Plasma visfatin is reduced after aerobic exercise in early onset type 2 diabetes mellitus

Brema, Imad; Hatunic, Mensud; Finucane, Francis; Burns, Nicole; Nolan, John J.; Haider, Dominik G.; Wolzt, Michael; Ludvik, Bernhard

doi:10.1111/j.1463-1326.2008.00872.x

Cited by 41 publications

(29 citation statements)

References 10 publications

(16 reference statements)

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“…Previous studies (25,26) showed a reduction in plasma visfatin after aerobic exercise training in patients with type 2 diabetes and type 1 diabetes compared with matched controls. In addition, exercise training that resulted in weight loss induced significant reductions in plasma visfatin in young, overweight Korean women (27).…”

Section: Discussionmentioning

confidence: 99%

Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats

Gao

Wang

Pan

et al. 2014

Arq Bras Endocrinol Metab

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Objective: Visfatin is a recently discovered adipocytokine that contributes to glucose and obesityrelated conditions. Until now, its responses to the insulin-sensitizing agent metformin and to exercise are largely unknown. We aim to investigate the impact of metformin treatment and/or swimming exercise on serum visfatin and visfatin levels in subcutaneous adipose tissue (SAT), peri-renal adipose tissue (PAT) and skeletal muscle (SM) of high-fat-induced obesity rats. Materials and methods:Sprague-Dawley rats were fed a normal diet or a high-fat diet for 16 weeks to develop obesity model. The high-fat-induced obesity model rats were then randomized to metformin (MET), swimming exercise (SWI), or adjunctive therapy of metformin and swimming exercise (MAS), besides high-fat obesity control group and a normal control group, all with 10 rats per group. Zoometric and glycemic parameters, lipid profile, and serum visfatin levels were assessed at baseline and after 6 weeks of therapy. Visfatin levels in SAT, PAT and SM were determined by Western Blot. Results: Metformin and swimming exercise improved lipid profile, and increased insulin sensitivity and body weight reduction were observed. Both metformin and swimming exercise down-regulated visfatin levels in SAT and PAT, while the adjunctive therapy conferred greater benefits, but no changes of visfatin levels were observed in SM. Conclusion: Our results indicate that visfatin down-regulation in SAT and PAT may be one of the mechanisms by which metformin and swimming exercise inhibit obesity.Arq Bras Endocrinol Metab. 2014;58(1):42-7 Keywords Endocrinology; metabolic syndrome; adipocytokine RESUMO Objetivo: A visfatina é uma adipocina recentemente descoberta que contribui com as condições relacionadas à glicose e à obesidade. Até hoje, pouco se sabe da sua resposta à metformina, um agente sensibilizador de insulina, e ao exercício. Nosso objetivo foi investigar o impacto do tratamento com metformina e/ou da natação sobre a visfatina no soro e no tecido adiposo subcutâneo (TAS), tecido adiposo perirrenal (TAP) e músculo esquelético (ME) em ratos com obesidade induzida por dieta com alto teor de gordura. Materiais e métodos: Ratos Sprague-Dawley foram alimentados com uma dieta normal ou com alto teor de gordura por 16 semanas para o desenvolvimento de um modelo de obesidade. Os ratos do modelo de obesidade foram, então, randomizados para a metformina, natação ou terapia de combinação com metformina e natação, além do grupo controle de obesidade induzida por alto teor de gordura e do grupo controle normal. Cada grupo apresentava 10 ratos. Parâmetros zoométricos e glicêmicos, perfil lipídico e níveis de visfatina sérica foram avaliados no momento inicial e após seis semanas de tratamento. Os níveis de visfatina em TAS, TAP e ME foram determinados por Western Blot. Resultados: A metformina e a natação melhoraram o perfil lipídico e aumentaram a sensibilidade à insulina, com redução do peso corporal. Tanto a metformina quanto a natação levaram à regulação para baixo do...

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Section: Discussionmentioning

confidence: 99%

Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats

Gao

Wang

Pan

et al. 2014

Arq Bras Endocrinol Metab

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“…According to our results from multiple regression analysis there was a significant positive correlation between visfatin and parameters of LDL and Cho, so reducing LDL and Cho levels in post-test status can affect visfatin reduction. One study from Brema et al also indicated correlation between PVL changes and changes in BF% and blood HDL level in diabetic patients [55,56].…”

Section: On Visfatinmentioning

confidence: 99%

Investigation of Plasma Visfatin Changes in Women with Type 2 Diabetes followed by Endurance, Resistance and Combined Exercise: The Role of Lipid Profile, Glycemic Indices and Insulin Resistance

Mehdizadeh¹,

Hamzezadeh²,

Tofighi³

2016

J Diabetes Metab

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Background and purpose: Visfatin is one of insulin-like proteins secreted by adipose tissue associated with obesity and insulin resistance, but the effect of exercise on the levels of this hormone is unclear, despite various studies in this area. The aim of this study was to compare the effects of aerobic, resistance and combined exercises (strength-aerobic) on visfatin changes, glycemic and lipid parameters and evaluation of relationship between visfatin and insulin resistance in women with Diabetes Mellitus Type 2 (DMT2). The recent study differs with other studies in terms of exercise type, sample size, type of subjects and results. Materials and Methods:Forty women with DMT2 were selected by purposive sampling method based on availability then randomly divided into four equal groups; three patient (training) groups including aerobic exercise group (20-50 min/day, with an intensity of 60 to 80% of maximum heart rate), resistance group (3 sets, 10 reps, with an intensity of 50 to 65% of one repetition maximum), combined group (with the same intensity and duration of exercises in aerobic and resistance groups) and no-training group as control group. All patient groups participated in 12-week training program for three sessions per week. Fasting blood samples were collected to evaluate of plasma visfatin levels, insulin, glycated hemoglobin, glucose, cholesterol (Cho), triglycerides, HDL and LDL. To calculate the insulin resistance index HOMA-IR equation was used. Data analysis was performed using two-way ANOVA, Kolmogorov-Smirnov test, Levene's test, multiple linear regressions and post hoc Tukey test.Results: Data analysis showed that the weight index was decreased in aerobic group compared with resistance group. Body fat percentage in combined group was significantly lower than aerobic group and also in aerobic group as compared with control and resistance groups. Waist-to-hip ratio was decreased in aerobic group than combined group. Markers of insulin and insulin resistance reduced in resistance group compared with aerobic and combined groups. LDL index were significantly lower in combined group compared with the resistance and also Cho in resistance group as compared with aerobic and combined groups. There were no significant differences between mean changes of Hb A1c and mean visfatin changes in 4 groups. Conclusions:Even though in the present study; no significant differences were observed in mean changes of Hb A1c and PVL among groups, but each type of exercises had a positive impact on certain parameters in experimental groups. Longitudinal studies with more participants are needed for evaluation of relationship between visfatin and insulin resistance in women with DMT2.

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“…42 We studied the relationship between circulating plasma visfatin and insulin resistance measured by euglycemic hyperinsulinemic clamp in subjects with early onset type 2 diabetes and severe insulin resistance in comparison with age and BMI-matched, insulin sensitive, obese controls and found no difference in plasma Visfatin concentration between the two groups. 43 Moreover, while we reported a significant reduction in plasma visfatin concentration following 12 weeks of an aerobic exercise intervention programme, insulin sensitivity and weight did not change in that study. 43 From the above studies, it seems that the association between Visfatin and insulin resistance is debatable.…”

Section: Visfatin and Insulin Resistancementioning

confidence: 91%

The Relationship between Plasma Visfatin/Nampt and Type 2 Diabetes, Obesity, Insulin Resistance, and Cardiovascular Disease

Brema¹

2016

EMIJ

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Plasma visfatin is reduced after aerobic exercise in early onset type 2 diabetes mellitus

Cited by 41 publications

References 10 publications

Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats

Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats

Investigation of Plasma Visfatin Changes in Women with Type 2 Diabetes followed by Endurance, Resistance and Combined Exercise: The Role of Lipid Profile, Glycemic Indices and Insulin Resistance

The Relationship between Plasma Visfatin/Nampt and Type 2 Diabetes, Obesity, Insulin Resistance, and Cardiovascular Disease

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