Plasma uric acid and plasma albumin in healthy subjects.

Ramsay, Lawrence E.; Mitchell, Theresa; Shelton, John

doi:10.1136/ard.36.4.374

Cited by 9 publications

(2 citation statements)

References 17 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We identified 71 publications that contained information on albumin in nondiseased individuals (4)(5)(6)(7)(8)(9)(12)(13)(14)(15)(16)18,19,(21)(22)(23)(24)(25)(26)28,29,32,33,35,36,45,46,(54)(55)(56)(58)(59)(60)(62)(63)(64)(65)(66)(67)(68)(69)(70)(72)(73)(74)(75)(76)(77)(78)(79)(80)(81)…”

Section: Number Of Studies Available For Analysismentioning

confidence: 99%

Reference distributions for the negative acute‐phase proteins, albumin, transferrin, and transthyretin: A comparison of a large cohort to the world's literature

Ritchie

Palomaki

Neveux

et al. 1999

J. Clin. Lab. Anal.

View full text Add to dashboard Cite

Clinical interpretation of the acute-phase proteins--albumin, transferrin, and transthyretin--has been hampered by the lack of accurate and precise methods for quantifying the levels and a stable and respected reference material. Now that these issues have been addressed, the community is faced with the need for credible age- and gender-specific reference values. The number of publications that address this issue, even for an analyte as familiar as albumin, is small and, in most cases, such publications lack the relevant data that would allow a combined experience to be created. We have identified 40 studies that meet our criteria: a description of the study participants' health status, of the statistical methodology, and of the laboratory technique and/or reference material used. Few of these studies reported values stratified by gender. A summary of the published median levels by age is presented for the three analytes, along with our own age- and gender-specific medians based on a large cohort. Ten of the studies presented a 95 percent reference range, in close agreement with ours where selection was based upon reported diagnosis rather than upon determination of individual health status. This meta-analysis provides support for the reliability of our recently published methodology and reference data for the clinical interpretation of individual albumin, transferrin, and transthyretin values. As with most laboratory measurements, clinical interpretation requires that other laboratory and clinical factors be considered.

show abstract

Section: Number Of Studies Available For Analysismentioning

confidence: 99%

Reference distributions for the negative acute‐phase proteins, albumin, transferrin, and transthyretin: A comparison of a large cohort to the world's literature

Ritchie

Palomaki

Neveux

et al. 1999

J. Clin. Lab. Anal.

View full text Add to dashboard Cite

show abstract

“…The positive significant correlation between Alb and UA in this study is in total agreement with that reported by Ramsay et al, who reported a positive correlation between plasma uric acid and plasma Alb (r=0.43, p<00.005, n=49) in healthy male subjects. 29 However, in COPD patients, there was considerable alteration in the correlation. Significant correlation between Alb and UA; Bil and UA; Alb and CAT; that was observed in the normal individuals was found lost in COPD patients while the correlation between SOD3 and CAT remained unaltered ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

Association between various antioxidants in normals and chronic obstructive pulmonary disease, their alteration and impact of smoking and disease on levels of antioxidants

Bhatia¹,

Ambade²,

Sontakke³

et al. 2019

Int J Res Med Sci

View full text Add to dashboard Cite

Background: There is total alteration of various antioxidants in response to the oxidative stress, which is one of the major patho-physiologic hallmarks in chronic obstructive pulmonary disease (COPD) development. This study aims to establish the correlation between different antioxidants in normals and COPD, study the alteration in the correlation due to COPD and smoking as well as the impact of COPD and smoking on antioxidants levels.Methods: Study comprises of 96 normals as group I and 96 COPD patients as group II. The antioxidants albumin (Alb), bilirubin (Bil), uric acid (UA) ceruloplasmin (Cp), glutathione peroxidase (GSHPx), catalase (CAT) and superoxide dismutase 3 (SOD3) were estimated.Results: Significant lower serum Alb, UA, SOD3 and increased serum Cp and GSHPx were found in Group II. Significant correlation was found between Alb and UA (r=0.24); Bil and UA (r=0.26); Alb and CAT (r=0.211) and SOD3 and CAT (r=0.318) in normals. However, these correlations were altered in COPD where Alb correlates with Bil (r=0.235); UA with CAT (r=0.203) and SOD3 with GSHPx (r=-0.27). The correlation between SOD3 and CAT remained unaltered. Similar correlation of UA with Alb and Bil was observed in nonsmoker normals and between SOD3 and CAT in smoker normals. In COPD, no correlation was seen in nonsmokers, while in smokers Alb correlates with Bil (r=0.316) and SOD3 with CAT (r=0.317).Conclusions: These alterations may have clinical ramifications in further understanding the pathogenesis of COPD and developing therapeutic approaches.

show abstract

Reference distributions for the negative acute-phase proteins, albumin, transferrin, and transthyretin: A comparison of a large cohort to the world's literature

Ritchie

Palomaki

Neveux

et al. 1999

J. Clin. Lab. Anal.

View full text Add to dashboard Cite

range, in close agreement with ours where selection was based upon reported diagnosis rather than upon determination of individual health status. This meta-analysis provides support for the reliability of our recently published methodology and reference data for the clinical interpretation of individual albumin, transferrin, and transthyretin values. As with most laboratory measurements, clinical interpretation requires that other laboratory and clinical factors be considered.

show abstract

Plasma uric acid and plasma albumin in healthy subjects.

Cited by 9 publications

References 17 publications

Reference distributions for the negative acute‐phase proteins, albumin, transferrin, and transthyretin: A comparison of a large cohort to the world's literature

Reference distributions for the negative acute‐phase proteins, albumin, transferrin, and transthyretin: A comparison of a large cohort to the world's literature

Association between various antioxidants in normals and chronic obstructive pulmonary disease, their alteration and impact of smoking and disease on levels of antioxidants

Reference distributions for the negative acute-phase proteins, albumin, transferrin, and transthyretin: A comparison of a large cohort to the world's literature

Contact Info

Product

Resources

About