Plasma testosterone in narcotic addiction

Cushman, Paul

doi:10.1016/0002-9343(73)90202-7

Cited by 57 publications

(23 citation statements)

References 22 publications

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“…1964;Stoffer, 1968). In men, reduced libido and potency and delayed ejacula tion have been reported (Cushman, 1972(Cushman, , 1973. However, examination of the hormones in male heroin addicts has resulted in conflicting data.…”

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Pituitary-Gonadal Function in Heroin Addicts

Brambilla¹,

Sacchetti²,

Brunetta³

1977

Neuropsychobiology

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The present study deals with pituitary-gonadal function in male heroin addicts, 6 patients with schizophrenia and 31 with mild personality disorders. We examined the serum follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone levels at the moment of hospitalization (at the maximum of heroin addiction), and 48 h and 10 days later. FSH levels were definitely reduced in all the patients and did not change during the period of heroin withdrawal. The LH levels were reduced to a lesser extent, but significantly, and did not change after 10 days of abstinence from the drug. Testosterone levels were very low and increased in the schizophrenics during withdrawal, but not in the other addicts. The possible influence of heroin addiction on catecholamine metabolism in the central nervous system and, therefore, on the hypothalamic releasing factor and pitu-itary gonadotrophins, and the peripheral effect on testicular function are discussed.

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“…However, examination of the hormones in male heroin addicts has resulted in conflicting data. According to Cushman (1973) luteinizing hormone (LH) and testosterone levels are normal, with only 12% of the cases showing reduced secretion. Mendelson et al (1975), on the contrary, report a marked reduction in serum testosterone levels.…”

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Pituitary-Gonadal Function in Heroin Addicts

Brambilla¹,

Sacchetti²,

Brunetta³

1977

Neuropsychobiology

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“…Plasma testosterone levels have been revealed to be lower in opiate addicts, as compared with controls (26). Patients on lower doses of heroin and methadone have been found to have higher testosterone levels (27). In addition, various studies have shown the effect of heroin and methadone on testosterone levels in males.…”

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Sexual Dysfunction among Males with Opiate Dependence Undergoing Methadone Maintenance Therapy (MMT)

Zafarghandi

Nik

Birashk

et al. 2016

Int J High Risk Behav Addict

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“…GH, prolactin, insulin, testosterone and ovarian al terations (Azizi et ai, 1973;Bai et ai, 1974;Brambilla et ai, 1976Brambilla et ai, , 1977aBrambilla et ai, , b, 1978Cicero et ai, 1975;Cushman, 1971Cushman, , 1972Cushman, , 1973Cushman, , 1974Gaulden et ai, 1964;Santen, 1973;St offer, 1968). The variety of these alterations suggests that heroin acts on the hypothalamus, or on suprahypothalamic centers, to impair the secretion of neurotransmitters and releasing/ inhibiting factors responsible for pituitary and target gland function.…”

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Growth Hormone Response to Thyrotropin-Releasing Hormone and Gonadotropin-Releasing Hormone Stimulation in Heroin Addicts

et al. 1980

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Previous endocrine investigations have demonstrated the presence of multiple impairments of pituitary-target gland function in heroin addicts suggesting a possible hypothalamic involvement. Since the response of the pituitary to nonspecific stimuli is considered an expression of hypothalamic dysfunction, indicating a disconnection between the central nervous system and the anterior pituitary, we thought it worthwhile to study the GH response to stimulation with thyrotropin-releasing hormone (TRH) or gonadotropin-releasing hormone (GnRH) in heroin addicts. 23 male heroin addicts, aged 18-40 years, with histories of addiction to heroin alone from 8 months to 4 years, and daily i.v. heroin intakes between 200 and 2,500 mg of the drug (containing 18% of pure heroin) were studied. 8 patients received TRH 500 µg, GnRH 150 µg and 5 saline only, intravenously, and GH levels were assayed radioimmunologically in bloods taken 3Omin before, at the moment of stimulation and 15, 30, 60, 90 and 120 min thereafter. The results show normal basal GH levels. Stimulation with TRH and GnRH induced marked GH hypersecretion in 8 of the 18 patients examined. These results suggest that the hypothalamopituitary function may be impaired in heroin addiction.

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Plasma testosterone in narcotic addiction

Cited by 57 publications

References 22 publications

Pituitary-Gonadal Function in Heroin Addicts

Pituitary-Gonadal Function in Heroin Addicts

Sexual Dysfunction among Males with Opiate Dependence Undergoing Methadone Maintenance Therapy (MMT)

Growth Hormone Response to Thyrotropin-Releasing Hormone and Gonadotropin-Releasing Hormone Stimulation in Heroin Addicts

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