Plasma Testosterone, Estradiol, and Gonadotrophins in Hepatic Insufficiency

Kent, John R.; Scaramuzzi, Rex; Lauwers, Walter; Parlow, Albert F.; Hill, Michael R.; Penardi, Ruth; Hilliard, Jessamine

doi:10.1016/s0016-5085(73)80098-8

Cited by 97 publications

(34 citation statements)

References 18 publications

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“…There is also a significantly decreased plasma concentration of testosterone, as has been reported by others (3)(4)(5)(6). Several (18)(19)(20).…”

Section: Discussionsupporting

confidence: 80%

“…Previous studies in our and other laboratories have shown decreased plasma testosterone, metabolic clearance and production rates in cirrhosis (3)(4)(5)(6)(7). Moreover, we found a markedly abnormal testosteroneandrostenedione interconversion, with the redox pair ratio being shifted in favor of androstenedione (7).…”

supporting

confidence: 60%

“…The plasma levels of gonadotropins in cirrhosis, including our own measurements, have rather uniformly shown normal or elevated serum gonadotropins on random sampling (3,5,6) although Rosselin of the androgen-estrogen ratio in gonadotropin regulation in cirrhosis more extensive studies are necessary to verify this concept.…”

Section: Discussionmentioning

confidence: 78%

See 2 more Smart Citations

Conversion of Androgens to Estrogens in Cirrhosis of the Liver1

Gordon

Olivo

Rafil

et al. 1975

The Journal of Clinical Endocrinology & Metabolism

247

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The contribution, by peripheral conversion, of androstenedione and testosterone to the circulating estrogens was determined in men with cirrhosis of the liver. The conversion ratio of androstenedione to estrone, estradiol and testosterone and the conversion ratio of testosterone to estrone (but not estradiol) and androstenedione were significantly increased. The plasma concentrations of androstenedione and testosterone were increased and decreased respectively; the mean plasma concentration of androstenedione being similar to that found in normal women. The metabolic clearance rate of androstenedione was not altered in cirrhosis although the metabolic clearance rate of testosterone was decreased. The production rate of androstenedione was elevated while that of testosterone was reduced. The instantaneous contribution of plasma androstenedione to estrone and estradiol was increased in cirrhosis as was the contribution of testosterone to estrone (but not to estradiol). Thus the increased estradiol levels in cirrhosis result, in large part, from increased peripheral conversion from the androgens. The percent contribution of plasma testosterone to plasma androstenedione was decreased although the absolute amount derived by conversion was normal. The percent contribution of plasma androstenedione to plasma testosterone was increased sevenfold in cirrhosis. The fraction of the daily androstenedione production derived from the plasma testosterone pool was not significantly altered. However, a significant fraction of the daily production rate of testosterone was derived from androstenedione. Thus, 15% of the circulating testosterone is not secreted but is derived by peripheral conversion from androstenedione. Normal levels of gonadotropins were found in cirrhosis.

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“…There is also a significantly decreased plasma concentration of testosterone, as has been reported by others (3)(4)(5)(6). Several (18)(19)(20).…”

Section: Discussionsupporting

confidence: 80%

supporting

confidence: 60%

See 1 more Smart Citation

Conversion of Androgens to Estrogens in Cirrhosis of the Liver1

Gordon

Olivo

Rafil

et al. 1975

The Journal of Clinical Endocrinology & Metabolism

247

View full text Add to dashboard Cite

show abstract

“…We have studied the morphometric changes seen in zones 1 and 3 because hepatocytes from both zones are known to have different activities in relation to the orderly diffusion gradient of metabolites throughout the liver acinus [22][23][24]. Significant differences of hepatocyte morphology shown by this study are consistent with the different metabolic activities of hepatocytes in the two zones.…”

Section: Discussionsupporting

confidence: 53%

Quantitative Studies of Liver Atrophy After Portacaval Shunt in the Rat

Zaitoun

Apelqvist

Al-Mardini

et al. 2006

Journal of Surgical Research

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“…1 and 2). It has been reported that patients with chronic hepatic failure have low circulating T levels (22,23). In this study, there was no difference between cases of pancreatic carcinoma with obstructive jaundice and those with normal liver function.…”

Section: Discussioncontrasting

confidence: 41%

Low Serum Testosterone/Dihydrotestosterone Patients Ratio in with Pancreatic Carcinoma

et al. 1987

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Serum testosterone, its metabolite 5au-dihydrotestosterone, and the testosterone/dihydrotestosterone ratio were investigated in 22 male patients with proven pancreatic cancer, and compared with values from male patients with chronic pancreatitis (n = 21) and with nonpancreatic gastrointestinal tumors (n = 19). Testosterone and the testosterone/dihydrotestosterone ratio were significantly lower (p < 0.001) in the pancreatic cancer group when they were compared with the other two groups. There was no significant difference in the dihydrotestosterone values between cancer groups. A testosterone/dihydrotestosterone ratio of less than 5 clearly distinguished most of the patients (20/22) with cancer of the pancreas from those with other tumors or chronic pancreatitis. The results suggest an alteration in the serum androgen profile in these patients. Therefore, the testosterone/dihydrotestosterone ratio could be a useful marker in the diagnosis of pancreatic carcinoma in male patients. Key Words: Pancreatic carcinoma-Testosterone/dihydrotestosterone ratio in pancreatic carcinoma-Tumor marker.

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Plasma Testosterone, Estradiol, and Gonadotrophins in Hepatic Insufficiency

Cited by 97 publications

References 18 publications

Conversion of Androgens to Estrogens in Cirrhosis of the Liver1

Conversion of Androgens to Estrogens in Cirrhosis of the Liver1

Quantitative Studies of Liver Atrophy After Portacaval Shunt in the Rat

Low Serum Testosterone/Dihydrotestosterone Patients Ratio in with Pancreatic Carcinoma

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