Plasma Total Antioxidant Activity in Comparison with Plasma NO and VEGF Levels in Patients with Metabolic Syndrome

Abstract

Decreased plasma total antioxidant activity, NO, and VEGF levels in patients with metabolic syndrome reflect significant endothelial dysfunction. This suggests that oxidation-reduction balance disorders might play an important role in this process.

Vascular Endothelial Growth Factor Therapy for the Kidney

“…Major sources of renal VEGF are tubular epithelial cells and podocytes, whereas endothelial cells and podocytes (acting in both autocrine and paracrine fashions) are major targets. Recent studies showed that renal levels of VEGF are altered in pathologic situations, such as chronic and acute renal ischemia, 12,13 diabetic-induced renal injury, 14,15 atherosclerosis, 16 or metabolic syndrome, 17 suggesting a potential pathologic role of this cytokine to promote profound microvascular dysfunctional and morphologic changes. Elegant seminal studies by the laboratories of Johnson and colleagues 18 and Basile and colleagues 19 showed that VEGF therapy reduced renal damage and protected the microvasculature in rodent models of chronic renal disease.…”

Promoter polymorphisms of the vascular endothelial growth factor gene are associated with metabolic syndrome susceptibility in Koreans

“…VEGF mRNA expression is elevated in both physiological and pathological states with increased angiogenesis (2). Patients with MetS have an associated increase in plasma VEGF levels (14). It is reasonable to hypothesize that VEGF is a likely risk factor for developing MetS.…”

“…Elevated plasma VEGF levels reportedly occur in patients with MetS (14). The components of MetS, such as body mass index (BMI), waist circumference (WC), blood pressure and inflammation are significantly correlated with plasma VEGF levels (15,16).…”

The concentration of uric acid in patients with metabolic syndrome and cardiovascular diseases

“…That is why allopurinol, which is xanthine oxidase inhibitor, causes the improvement of endothelial function in patients with hyperuricemia, by lowering the amount of produced free radicals [41][42][43][44].…”