Plasma Trypsin in Patients with Steatorrhoea Due to Chronic Pancreatitis

Adrian, TE; Besterman, H S; Mallinson, C. N.; Galarotis, C; Bloom, Steve

doi:10.1042/cs054013pa

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“…2 patients in this study showed serum IRT within the normal range despite severe exocrine pancreatic insufficiency (duodenal trypsin <10% of lower limit of normal) associated with steatorrhoea and diabe tes. On the other hand, decreased serum trypsin levels have been reported to occur in diabetics (2,3,1,9), but these data have not been related to the exocrine pancreatic function of the same patients.…”

Section: Discussionmentioning

confidence: 86%

“…In ' Preliminary results were presented at the 12th Symposium of the European Pancreatic Club, Zurich, 1978. cases of chronic pancreatitis decreased values have been found (8). In a small number of patients, serum IRT measurements proved to be helpful in the differential diagnosis of steatorrhoea due to exocrine pancreatic insufficiency (1) and were claimed to be a new tool in evaluation of pancreatic function (4). In the present study the value of this test was exam ined in a larger number of patients.…”

Section: Introductionmentioning

confidence: 99%

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Trypsin Radioimmunoassay in the Diagnosis of Chronic Pancreatitis

et al. 1980

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Serum immunoreactive trypsin (IRT) determination has been recommended as a screening test in chronic pancreatitis. Using a commercial radioimmunoassay kit (RIA – gnost Trypsin; Behring-Werke, Marburg/Lahn, FRG) the interassay coefficient of variation was 26–44% for three different test sera. Gel filtration chromatography profiles revealed immunoreactivity in the position of ¹²⁵I-trypsin and ( < 50%) in the void volume. The test was evaluated in controls (n = 90), chronic relapsing pancreatitis (CRP;n = 60) and after total pancreatectomy (n = 5). In 65% of the CRP cases decreased IRT values were found, whereas during acute attacks of CRP supranormal and normal values were found. After total pancreatectomy IRT levels were undetectable. It is concluded that the sensitivity of this IRT test is limited and that the available test system needs improvement.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%