Plasma Uric Acid Level and Its Association With Diabetes Mellitus and Some Biologic Parameters in a Biracial Population of Fiji

Tuomilehto, Jaakko; Zimmet, Paul; Wolf, Eva; Taylor, Richard; Ram, Parshu; King, Hilary

doi:10.1093/oxfordjournals.aje.a114807

Cited by 148 publications

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“…These findings are higher than the study conducted by Tuomilehto J et al who found prevalence of 22% and 11% for males and females respectively. 21 In our study, the data indicates that serum triglyceride is markedly associated with hyperuricemia (p<0.05). Conen et al and Schachter et al showed the same results (p<0.05).…”

Section: Discussionsupporting

confidence: 54%

The study of prevalence of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus

Mundhe

Mhasde

2016

Int J Adv Med

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INTRODUCTIONType 2 diabetes mellitus (type 2 DM) is associated with cardiovascular complications, of which metabolic syndrome (Mets) plays a prominent role. The metabolic syndrome is a cluster of cardiovascular risk factors that is characterized by central obesity, insulin resistance, dyslipidemia and hypertension. 1 Hyperuricemia or elevated serum uric acid levels (SUA) is a biochemical entity that is gaining increasing importance as it is found by some researchers to be not only a cardiovascular risk factor but also plays a role in development of renal and metabolic diseases.2-4 Some reports on SUA and metabolic syndrome have noted that increased SUA concentration is associated with increased prevalence of some of the parameters of the metabolic syndrome like obesity, dyslipidemia and hypertension. 5,6 In these reports, the documented prevalence rates of hyperuricemia ranged from 13-19% with greater proportions of males having elevated levels of SUA compared to females. 5,6 Although SUA levels are usually higher in males than females, there is an increase in SUA ABSTRACT Background: Type 2 diabetes mellitus (Type 2 DM) is associated with cardiovascular complications, of which metabolic syndrome plays a prominent role. The metabolic syndrome is a cluster of cardiovascular risk factors characterized by central obesity, insulin resistance, dyslipidemia and hypertension. Hyperuricemia is gaining importance as cardiovascular risk factor and has role in renal and metabolic diseases. Our study was aimed to find out the prevalence of hyperuricemia and metabolic syndrome in type 2 DM and to evaluate association of hyperuricemia with metabolic syndrome. Methods: This observational longitudinal study was carried out on 150 patients of type 2 DM patients for determination of hyperuricemia and components of metabolic syndrome. Results: Metabolic syndrome was diagnosed in 68 patients (45.3%) with higher prevalence in males (53.4%) than females (33.9%). Hyperuricemia was found in 38 patients (25.3%) with higher prevalence in males (33%) than females (14.5%). Hyperuricemia and metabolic syndrome was found in 32 (21.3%) patients with higher prevalence among males (27.3%) than females (12.9%). The patients with hyperuricemia and metabolic syndrome compared to those without hyperuricemia and metabolic syndrome had higher mean age (63.16 Conclusions: Prevalence of hyperuricemia is higher in patients of type 2 diabetes with metabolic syndrome and is positively correlated with BMI, blood pressure and triglycerides and negatively correlated with HDL-C.

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Section: Discussionsupporting

confidence: 54%

The study of prevalence of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus

Mundhe

Mhasde

2016

Int J Adv Med

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“…An inverse relationship between low magnesium levels and high uric acid levels in diabetic retinopathy was also observed. A plausible mechanism for the observed results, of an inverse association between the increasing serum uric acid levels and Diabetes mellitus, may be related to the inhibition of the uric acid reabsorption in the proximal tubule by the high glucose levels in diabetic individuals [25,26].…”

Section: Methodsmentioning

confidence: 92%

The Association of Hypomagnesaemia, High Normal Uricaemia and Dyslipidaemia in the Patients with Diabetic Retinopathy

Navin¹

2013

JCDR

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Context: Diabetic retinopathy is fast becoming an important cause of a visual disability. The visual disability which results from diabetes is a significant public health problem; however, this morbidity is largely preventable and treatable. If it is managed with a timely intervention, the quality of life can be preserved. Aims:The objective of this study was to investigate the association of serum uric acid, magnesium and the lipid profile in diabetic retinopathy with Normal subjects and Diabetes mellitus without retinopathy, among the south Indian population. Settings and Design:The diabetic retinopathy patients were identified from the diabetic health camps which were held in rural areas, and they were compared with those with diabetes without complications and the normal subjects. Material and Methods:The diabetic retinopathy patients were compared with the healthy subjects and with diabetes without retinopathy. Furthermore, the Diabetic retinopathy patients were grouped as proliferative and non-proliferative, based on the fundoscopic findings. Magnesium, uric acid, FPG, fructosamine and the lipid profile were measured in the above groups and they were analyzed. Statistical Analysis:The statistical analysis was done by using the SPSS software, by applying the Student 't' test. Results:The mean serum magnesium concentration was observed to be low in the diabetic retinopathy group (1.43mg/dl) as compared to those in the controls and the diabetic subjects. The serum Uric acid concentration was high normal (4.84mg/ dl), which was associated with the dyslipidaemia in diabetic retinopathy. Conclusion:The poor glycaemic control in diabetes is associated with hypomagnesaemia, and increased uric acid concentration with dyslipidaemia, which can be an initial picture of the ongoing biochemical changes in the complication of diabetes, which can help in predicting the onset of diabetic retinopathy in diabetes.

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“…Our study showed similar prevalence of HU as documented in previous studies from different population. 4,5 In the previous literature, SUA levels were reported to increase with advancing age. 6,7 In the US study conducted from 1959 to 1960, the SUA values in males rose rapidly to a peak level at 20-24 years followed by a slight decline and a rise at 55 to 59 years.…”

Section: Discussionmentioning

confidence: 98%

A study of the association between hyperuricemia and knee osteoarthritis in the coastal Indian population

et al. 2018

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INTRODUCTIONHyperuricemia is an abnormally high level of uric acid in the blood. In the pH conditions of body fluid, uric acid exists largely as urate, the ion form. The amount of urate in the body depends on the balance between the amount of purines eaten in food, the amount of urate synthesised within the body (e.g. through cell turnover), and the amount of urate that is excreted in urine or through the gastrointestinal tract. In humans, the upper end of the normal range is 6mg/dL (360µmol/L) for women and 6.8mg/dL (400µmol/L) for men. ABSTRACTBackground: Hyperuricemia and knee osteoarthritis are common problems that affect the aging population and they have an increasing prevalence with obesity and hypertension. Epidemiologic and immunological studies have shown a possible relation between the two conditions. Uric acid is a common factor found in association with the evaluation and treatment of osteoarthritis. There are serious therapeutic implications, particularly in using traditional gout medications, for use in osteoarthritis treatment is to be explored in detail. Our diet contains a good amount of purine containing food stuffs. The common items which increase our uric acid levels are red meat, all alcoholic beverages, seafood and shellfish. Previous studies have shown an association between serum uric acid and generalized osteoarthritis, but with the limited studies on the evidence of association between serum uric acid and knee joint osteoarthritis. This study aims to know the association between serum uric acid levels and osteoarthritis of knee joint. Methods: This is a Cross-sectional analytical study including eight hundred and thirty patients (461 males, 369 females) in a population screening during a patient education program on joint pains. Their serum uric acid level, total count, differential count, erythrocyte sedimentation rate (ESR), height, weight, blood pressure, BMI and standing radiographs of affected knees were obtained. The presence of radiographic osteoarthritis of the knee was analyzed using Kellgren-Lawrence system. The patients were divided into cohorts with hyperuricemia and osteoarthritis and compared with the subjects without either of the problems. Results: Isolated knee joint osteoarthritis is present in 183 subjects (22%), hyperuricemia was present in 154 subjects (18.55%). There is a significant positive association present between isolated knee joint osteoarthritis and the highest level of serum uric acid (adjusted odd's ratio-2.24, 95% confidence interval-1.57-2.94). There is a significant positive association between high serum uric acid levels and progression of the knee joint osteoarthritis (highest level versus lowest level of serum uric acid odd's ratio-1.38, 95% confidence interval-0.96-2.74). Conclusions: It is concluded that knee joint osteoarthritis and its progression are associated with hyperuricemia.

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Plasma Uric Acid Level and Its Association With Diabetes Mellitus and Some Biologic Parameters in a Biracial Population of Fiji

Cited by 148 publications

References 0 publications

The study of prevalence of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus

The study of prevalence of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus

The Association of Hypomagnesaemia, High Normal Uricaemia and Dyslipidaemia in the Patients with Diabetic Retinopathy

A study of the association between hyperuricemia and knee osteoarthritis in the coastal Indian population

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