma vasopressin was elevated during the two dehydration procedures, urine osmolality did not change and, moreover, free water clearance increased during exercise (P < 0.05). Plasma levels of atrial natriuretic peptide increased markedly only during exercise compared to the other trials (P < 0.05). After the dehydration procedures, urine flow decreased again and urine osmolality increased markedly (P < 0.05), while plasma vasopressin remained elevated. These results suggest that sympathoadrenal activation during exercise plays a major role in the more marked reduction in diuresis and natriuresis than during passive heat exposure. Despite high plasma vasopressin concentrations during the two dehydrating events, the observed antidiuresis was not due to an increased renal concentrating ability, and the vasopressin was more effective after the dehydration procedures.

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Section: Discussionmentioning

confidence: 78%

“…The paper by Jimenez et al (1999) focussed on the vascular eects induced by thermal stress and exercise.…”

Section: Discussionmentioning

confidence: 99%

Section: Experimental Protocolmentioning

confidence: 99%

Section: Experimental Protocolmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of passive heat or exercise-induced dehydration on renal water and electrolyte excretion: the hormonal involvement

Melin

Koulmann

Jimenez

et al. 2001

European Journal of Applied Physiology

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“…Following glycerol consumption, the heart rate and body core temperature are lower during exercise in the heat, suggesting an ergogenic effect. In endurance type of activities, a larger supply of stored water may lead to a delay in dehydration and exhaustion [32,33]. More specifically, one study examined the effect of glycerol (1 g/kg) supplementation on body temperature while exercising on a treadmill (60 % VO 2 max) at 42°C at 25 % relative humidity for 90 min 2.5 h after ingestion of the glycerol.…”

Section: Glycerolmentioning

confidence: 99%

Fluid Balance and Hydration for Human Performance

Johannsen

Earnest

2015

Nutritional Supplements in Sports and Exercise

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This chapter examines fluid balance for human performance. Topics reviewed in this chapter include the nature and function of water in human physiology as it pertains to maintaining daily fluid balance; the relationship of fluid balance to human performance when administered before, during, and after exercise; and the efficacy of carbohydrate and specially formulated drinks to promote improved fluid balance. While dehydration is rarely observed during lower-intensity exercise associated with physical activity while indoors and under controlled environmental conditions, increased preventive strategies are required at higher-intensity, longer exercise bouts and under more extreme conditions. The chapter concludes with recommendations to optimize fluid balance in recreational activities and sports. Keywords Hydration • Fluid balance • Water • Exercise Nature of Water in the Human BodyWater is considered the most essential macronutrient, as death can occur in as few as 3-7 days in the absence of adequate fluid intake. Water accounts for approximately 60 % of total body weight although the actual percentage varies greatly depending on several factors including age, sex, health status, and body composition. Specifically, body water percent is higher in individuals with a greater lean muscle mass (~65-75 %) and, consequently, lower in obese

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A step towards removing plasma volume variance from the Athlete's Biological Passport: The use of biomarkers to describe vascular volumes from a simple blood test

Lobigs

Sottas²,

Bourdon

et al. 2017

Drug Testing and Analysis

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The haematological module of the Athlete's Biological Passport (ABP) has significantly impacted the prevalence of blood manipulations in elite sports. However, the ABP relies on a number of concentration-based markers of erythropoiesis, such as haemoglobin concentration ([Hb]), which are influenced by shifts in plasma volume (PV). Fluctuations in PV contribute to the majority of biological variance associated with volumetric ABP markers. Our laboratory recently identified a panel of common chemistry markers (from a simple blood test) capable of describing ca 67% of PV variance, presenting an applicable method to account for volume shifts within anti-doping practices. Here, this novel PV marker was included into the ABP adaptive model. Over a six-month period (one test per month), 33 healthy, active males provided blood samples and performed the CO-rebreathing method to record PV (control). In the final month participants performed a single maximal exercise effort to promote a PV shift (mean PV decrease -17%, 95% CI -9.75 to -18.13%). Applying the ABP adaptive model, individualized reference limits for [Hb] and the OFF-score were created, with and without the PV correction. With the PV correction, an average of 66% of [Hb] within-subject variance is explained, narrowing the predicted reference limits, and reducing the number of atypical ABP findings post-exercise. Despite an increase in sensitivity there was no observed loss of specificity with the addition of the PV correction. The novel PV marker presented here has the potential to improve the ABP's rate of correct doping detection by removing the confounding effects of PV variance.

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Plasma volume changes during and after acute variations of body hydration level in humans

Cited by 55 publications

References 32 publications

Comparison of passive heat or exercise-induced dehydration on renal water and electrolyte excretion: the hormonal involvement

Comparison of passive heat or exercise-induced dehydration on renal water and electrolyte excretion: the hormonal involvement

Fluid Balance and Hydration for Human Performance

A step towards removing plasma volume variance from the Athlete's Biological Passport: The use of biomarkers to describe vascular volumes from a simple blood test

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