Plasma tryptophan in humans with diabetic and senile cataracts

Cotlier, Edward; Sharma, Yog Raj; Zuckerman, Joel L.; Pucklin, J.E.; Teasley, Barry; Irvine, John

doi:10.1016/s0014-4835(81)80048-6

Cited by 20 publications

(2 citation statements)

References 12 publications

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“…2) tryptophan plasma levels are increased in both diabetic and nonSupported by grants: EY 02905-02; Eli Lilly 724A-41-57806; NIH 724A-41-48178. diabetic humans with senile cataracts (7,9). Reducing the plasma levels of tryptophan or preventing increased tryptophan penetration into lens may slow down cataract formation.…”

Section: Introductionmentioning

confidence: 99%

Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combined to diabetes

Cotlier

1981

Int Ophthalmol

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The prevalence of cataracts is significantly lower in patients with rheumatoid arthritis receiving aspirin (mean of 2,700 mgs daily for an average of 10.4 years) as compared to the matched population not receiving aspirin. Similarly, fewer cataracts were found among a population with diabetes and rheumatoid arthritis receiving aspirin (mean of 2,340 mgs daily for an average of 8.8 years) as compared to the matched population on no aspirin. The effects of aspirin on cataract formation may result from 1) lowering of plasma tryptophan levels and increased excretion of tryptophan metabolites, 2) inhibition of aldose reductase and sorbitol formation in the diabetic lens, 3) inhibition of tryptophan or kynurenine binding to lens protein.

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Section: Introductionmentioning

confidence: 99%

Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combined to diabetes

Cotlier

1981

Int Ophthalmol

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“…There is scant basic scientific evidence to explain such a protective effect. Acetylsalicylic acid has been found to lower plasma tryptophan (10), and plasma levels of tryptophan were found to be high in a group of patients with senile cataracts compared with a sample of patients with clear lenses (11)(12)(13).…”

Section: Discussionmentioning

confidence: 91%

Is Aspirin Use Associated With Lower Rates of Cataracts in Diabetic Individuals?

Klein

Moss

1987

Diabetes Care

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The relationship between a history of aspirin use and cataracts in diabetic individuals is examined in this report from a population-based study of 1370 individuals who developed diabetes after 30 yr of age. After pupil dilation lenses were examined for the presence and severity of nuclear sclerotic and posterior subcapsular cataracts and for surgical aphakia. A history of aspirin usage was obtained. Seven hundred eighty-four individuals had used aspirin in the month before the exam. There was no relationship between such usage and cataracts. For 338 people who reported using aspirin daily for at least 3 mo while having diabetes, there was also no association. These data suggest that aspirin usage as measured here has little effect on the prevalence of cataract in older-onset diabetic patients.

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