Plasma Throinboplastin Component (PTC) Deficiency: A New Disease Resembling Hemophilia

A Laboratory Study of the Carrier State in Classic Hemophilia 1

“…It has only recently been appreciated that the symptom complex originally termed hemophilia might result from a variety of abnormalities in the plasma. Thus, several groups of investigators described a disorder strikingly similar to hemophilia but due instead to a deficiency of another factor, variously called plasma thromboplastin component (38) or Christmas factor (39). Although the inheritance of Christmas disease superficially resembles that of hemophilia, the female carriers of the former may have hemorrhagic symptoms (26,40) and evidences of a partial deficiency of Christmas factor in their plasma (26,37,39,40 A second explanation for the variation in opinion concerning the detection of hemophilic carriers may reside in the technical methods used.…”

The Effect of Glass Upon the Activity of the Various Plasma Clotting Factors

“…Conley and Hartmann and their coworkers (7)(8)(9), and Quick and Epstein (10) presented further evidence for the glass activation of a plasma thromboplastin precursor. With the demonstration and characterization of two plasma thromboplastin precursors (17,18) the question arose as to which one the glass influenced. The recent experiments of Biggs, Douglas, and Macfarlane (11) indicate it is the antihemophilic B factor.…”

The Effect of Lanthanides and Actinides on Blood Coagulation. I. Evidence for and Properties of a New Serum Thromboplastic Factor*

“…It is precipitated at 50 to 66%o (NH4) 2SO4 saturation, in contrast to Factor XI (25 to 33%) (30), Factor IX (33 to 50%o) (30), and Factor XII (25 to 40%o) (31). Its relative instability also distinguishes it from Factors VII, IX, X, XI, and XII (31)(32)(33)(34)(35)(36)(37).…”