Plasma vitamin E and beta-carotene concentrations during radiochemotherapy preceding bone marrow transplantation

Clemens, Michael; Ladner, Claudia; Ehninger, Gerhard; Einsele, Hermann; Renn, W.; Bühler, Ernst; Waller, H. D.; Gey, K. F.

doi:10.1093/ajcn/51.2.216

Cited by 66 publications

(26 citation statements)

References 7 publications

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“…Plasma MDA levels were found to be increased after high-dose therapy in these patients (1, 3, 7). In erythrocytes, SOD, glutathione peroxidase and CAT activities were reported to be decreased or increased (1,3,4,7,9). Furthermore, plasma antioxidants such as atocopherol, b-carotene and vitamin C were shown to be depleted (3,(8)(9)(10).…”

Section: Discussionmentioning

confidence: 99%

“…They have severe acute and delayed toxic effects on several tissues, such as mucous membranes, gastrointestinal tract, liver, lung, bladder, central nervous system, and, rarely, other tissues possibly related to peroxidation processes and exhaustion of antioxidants. [3][4][5][6][7] It is well known that chemotherapy and radiation therapy are associated with the formation of reactive oxygen species and depletion of antioxidants, such as glutathione (GSH), antioxidant enzymes, and antioxidant vitamins such as a-tocopherol, b-carotene and vitamin C. 4,[8][9][10][11] A limited number of studies demonstrated that the conditioning therapy given to HSCT patients creates a high oxidative stress, resulting in a measured reduction in antioxidants. In summary, these studies revealed a disturbance of the pro-oxidative/antioxidative balance in the plasma of patients undergoing HSCT.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it has been suggested that high-dose chemotherapy increased the oxidative stress and decreased the antioxidant defence system. [3][4][5][6][7][8][9][10][11] The objective of this study was to evaluate the oxidative and antioxidative status in pediatric allo-HSCT patients.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of oxidative and antioxidative parameters in pediatric hematopoietic SCT patients

Sabuncuoğlu

Kuşkonmaz

Çetinkaya

et al. 2011

Bone Marrow Transplant

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Conditioning regimens preceding hematopoietic SCT (HSCT) usually consist of high-dose chemotherapy. Chemotherapy and radiation therapy are associated with increased formation of free radicals and depletion of critical plasma and tissue antioxidants. Oxidative stress and antioxidant depletion have been described during the transplantation period in HSCT patients. In a limited number of studies, it was observed that the conditioning regimen resulted in oxidative stress and antioxidant depletion in HSCT patients. The objective of this study was to look for further evidence of oxidative stress and antioxidant status in pediatric HSCT patients. In this study, blood samples were collected from 21 pediatric allo-HSCT patients before and after conditioning therapy. Erythrocyte and plasma malondialdehyde (MDA) levels, erythrocyte reduced and oxidized glutathione (GSH) levels, erythrocyte antioxidant enzymes activities, plasma a-tocopherol and b-carotene levels were determined. After high-dose chemotherapy, erythrocyte and plasma MDA levels increased. Reduced GSH levels decreased whereas oxidized GSH levels increased first and then decreased significantly compared with the values before the chemotherapy regimen. It was also observed that catalase, superoxide dismutase and GSH-S-transferase activities decreased, but there was no change in GSH peroxidase activity. On the other hand, plasma a-tocopherol levels increased, but b-carotene levels did not change.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of oxidative and antioxidative parameters in pediatric hematopoietic SCT patients

Sabuncuoğlu

Kuşkonmaz

Çetinkaya

et al. 2011

Bone Marrow Transplant

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“…The insufficient supply of antioxidant micronutrients of many cancer patients can also be seen in the fact that their oxidative stress markers are often increased (120,(134)(135)(136). The problem is aggravated by the falling vitamins A (137) and E (137,(138)(139)(140) blood levels under radiation therapy.…”

Section: Tumor-associated Deficit Of Micronutrients -Pathophysiologicmentioning

confidence: 99%

Nutrition in oncology: the case of micronutrients (Review)

Ströhle¹

2010

Oncol Rep

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Abstract. In the course of cancer disease, many oncological patients develop tumor-associated malnutrition characterized by an insufficient supply of macro-and micronutrients. The inadequate nutritional status and the cancer anorexia-cachexia syndrome related to it are clinically relevant, as the response to antineoplastic measures, such as radiation and chemotherapy, is diminished, their side effects aggravated and the patient's quality of life and prognosis negatively affected. Therefore, the supportive nutrition care of oncological patients is of central importance. In this context, vitamins, minerals and long-chain ˆ-3 fatty acids are becoming more and more relevant in oncology although the benefit of such supplements is discussed controversially. Starting from a description of the etiopathogenesis and the pathophysiological consequences of cancer-associated malnutrition, the present study provides an overview of the importance of micronutrients for oncological patients. In the case of reduced food intake and/or inappropriate food choice the use of a multi-vitaminmultimineral supplement administered in physiological doses, i.e. nutrient quantities approximately corresponding to the recommended daily allowances, can be generally recommended. However, to enhance postoperative wound healing, it seems that cancer patients require higher amounts of micronutrients than healthy individuals. Because vitamin D deficiency is highly prevalent in oncological patients, improvement of vitamin D status is of special interest.

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“…b-Carotene levels fell by 50% and vitamin E (a-tocopherol) levels by 20%. 72,73 It has long been known that both chemotherapy and radiotherapy cause malnutrition and vitamin deficiencies. 74 It seems entirely unnecessary that in the 21st century, cancer patients should still be suffering from such deprivation.…”

Section: Correcting Malnutritionmentioning

confidence: 99%

Should Patients Undergoing Chemotherapy and Radiotherapy Be Prescribed Antioxidants?

Moss¹

2006

Integr Cancer Ther

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In September 2005, CA: A Cancer Journal for Clinicians published a warning by Gabriella D'Andrea, MD, against the concurrent use of antioxidants with radiotherapy and chemotherapy. However, several deficiencies of the CA article soon became apparent, not least the selective omission of prominent studies that contradicted the author's conclusions. While acknowledging that only large-scale, randomized trials could provide a valid basis for therapeutic recommendations, the author sometimes relied on laboratory rather than clinical data to support her claim that harm resulted from the concurrent use of antioxidants and chemotherapy. She also sometimes extrapolated from chemoprevention studies rather than those on the concurrent use of antioxidants per se. The article overstated the degree to which the laboratory data diverged in regard to the safety and efficacy of antioxidant therapy: in fact, the preponderance of data suggests a synergistic or at least harmless effect with most high-dose dietary antioxidants and chemotherapy. The practical recommendations made in the article to avoid the general class of antioxidants during chemotherapy are inconsistent, in that if antioxidants were truly a threat to the efficacy of standard therapy, antioxidant-rich foods, especially fruits and vegetables, ought also be proscribed during treatment. Yet no such recommendation is made. Furthermore, the wide-scale use by both medical and radiation oncologists of synthetic antioxidants (eg, amifostine) to control the adverse effects of cytotoxic treatments is similarly overlooked. In sum, this CA article is incomplete: there is far more information available regarding antioxidant supplements as an appropriate adjunctive cancer therapy than is acknowledged. Patients would be well advised to seek the opinion of physicians who are adequately trained and experienced in the intersection of 2 complex fields, that is, chemotherapeutics and nutritional oncology. Physicians whose goal is comprehensive cancer therapy should refer their patients to qualified integrative practitioners who have such training and expertise to guide patients. A blanket rejection of the concurrent use of antioxidants with chemotherapy is not justified by the preponderance of evidence at this time and serves neither the scientific community nor cancer patients.

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Plasma vitamin E and beta-carotene concentrations during radiochemotherapy preceding bone marrow transplantation

Cited by 66 publications

References 7 publications

Evaluation of oxidative and antioxidative parameters in pediatric hematopoietic SCT patients

Evaluation of oxidative and antioxidative parameters in pediatric hematopoietic SCT patients

Nutrition in oncology: the case of micronutrients (Review)

Should Patients Undergoing Chemotherapy and Radiotherapy Be Prescribed Antioxidants?

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