Plasma tocopherol levels and tocopherol-lipid relationships in a normal population of children as compared to healthy adults

Farrell, Philip M.; Levine, Seymour; Murphy, M. Dianne; Adams, A. James Mc

doi:10.1093/ajcn/31.10.1720

Cited by 141 publications

(62 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Compared with results reported in previous studies in subjects without liver disease, [8][9][10][11][12] the correlation between RBC a-tocopherol concentrations and plasma Toc/TL ratios was not strong, although it was significant for all subjects. This finding suggests that liver injury or hepatic dysfunction, as well as lipid metabolic disorders, influences these plasma trations are not altered in CPH or CAH patients.…”

Section: Discussioncontrasting

confidence: 86%

“…The ratios of a-TL ratio) has also been used as a clinical index of plasma tocopherol to total lipid concentrations (Toc/TL ratios) in vitamin E status. 7,[10][11][12] However, to our knowledge, no pubplasma and liver were calculated. In both comparison patients lished reports compare hepatic a-tocopherol concentrations and patients with chronic persistent hepatitis and fatty liver, with RBC a-tocopherol concentrations or plasma Toc/TL rahepatic a-tocopherol concentrations were strongly correlated tios in adult patients with liver disease.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Assessment of hepatic vitamin E status in adult patients with liver disease

Nagita

Ando

1997

Hepatology

View full text Add to dashboard Cite

cally prevents liver injury from this or other causes. This No published reports compare hepatic a-tocopherol (adcontroversy is the result of many factors, including use of justed for hepatic lipid content) with indicators of blood different dosages of vitamin E, differences in the mechanisms a-tocopherol in adult patients with various liver diseases.of liver injury between experimental animals and clinical a-Tocopherol was simultaneously measured in liver biopsy subjects, and the lack of a reliable indicator of hepatic vitamin tissues and blood from 66 subjects (9 comparison patients E status. Because vitamin E-deficient red blood cells (RBCs) hospitalized for biliary tract surgery, 13 with chronic persisare fragile (as a result of hydrogen peroxidation), 7 RBCs are tent hepatitis, 9 with chronic aggressive hepatitis, 10 with considered a peripheral target tissue for vitamin E. RBC aacute hepatitis, 10 with cirrhosis, 7 with both cirrhosis and tocopherol has been assumed to be a reliable indicator of hepatic cell carcinoma, and 8 with fatty liver). Hepatic, erythvitamin E status in biomembranes. 8,9 The ratio of plasma arocyte, and plasma a-tocopherol concentrations were meatocopherol to total serum lipid concentration (plasma Toc/ sured, as were hepatic and serum lipids. The ratios of a-TL ratio) has also been used as a clinical index of plasma tocopherol to total lipid concentrations (Toc/TL ratios) in vitamin E status. 7,10-12 However, to our knowledge, no pubplasma and liver were calculated. In both comparison patients lished reports compare hepatic a-tocopherol concentrations and patients with chronic persistent hepatitis and fatty liver, with RBC a-tocopherol concentrations or plasma Toc/TL rahepatic a-tocopherol concentrations were strongly correlated tios in adult patients with liver disease. with hepatic triglyceride and total lipid concentrations (r Å Previous reports have shown diminished hepatic a-to-.72, P õ .001; and r Å .75, P õ .001, respectively); the copherol concentrations in alcoholic patients with cirrhorelationships (slopes) when hepatic a-tocopherol concentrasis, 13,14 but another report showed no correlation between tions were compared with hepatic triglyceride and total lipid the ratios of hepatic a-tocopherol to total hepatic lipid conconcentrations were similar in these patients and in all subcentrations (hepatic Toc/TL ratios) and inflammatory histojects. No strong correlations were found between hepatic and logical changes in alcoholic patients. 15 In our study (Nagita blood a-tocopherol parameters in all subjects. These results A, et al., unpublished observations, January 1997), hepatic suggest that hepatic a-tocopherol is present at similar concena-tocopherol concentrations were higher in pediatric patrations in triglycerides as well as total cholesterol and phostients with fatty liver (FL) than in comparison subjects and pholipids and that neither plasma Toc/TL ratios nor erythrowere strongly correlated with hepatic areas occupied by fat cyte a-tocopherol concentrations are usefu...

show abstract

Section: Discussioncontrasting

confidence: 86%

mentioning

confidence: 99%

Assessment of hepatic vitamin E status in adult patients with liver disease

Nagita

Ando

1997

Hepatology

View full text Add to dashboard Cite

show abstract

“…Normal ranges of serum tocopherol and cholesterol concentrations in American children are 7±21 mMaL and 2.7±6.5 mMaL, respectively (Farrell et al, 1978). Only 2 out of 77 children showed a-tocopherol concentrations 7 mMaL, and none showed cholesterol concentrations b 6.5 mMaL.…”

Section: Discussionmentioning

confidence: 94%

Vitamin A and vitamin E statuses of preschool children of socioeconomically disadvantaged families living in the midwestern United States

et al. 1997

View full text Add to dashboard Cite

Objective: To determine the vitamin A and vitamin E statuses of socioeconomically disadvantaged preschool American children. Design: Cross-sectional study of preschool children from socioeconomically disadvantaged families. Setting: Central Iowa, USA. Subjects: A group of 77 apparently healthy children was studied with the following characteristics: 5 mo±6 y; 37 males, 40 females; 56 non-Hispanic Caucasians, 3 Hispanics, 18 Afro-Americans. Methods: Modi®ed relative dose response (MRDR) test for vitamin A status assessment; serum retinol, atocopherol, cholesterol, and carotenoids; weight for age. Results: Although the mean weight for age was the 53rd percentile of the NCHS standard, a signi®cant number of children (P 0.006, w 2 ) were either markedly underweight or overweight. Ratios of 3,4-didehydroretinol to retinol (DRaR) were b 0.030 in 32% of the children. Mean serum retinol, a-tocopherol and cholesterol ( AE s.d.) were 1.09 AE 0.23 mMaL, 16.8 AE 6.3 mMaL and 4.01 AE 0.8 mMaL. Three children (3.9%) showed a serum retinol value`0.7 mMaL. One child with a serum retinol value`0.7mMaL and one additional child showed a ratio of a-tocopherol to cholesterol`1.44 mmolammol. The mean a-tocopherol to cholesterol ratio for the group (4.31 AE 1.71 mmolammol), however, was satisfactory. The only signi®cant (P 0.05) age-related changes were an increase in the serum cholesterol (P 0.005) and decrease in the a-tocopherol to cholesterol ratio (P`0.005) between the 0±2 y and the 2±4 y groups. Serum cholesterol (P 0.0165, two-tailed) and lycopene (P 0.004) concentrations of Afro-Americans were signi®cantly higher than those of Caucasians. Median serum concentrations of a-carotene and b-carotene were lower and, of lycopene, higher than those found in children studied in a national survey. Serum carotenoid concentrations generally increased with age. Conclusions: Larger percentages of underweight and overweight children and a signi®cant degree (32%) of inadequate vitamin A status were found in this group of socioeconomically disadvantaged children. AfroAmericans showed higher serum cholesterol and lycopene concentrations than did Caucasians, but otherwise were nutritionally similar. Age-related changes were small. Of nutritional parameters considered, the vitamin A status of socioeconomically disadvantaged segments of our population clearly needs attention. Sponsorship: NIH-HD27994, ISUaCDFINaUSDA 94-34115-0269 Descriptors: Modi®ed relative dose response (MRDR) test; vitamin A; vitamin E; cholesterol; carotenoids; weight for age

show abstract

“…The ratio of vitamin E to total serum lipid was calculated because vitamin E is known to partition from red cell membranes into serum containing elevated lipid concentrations (17)(18)(19)(20). Normal values for serum vitamin E to total lipid ratio for patients less than 12 y old is 0.6 mg/g and for older children, 0.8 mg/g (18,19).…”

Section: Methodsmentioning

confidence: 99%

d-α-Tocopheryl Polyethylene Glycol-1000 Succinate Enhances the Absorption of Vitamin D in Chronic Cholestatic Liver Disease of Infancy and Childhood

et al. 1992

View full text Add to dashboard Cite

ABSTRACT. Rickets and osteopenia, common problems in chronic childhood cholestasis, have been attributed to vitamin D malabsorption leading to reduced serum levels of 25(0H)-vitamin D. d-a-Tocopheryl polyethylene glycol-1000 succinate (TPGS), a water-soluble form of vitamin E, forms micelles at low concentration. We evaluated the potential role of TPGS in enhancing vitamin D absorption in eight children (aged 5 mo to 19 y) with severe chronic cholestasis (three extrahepatic biliary atresia, three nonsyndromic intrahepatic cholestasis, and two Alagille syndrome). To evaluate vitamin D absorption, the subjects received vitamin D3 1000 IU/kg (maximum dose of 50 000 IU); they then received the same dose of vitamin Dg mixed with TPGS (25 IU/kg). Serial serum vitamin D3 levels and areas under the curve were measured. All patients had enhanced absorption of vitamin D when it was administered in a mixture with TPGS. Mean area under the curve for serum vitamin D3 was 403.0 -C 83.1 nmol x h/L (155.6 f 32.1 ng x h/mL), with a mean rise above baseline of 13.5 f 1.8 nmol/L (5.2 f 0.7 ng/mL) with vitamin D/TPGS compared with no rise when vitamin D was given alone (both p < 0.001). Seven patients have been followed for at least 3 mo while receiving the vitamin D/TPGS combination. Those with initially low serum 25(OH)-vitamin D levels (C37.5 nmol/L or 15 ng/mL) had normalization (range 37.5-146 nmol/L) within 1 mo, whereas those with initially normal levels remained normal. While the patients were receiving vitamin D/TPGS, serum vitamin E to total lipid ratio either normalized or remained normal. In conclusion, 1 ) TPGS enhances vitamin D absorption in infants and children with severe chronic cholestasis and 2) the enhanced absorption of both vitamins is sufficient to normalize or maintain adequate levels of serum 25(OH)-vitamin D and vitamin E to total lipid ratio. (Pediatr Res 31: 146-150,1992) Abbreviations 25(OH)D, 25-hydroxy-vitamin D TPGS, d-a-tocopheryl polyethylene glycol-1000 succinate

show abstract

Plasma tocopherol levels and tocopherol-lipid relationships in a normal population of children as compared to healthy adults

Cited by 141 publications

References 18 publications

Assessment of hepatic vitamin E status in adult patients with liver disease

Assessment of hepatic vitamin E status in adult patients with liver disease

Vitamin A and vitamin E statuses of preschool children of socioeconomically disadvantaged families living in the midwestern United States

d-α-Tocopheryl Polyethylene Glycol-1000 Succinate Enhances the Absorption of Vitamin D in Chronic Cholestatic Liver Disease of Infancy and Childhood

Contact Info

Product

Resources

About