Plasma transfusion volume and liver transplantation safety

Alvarez, I.; Reichenberg, Stefan; Nicola, Sylvie di

doi:10.1111/trf.12321

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other virally inactivated plasmas, such as solvent/detergent (plasma pool), have been proven effective in TPE treatment. However because of its markedly reduced level of functional protein S activity, may predispose to the development of venous thrombosis, particularly after extensive, repeated TPE [14], in patients undergoing a liver transplant and patients with severe liver disease and known coagulopathies [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Methylene blue-treated plasma, versus quarantine fresh frozen plasma, for acute thrombotic thrombocytopenic purpura treatment: Comparison between centres and critical review on longitudinal data

Arroyo

Martínez

Amunarriz

et al. 2020

Transfusion and Apheresis Science

View full text Add to dashboard Cite

Introduction: Therapeutic plasma exchange (TPE) is the first-line treatment for acute thrombotic thrombocytopenic purpura (TTP). Methylene blue-plasma (MBP) has been used for over 20 years, but its efficacy in this setting remains controversial.Patients and methods: this is a comparative analysis of the experience of two Centres, with different plasma products, to evaluate their efficacy in TTP. One centre used quarantine plasma (QP), and MBP the other. We performed a retrospective longitudinal study, analysing the clinical files of TTP patients of a 13-year data evaluation period. Duration of treatment and transfusion parameters, medical record, laboratory testing, concomitant medication, and survival rate, were assessed for every episode. Results: During the study period, 12 (55.5 %) and 10 (45.5 %) new cases were treated with QP and MBP, respectively. There were no significant differences between the mean numbers of TPE processes, days elapsed from diagnosis to TPE, and plasma volume transfused. The QP TPE episodes of treatment were significantly associated with an increased time to recovery compared with MBP episodes of treatment (p = 0.004). Conclusion: MBP was as effective as QP in the treatment of TTP patients. Since recovery was more favourable when MBP was used, we consider MBP remains a suitable alternative to treat TTP patients.

show abstract