Plasma thrombomodulin level in very low birthweight infants at birth

Nako, Yasushi; Ohki, Yasushi; Harigaya, Akira; Tomomasa, Takeshi; Morikawa, Akihiro

doi:10.1111/j.1651-2227.1997.tb14817.x

Cited by 16 publications

(9 citation statements)

References 17 publications

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“…Specifically, half of their infants were full‐term, indicating that their results may not reflect the correlation between TM levels and preterm infants. Regarding pulmonary damage, no significant difference in plasma TM concentration was observed between VLBW infants who did or did not require mechanical ventilation, 32 indicating that their results were not consistent with ours. The mean gestational ages of their preterm infants who did or did not require mechanical ventilation were 28.4 and 30.7 weeks, respectively, showing little difference in the gestational ages.…”

Section: Discussioncontrasting

confidence: 80%

Protein C system in preterm babies with chronic lung disease: Prospective study

Kamamoto

Nakajima

Uchida

et al. 2022

Pediatrics International

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Background Chronic lung disease (CLD) is a major neonatal pulmonary disorder associated with inflammation. Recent studies have shown that protein C anticoagulant pathways, such as those for protein C (PC), protein S (PS), and thrombomodulin (TM), could be useful indices for reflecting pulmonary injury. However, the involvement of these factors in preterm infants with very low birthweight (VLBW) who have developed CLD remains to be investigated. Here, we investigated whether PC pathway‐related factors could predict the development of CLD in preterm infants with VLBW. Methods We collected plasma samples from 26 preterm infants with VLBW (13 each from those with and without CLD) at the time of birth and measured TM, PC, and PS levels in their plasmas. We analyzed prospectively the relationship between these factors in infants with and without CLD. Results There were significant differences in gestational age, birthweight, Apgar score (5 min), and duration of mechanical ventilation between the CLD and non‐CLD groups. No significant differences in the PC and PS levels at birth were observed between the two groups, whereas the TM levels in the CLD group were significantly higher than those in the non‐CLD group (P = 0.013). The TM levels correlated with gestational age and duration of mechanical ventilation. However, covariance analysis demonstrated that gestational age was significantly associated with TM levels, and consequently, development of CLD was not associated with TM level at birth. Conclusions Thrombomodulin, PC, and PS levels at birth could not predict the development of CLD in preterm infants with VLBW.

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Section: Discussioncontrasting

confidence: 80%

Protein C system in preterm babies with chronic lung disease: Prospective study

Kamamoto

Nakajima

Uchida

et al. 2022

Pediatrics International

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“…Концентрация тромбомодулина существенно повышена у новорожденных по сравнению со взрослыми (до 15 раз в первые дни жизни) [38]. Чем ниже гестационный возраст ребенка, тем выше уровень тромбомодулина [40], даже в условиях отсутствия перинатальной асфиксии. Полученные лабораторные данные указывают на общую подактивированность эндотелия у новорожденных в течение первых месяцев жизни, возникающую из-за механического стресса во время родов и последующей адаптации кровеносной системы, а также кратковременного состояния гипоксии, однако не ясно, имеет ли эта подактивированность какую-либо клиническую значимость.…”

Section: Abstract: Hemostasis Global Hemostasis Assays Laboratory unclassified

Laboratory aspects of hemostasis in neonates

Koltsova

Balashova

Panteleev

et al. 2019

Voprosy gematologii/onkologii i immunopatologii v pediatrii

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Newborns have high risks of thrombotic and hemorrhagic complications. Despite the fact that the overall frequency of thrombosis and bleeding in the general population of neonates is low, the risks of both thrombosis and hemorrhage are significantly increased when a newborn has some complications, including prematurity. The mechanisms underlying the onset of thrombotic and hemorrhagic complications in newborns are not fully understood and remain controversial. The hemostasis in newborns drastically differs from adult hemostasis and even from hemostasis in children older than a year. Nevertheless, despite the presence of quantitative and qualitative differences of almost all parameters of the hemostasis system from the parameters of adults, healthy newborns as a whole have clinically normal functional hemostasis without a tendency to coagulopathy or thrombosis. Apparently, the neonatal hemostasis system is in some alternative "balance", which differs from the "balance" of hemostasis in adults. The issue regarding the stability of this balance is still open. Due to the peculiarities of the newborn's hemostasis, clinical laboratory diagnostics of the coagulation disorders is very difficult, and the attending physician is forced to focus exclusively on the clinical picture. This review provides basic information on the neonatal hemostasis system, as well as an attempt to critically evaluate existing laboratory tests in terms of applicability for this group of patients.

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“…Our results were supported by several researchers. Nako et al 3 observed high plasma thrombomodulin levels in VLBW infants at birth, but its pathogenesis was unclear. Wiwanitkit 10 stated considerable controversy regarding the clinical role of thrombomodulin as a risk factor in severe preeclampsia.…”

Section: Dscussionmentioning

confidence: 99%

“…1,2 Plasma thrombomodulin levels in very low birth weight (VLBW) infants at birth show high value and the main factor responsible for this elevation may be the endothelial damage or low clearance rate of thrombomodulin. 3 Thrombomodulin is an endothelial cell surface glycoprotein forming a complex with thrombin. Thrombomodulin bound to thrombin has no procoagulant activity but has a capability to activate protein C approximately 1000-fold faster than thrombin does alone.…”

Section: Introductionmentioning

confidence: 99%