Plasma vitamin A and retinol-binding protein in premature and term neonates

Shenai, Jayant P.; Chytil, Frank; Jhaveri, Asha; Stahlman, Mildred T.

doi:10.1016/s0022-3476(81)80484-2

Cited by 165 publications

(63 citation statements)

References 7 publications

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“…19,20 Many other researchers have also inferred that plasma retinal may reflect the availability of its carrier protein, RBP, which is deficient in preterms. 21,22 We did not find any correlation between birth weight and plasma vitamin A levels in term normal birth weight babies. However, there was a significant correlation (P < 0.001) between birth weight and vitamin A levels in the whole group (n = 154) of LBW babies.…”

Section: Discussioncontrasting

confidence: 62%

Umbilical cord blood plasma vitamin A levels in low birth weight (LBW) babies

Adhikari¹,

Somani

Kalra³

et al. 2011

Medical Journal Armed Forces India

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Section: Discussioncontrasting

confidence: 62%

Umbilical cord blood plasma vitamin A levels in low birth weight (LBW) babies

Adhikari¹,

Somani

Kalra³

et al. 2011

Medical Journal Armed Forces India

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“…Vitamin A deficiency occurs often in ELBW infants 1 and may predispose to BPD. 2 Multiple randomized controlled trials and a systematic review have shown that vitamin A supplementation decreases BPD or death.…”

Section: Introductionmentioning

confidence: 99%

Retinol-Binding Protein, Transthyretin, and C-Reactive Protein in Extremely Low Birth Weight (ELBW) Infants

2005

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BACKGROUND:Vitamin A deficiency reduces retinol binding protein (RBP) but not transthyretin (TTR), while inflammation reduces both RBP and TTR and increases C-reactive protein (CRP), an acute phase reactant. OBJECTIVE:To estimate serum RBP, TTR, and CRP in ELBW infants to test the hypotheses that (a) TTR is a negative acute phase reactant and (b) a higher RBP/TTR ratio or CRP is associated with death/BPD by 36 weeks corrected age. DESIGN/METHODS:Serum RBP, TTR, and CRP were measured in 79 ELBW infants at 28 days. Area under the curve (AUC) of receiver operating characteristic curve analysis evaluated the predictive value of TTR, the RBP/TTR ratio, and CRP for death/BPD at 36 weeks. RESULTS:(1) TTR inversely correlated with CRP (r ¼ À0.45, p<0.0001) consistent with TTR being a negative acute phase reactant. (2) The RBP/TTR ratio predicted death/BPD (AUC 0.68 (CI 0.57 to 0.78)). (3) CRP strongly predicted death/BPD (AUC 0.85 (CI 0.76 to 0.92)), even after exclusion of sepsis. CONCLUSIONS:A higher CRP and RBP/TTR molar ratio on day 28 are associated with death/BPD at 36 weeks in ELBW infants. Lower TTR and maintained RBP/TTR ratios suggest inflammation rather than vitamin A deficiency as the cause for lower serum vitamin A levels in ELBW infants.

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“…Previous studies have Vitamin A and E status in preterm infant S Kositamongkol et al consistently shown high incidence of fat-soluble vitamin deficiency, especially vitamin A in VLBW infants. 15 In breast-fed preterm and term infants, Henriksen et al 7 reported that plasma retinol concentrations in preterm infants at discharge were significantly lower than term counterparts at 4 weeks of age. However, there was no significant difference in plasma a-tocopherol between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Vitamin A and E status in very low birth weight infants

et al. 2011

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Objective: To determine vitamin A and vitamin E status in very low birth weight (VLBW) infants at the time of birth (TB), at the time of full feeding (TFF) and at term postmenstrual age (TT).Study Design: An observational study was conducted in VLBW infants. Plasma retinol and a-tocopherol levels were measured at TB, TFF and TT. Multivitamin supplementation was given to all infants to meet the daily requirement.Result: A total of 35 infants were enrolled. The median (interquartile range) of gestational age and birth weight was 30 (28 to 32) weeks and 1157 g (982 to 1406 g). The median of vitamin A and vitamin E intakes from TFF to TT was 832 and 5.5 IU kg -1 day -1 , respectively. Vitamin A deficiency occurred in 67.7% at birth, 51.6% at TFF and 82.1% at TT. Vitamin E deficiency occurred in 77.4% at birth, 16.1% at TFF and 35.7% at TT. Small-for-gestational age was the only risk factor for vitamin A deficiency. Lower amount of breast milk consumption was associated with higher incidence of vitamin E deficiency. No differences in vitamin A-or vitamin E-related morbidities between infants with and without vitamin deficiencies were found.Conclusion: High prevalence of vitamin A and vitamin E deficiency was found in VLBW infants starting from birth to term postmenstrual age. Therefore, a higher dose of vitamin supplementation is required.

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Plasma vitamin A and retinol-binding protein in premature and term neonates

Cited by 165 publications

References 7 publications

Umbilical cord blood plasma vitamin A levels in low birth weight (LBW) babies

Umbilical cord blood plasma vitamin A levels in low birth weight (LBW) babies

Retinol-Binding Protein, Transthyretin, and C-Reactive Protein in Extremely Low Birth Weight (ELBW) Infants

Vitamin A and E status in very low birth weight infants

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