Plasma Vitamin C and Cancer Death: The Prospective Basel Study

Stähelin, H B; Gey, K. F.; Brubacher, G.

doi:10.1111/j.1749-6632.1987.tb23756.x

Cited by 24 publications

(10 citation statements)

References 9 publications

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“…An inverse relationship between plasma levels of essential antioxidants and incidence of cardiovascular diseases [14,15] or cancer [16][17][18] has been described. Gey [ 19] reported 336 Krajcoviiovà-Kudlàckovà/Simoncic/ Vitamins and Trace Elements in Babinskâ/Bédcrovâ/Brtkovà/Magàlovâ/ Vegetarians GranCiCovà threshold values relating to the risk of these diseases for vitamin C (40-50 j.tmol/1).…”

Section: Discussionmentioning

confidence: 99%

Selected Vitamins and Trace Elements in Blood of Vegetarians

Krajcovicová-Kudlácková

Simoncic

Babinská

et al. 1995

Ann Nutr Metab

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Selected vitamin (A, C, E, β-carotene) and trace element (selenium, zinc, copper) levels were estimated in the blood of 67 vegetarian nonsmokers aged 34-60 years. The average period of lacto- or lacto-ovovegetarianism was 6.2 years. The results were compared with those of 75 nonvegetarians of the same age and living in the same region. Vegetarians had significantly higher plasma levels of essential antioxidants: vitamin C, β-carotene, and vitamin A. A significantly higher molar ratio vitamin E/cholesterol indicates a more effective protection especially of low-density lipoproteins against peroxidation. Oxidation of low-density lipoproteins represents one of the key factors in the pathogenesis of atherosclerosis. The molar ratio vitamin E/total lipids was significantly higher in plasma of vegetarians, demonstrating a more effective protection of polyunsaturated fatty acids against peroxidation. Vegetarians had significantly higher plasma levels of selenium and similar levels of zinc and copper when compared to nonvegetarians. These trace elements are important for the activity of antioxidant enzymes. The results document a beneficial effect of vegetarian nutritional habits on antioxidative parameters and thus on the reduction of cardiovascular diseases and cancer risk. Reactive products of oxygen metabolism and subsequent toxic products of lipid peroxidation play an important role in the etiology of these diseases.

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Section: Discussionmentioning

confidence: 99%

Selected Vitamins and Trace Elements in Blood of Vegetarians

Krajcovicová-Kudlácková

Simoncic

Babinská

et al. 1995

Ann Nutr Metab

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“…In a previously reported nutri tional survey, we observed a decreased dietary intake of AA by women having cervical dysplasias [9]. In a subse quent study, we determined the plasma AA levels of women with cervical carcinoma in situ and cancer to be significantly lower compared to controls [1], Signifi cantly lower plasma AA concentrations have been re ported in patients with cancer and ascribed to a prefer ential accumulation of the micronutrient by malignant tissues [10,11], GSH is a ubiquitous molecule that par ticipates in cell division and in hormone-receptor inter actions [12]. In malignant states, the GSH concentration in both erythrocytes and cancer tissues is markedly ele vated [13][14][15].…”

Section: Discussionmentioning

confidence: 91%

“…The cell pellet was homogenized with a solution containing 1.67 g% glacial metaphosphoric acid; 0.2 g% EDTA; and 30 g% NaCl. The homogenate after 10 min in ice was centrifuged at 800 g for another 10 min. An aliquot of the super natant was mixed with 0.3 M NaiHPCL solution.…”

Section: Biochemical Determinationsmentioning

confidence: 99%

Measurements of Ascorbic Acid and Glutathione in Exfoliated Cervicovaginal Epithelial Cells of Smokers and Women with Cervical Dysplasias

Basu¹,

Mikhail²,

Goldberg³

et al. 1990

Gynecol Obstet Invest

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This report emphasizes the ability to quantify ascorbic acid (AA) and reduced glutathione (GSH) levels in exfoliated cervicovaginal epithelial cells obtained by a lavage technique. Sixty-two women with abnormal Papanicolaou smears underwent colposcopic examinations. Colposcopic lesions were biopsied and histopathologically graded. Marked variations in the number of cells and in the levels of AA and GSH were observed. In cigarette smokers, the number of exfoliated cells retrieved was significantly higher (p < 0.05, by Student’s t test). The simultaneous investigation of biochemical and virologic parameters in exfoliated cervicovaginal epithelial cells, in conjunction with the known cytopathologic and epidemiologic risk variables, provides a novel approach to elucidate factor(s) that may inhibit or promote cervical carcinogenesis in designed prospective studies.

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“…Interlaboratory epidemiologic studies are used by the National Cancer Institute and others as one of the mechanisms for investigating the potential of AA as a cancer chemopreventative agent (1)(2)(3)(4)(5). For these studies to yield the most meaningful results, plasma and (or) serum AA concentrations determined at different times or in different laboratories must be comparable.…”

confidence: 99%

“…Ascorbic acid (AA) 3 has been proposed as having cancer chemopreventive activity (1 ). Interlaboratory epidemiologic studies are used by the National Cancer Institute and others as one of the mechanisms for investigating the potential of AA as a cancer chemopreventative agent (1)(2)(3)(4)(5).…”

confidence: 99%