Plasma Trp/LNAA Ratio Increases During Chronic Ingestion of An α-lactalbumin Diet in Rats

Feurté, Sébastien; Gerozissis, Kyriaki; Regnault, Alain; Paul, François M.

doi:10.1080/1028415x.2001.11747377

Cited by 20 publications

(14 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In humans, primates, and rats, tryptophan decreases mild depressive symptoms and aggressive behavior 65, 66. Chronic tryptophan supplementation raises plasma tryptophan and central serotonin and potentiates SSRI effectiveness in rats 67, 68. Although contaminated tryptophan supplements were thought to cause eospinophilia myalgia syndrome,69 today, dietary manipulation of tryptophan or L-tryptophan/5-hydroxytryptophan supplementation is considered to be a safe intervention 65, 66, 68, 70…”

Section: Discussionmentioning

confidence: 99%

Evaluating the role of serotonin in hot flashes after breast cancer using acute tryptophan depletion

Carpenter¹,

et al. 2009

Menopause

View full text Add to dashboard Cite

Objective Among women with breast cancer, hot flashes are frequent, severe and bothersome symptoms that can negatively impact quality of life and compromise compliance with life-saving medications (e.g., tamoxifen, aromatase inhibitors). Clinicians' abilities to treat hot flashes are limited due to inadequate understanding of physiological mechanisms involved in hot flashes. Using an acute tryptophan depletion paradigm, we tested whether alterations in central serotonin levels were involved in the induction of hot flashes in women with breast cancer. Design This was a within subjects, double-blind, controlled, balanced, crossover study. Twenty-seven women completed two 9-hour test days. On one test day, women ingested a concentrated amino acid drink and encapsulated amino acids (no tryptophan) according to published procedures that have been shown to have specific effects on serotonin within 4.5 to 7 hours. On the other test day, women ingested a control drink. Serial venous blood sampling and objective hot flash monitoring were used to evaluate response to each condition. Results Response to acute tryptophan depletion was variable and unexplained by use of selective serotonin reuptake inhibitors, anti-estrogens, breast cancer disease and treatment variables, or genetic polymorphisms in serotonin receptor and transporter genes. Contrary to our hypothesis, hot flashes were not worsened with acute tryptophan depletion. Conclusions Physiologically-documented and self-reported hot flashes were not exacerbated by tryptophan depletion. Additional mechanistic research is needed to better understand the etiology of hot flashes.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluating the role of serotonin in hot flashes after breast cancer using acute tryptophan depletion

Carpenter¹,

et al. 2009

Menopause

View full text Add to dashboard Cite

show abstract

“…Feurté et al (113) showed that chronic supplementation of the diet of rats with a-lactalbumin leads to a stable increase of 40 % in plasma TRP:LNAA. Increasing plasma TRP:LNAA levels in rats were found to increase brain 5-HT levels, as dietary sub-chronic Trp supplementation (30 % increase in brain TRP:LNAA) in Sprague -Dawley rats resulted in an increase of 92 % in extracellular 5-HT levels in the dorsal hippocampus.…”

Section: Effects Of Acute and (Sub-)chronic Tryptophan Supplementatiomentioning

confidence: 99%

Food-derived serotonergic modulators: effects on mood and cognition

Hulsken

Märtin

Mohajeri³

et al. 2013

Nutr. Res. Rev.

View full text Add to dashboard Cite

The most frequently described drugs in the treatment of mood disorders are selective serotonin reuptake and monoamine oxidase (MAO) inhibitors, enhancing serotonin levels in the brain. However, side-effects have been reported for these drugs. Because serotonin levels in the brain are dependent on the availability of the food-derived precursor tryptophan, foods such as chicken, soyabeans, cereals, tuna, nuts and bananas may serve as an alternative to improve mood and cognition. Here we discuss the effects of high-or low-tryptophancontaining food, as well as plant extracts with a modest monoamine reuptake and MAO-A inhibition functional profile, on mood and cognition in healthy and vulnerable human subjects and rodents. Together the studies suggest that there is an inverted U-shaped curve for plasma tryptophan levels, with low and too high tryptophan levels impairing cognition, and moderate to high tryptophan levels improving cognition. This relationship is found for both healthy and vulnerable subjects. Whereas this relationship may also exist for mood, the inverted U-shaped curve for plasma tryptophan levels and mood may be based on different tryptophan concentrations in healthy v. vulnerable individuals. Animal studies are emerging and allow further understanding of effects and the mode of action of food-derived serotonergic components on mood, cognition and mechanisms. Ultimately, insight into the concentrations of tryptophan and other serotonergic components in food having beneficial effects on mood and cognition in healthy, but particularly vulnerable, subjects may support well-being in our highly demanding society.

show abstract

“…They focused on a-lactalbumin, because of its high TRP content in comparison to casein, and examined behavioral effects in humans ingesting a single meal. Feurte et al [28] and Orosco et al [8] subsequently extended the findings to rats, examining the differences between the two proteins chronically for their effects on the serum TRP ratio, and 5HT release by hypothalamic neurons. However, casein and lactalbumin are relatively high quality proteins (derived from cow's milk), and neither group considered the possibility that the effects might be substantially larger if a wider range of dietary proteins was examined (e.g., plant as well as animal proteins).…”

Section: Discussionmentioning

confidence: 95%

The Chronic Ingestion of Diets Containing Different Proteins Produces Marked Variations in Brain Tryptophan Levels and Serotonin Synthesis in the Rat

et al. 2011

View full text Add to dashboard Cite

Serotonin (5HT) synthesis in brain is influenced by precursor (tryptophan (TRP)) concentrations, which are modified by food ingestion. Hence, in rats, a carbohydrate meal raises brain TRP and 5HT; a protein-containing meal does not, but little attention has focused on differences among dietary proteins. Recently, single meals containing different proteins have been shown to produce marked changes in TRP and 5HT. The present studies evaluate if such differences persist when rats ingest such diets chronically. Male rats were studied that ingested diets for 9 days containing zein, wheat gluten, soy protein, casein, or α-lactalbumin (17% dry weight). Brain TRP varied up to eightfold, and 5HT synthesis fivefold among the different protein groups. TYR and LEU concentrations, and catecholamine synthesis rate in brain varied much less. The effects of dietary protein on brain TRP and 5HT previously noted after single meals thus continue undiminished when such diets are consumed chronically.

show abstract

Plasma Trp/LNAA Ratio Increases During Chronic Ingestion of An α-lactalbumin Diet in Rats

Cited by 20 publications

References 17 publications

Evaluating the role of serotonin in hot flashes after breast cancer using acute tryptophan depletion

Evaluating the role of serotonin in hot flashes after breast cancer using acute tryptophan depletion

Food-derived serotonergic modulators: effects on mood and cognition

The Chronic Ingestion of Diets Containing Different Proteins Produces Marked Variations in Brain Tryptophan Levels and Serotonin Synthesis in the Rat

Contact Info

Product

Resources

About