Plasma visfatin levels in normal weight women with polycystic ovary syndrome

Panidis, Dimitrios; Farmakiotis, Dimitrios; Rousso, David; Katsikis, Ilias; Delkos, Dimitrios; Piouka, Athanasia; Gerou, Spiros; Diamanti-Kandarakis, Evanthia

doi:10.1016/j.ejim.2007.05.014

Cited by 56 publications

(77 citation statements)

References 38 publications

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“…It has previously been reported that the gene expression and circulating levels of visfatin were increased in women with PCOS compared with age-and BMImatched controls (Tan et al 2006a, Chan et al 2007, Kowalska et al 2007, Panidis et al 2008, Carmina et al 2009, Ozkaya et al 2010, Plati et al 2010, Seow et al 2011, as shown in Table 1. However, several recently published studies did not find a difference in plasma or serum visfatin levels between patients with PCOS and control groups (Guducu et al 2012, Lajunen et al 2012, Olszanecka-Glinianowicz et al 2012.…”

Section: Visfatinmentioning

confidence: 86%

“…Although there are conflicting data on the relationship between visfatin and obesity (Haider et al 2006, Pagano 2006, Choi et al 2007, Filippatos et al 2007, Panidis et al 2008, Chang et al 2010), a recent metaanalysis revealed that plasma visfatin is significantly increased in subjects diagnosed with overweight/obesity, T2DM, metabolic syndrome, and CVD (Chang et al 2011). Circulating visfatin levels were also found to be positively associated with IR (Chang et al 2011).…”

Section: Visfatinmentioning

confidence: 99%

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Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Chen¹,

Jia²,

Qiao³

et al. 2013

Journal of Molecular Endocrinology

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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

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Section: Visfatinmentioning

confidence: 86%

Section: Visfatinmentioning

confidence: 99%

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Chen¹,

Jia²,

Qiao³

et al. 2013

Journal of Molecular Endocrinology

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show abstract

“…In addition to obesity and a positive family history of type 2 diabetes, other risk factors are being discussed to contribute to the high prevalence of insulin resistance and abnormal glucose metabolism in PCOS women. Low adiponectin, high leptin (25), and low ghrelin (26) levels were shown to be associated with insulin resistance and BMI in PCOS patients. RBP4 levels were associated with obesity, insulin resistance, and type 2 diabetes not only in mouse models of obesity and insulin resistance, but also in humans with these conditions.…”

Section: Discussionmentioning

confidence: 99%

Retinol-binding protein 4 levels are elevated in polycystic ovary syndrome women with obesity and impaired glucose metabolism

et al. 2007

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Objective: Insulin resistance and obesity are common features of the polycystic ovary syndrome (PCOS). Retinol-binding protein 4 (RBP4), a new fat-derived adipokine, has been described to be elevated in obesity and type 2 diabetes. The aim of the present study was to investigate whether serum RBP4 levels are correlated with metabolic parameters, indices of insulin resistance, and endocrine variables in German PCOS women. Design: We assessed the correlation between metabolic and endocrine parameters with RBP4 levels in 200 PCOS patients and 64 healthy controls. Methods: Serum RBP4 was measured by enzyme-linked immunosorbent assay (Immundiagnostik AG, Bensheim, Germany). In addition, anthropometric variables, clinical signs of hyperandrogenism, and body fat were evaluated, and a glucose tolerance test was performed to assess parameters of insulin resistance and glucose metabolism. Results: Taking the entire PCOS cohort, RBP4 levels were positively correlated with body mass index (BMI), body fat, waist circumference, fasting glucose, and area under the curve for glucose (all P!0.05), but not with indices of insulin resistance. On the other hand, PCOS women with impaired glucose metabolism had higher RBP4 levels than PCOS women with normal glucose metabolism (median 30.6, range 23.3-73.9 versus median 26.3, range 6.4-61.4, P!0.05). Furthermore, no differences were found in RBP4 levels between lean PCOS women and BMI-matched healthy controls. Conclusion: In German PCOS women, serum RBP4 levels are associated with obesity and parameters of glucose metabolism but not with PCOS per se.

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“…Numerous studies have focused on the impact of obesity on the hyperandrogenic state in women with PCOS and a possible link with leptin (Panidis et al 2003). To our knowledge, there are no data concerning leptin and cyst formation in pig.…”

Section: Discussionmentioning

confidence: 99%

Supraphysiological leptin levels shift the profile of steroidogenesis in porcine ovarian follicles toward progesterone and testosterone secretion through increased expressions of CYP11A1 and 17β-HSD: a tissue culture approach

Gregoraszczuk¹,

Rak²

2013

Reproduction

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Evidence from both clinical and animal studies suggests that exposure to excess androgens results in cyst formation. The present in vitro study assessed the effects of supraphysiological concentrations of leptin (20 and 40 ng/ml) on progesterone (P4), androstenedione androstendione (A4), testosterone and estradiol (E2) secretion by ELISA and the expression of CYP11A1, CYP17, 17β-hydroxysteroid dehydrogenase (17β-HSD) and CYP19 by western blot to answer the question of whether leptin could be independent risk factor for cyst formation in pigs. Small- and medium-sized ovarian follicles were collected from prepubertal and cycling pigs. Increased P4 and testosterone secretions were observed in both small- and medium-sized follicles in prepubertal and cycling animals whereas there was no change in E2 secretion. Leptin treatment resulted in an increase in CYP11A1 and 17β-HSD protein expression but had no effect on CYP17 and CYP19 expression in follicles of either size from prepubertal and cycling pigs. Results of presented data suggest that leptin in elevated doses, by stimulatory effect on CYP11A1 and 17β-HSD protein expression resulting in elevated P4 and testosterone secretions could be an independent risk factor for cyst formation in both prepubertal and cycling pigs.

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Plasma visfatin levels in normal weight women with polycystic ovary syndrome

Cited by 56 publications

References 38 publications

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Retinol-binding protein 4 levels are elevated in polycystic ovary syndrome women with obesity and impaired glucose metabolism

Supraphysiological leptin levels shift the profile of steroidogenesis in porcine ovarian follicles toward progesterone and testosterone secretion through increased expressions of CYP11A1 and 17β-HSD: a tissue culture approach

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