Plasma TBARS, blood GSH concentrations, and erythrocyte antioxidant enzyme activities in regularly menstruating women with ovulatory and anovulatory menstrual cycles

Lutosławska, Grażyna; Tkaczyk, Joanna; Panczenko-Kresowska, B; Hϋbner-Woźniak, Elżbieta; Skierska, Elżbieta; Gajewski, Antoni

doi:10.1016/s0009-8981(03)00085-8

Cited by 32 publications

(21 citation statements)

References 16 publications

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“…It seems that the elevation of SOD activity caused the continuous increase of CAT and GSH-Px activities. Accordingly, we reconfirmed that SOD (Lutoslawska et al 2003), CAT, and GSH-Px (Qujeq et al 2004) protect liver tissue from oxidative damage such as TBARS. However, in experiment 2, GSH-Px and GST activities, and TBARS were significantly different by dietary PI value, and were not consistent according to PI value.…”

Section: Discussionmentioning

confidence: 59%

“…Under normal conditions, enzymic antioxidant activities exist as a safeguard against the accumulation of reactive oxygen species (Kamanli et al 2004;Qujeq et al 2004). Superoxide dismutase (SOD; EC 1.15.1.1), catalase (CAT; EC 1.11.1.6), glutathione peroxidase (GSH-Px; EC 1.11.1.9), glutathione-Stransferase (GST; EC 2.5.1.18), and glutathione reductase (EC 1.6.4.2) as well as glutathione are part of cellular antioxidant defences (Kuratko & Pence, 1991;Lutoslawska et al 2003). As an enzymic antioxidant system, SOD catalyses dismutation of the superoxide anion into H 2 O 2 .…”

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confidence: 99%

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The effects of polyunsaturated:saturated fatty acids ratios and peroxidisability index values of dietary fats on serum lipid profiles and hepatic enzyme activities in rats

et al. 2005

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Raising the dietary PUFA:saturated fatty acids (SFA) ratio has been recommended for the prevention of CVD. However, a high PUFA:SFA (P:S) ratio diet enhances oxidative stress because PUFA are highly susceptible to lipid peroxidation. Thus, we focused on the role of the dietary P:S ratio and peroxidisability index (PI) value on serum and liver tissue and investigated the effects of dietary P:S ratios (0·4, 1·0, and 4·8) with a fixed PI value (81) on serum lipid parameters and hepatic enzyme activities (experiment 1). To elucidate whether those phenomena were unique to the P:S ratio, we examined the effects of dietary PI values (36, 81, 126, and 217) with a constant P:S ratio (1·0) (experiment 2). Female Sprague-Dawley rats weighing 240 -280 g were fed experimental diets for 4 weeks. When dietary PI value was maintained at 81, serum HDL-cholesterol (HDL-C) increased with increasing dietary P:S ratio. When the P:S ratio was fixed at 1·0, HDL-C was the lowest with mid-low PI (MLPI) (PI value of 81). In both experiments, serum LDL-cholesterol:HDL-C ratio kept in the range of 0-2. The hepatic superoxide dismutase, catalase, and glutathione peroxidase (GSH-Px) activities and thiobarbituric acid reactive substance (TBARS) concentrations were the highest in the lowest dietary P:S ratio group (experiment 1). GSH-Px, glutathione-S-transferase, and TBARS were the lowest in rats fed the MLPI diet (experiment 2). In conclusion, these results indicate that a P:S ratio of 1·0 -1·5 and a PI value of 80-90 in the diet are within a favourable range to reduce the risk of CVD.

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Section: Discussionmentioning

confidence: 59%

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confidence: 99%

The effects of polyunsaturated:saturated fatty acids ratios and peroxidisability index values of dietary fats on serum lipid profiles and hepatic enzyme activities in rats

et al. 2005

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“…These data show that there are no one-way changes of antioxidant enzymes activity associated with ageing. A lower SOD activity observed in older women compared with the younger ones is difficult to explain in the light of the report of Lutosławska et al (25) who found that decreased estra diol concentrations were associated with increased SOD activity in erythrocytes. On the other hand, Massafra et al (26) found no differences in SOD activities in both phases of the menstrual cycle.…”

Section: Discussionmentioning

confidence: 80%

Age-Related Blood Antioxidant Capacity in Men and Women

Hϋbner-Woźniak¹,

Okęcka-Szymańska²,

Stupnicki³

et al. 2011

Journal of Medical Biochemistry

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Kratak sadr`aj: Cilj studije bio je da se odredi antioksidantni kapacitet u krvi kod mu{karaca i `ena u odnosu na njihovu starost. Ispitano je 19 mu{karaca (YM) i 19 `ena (YW) starosti 25-32 godine, kao i 11 mu{karaca (OM) i 11 ena (OW) starosti 63-71 godine, koji su svi bili neaktivni. Odre|eni su slede}i faktori: aktivnost superoksid dismutaze (SOD), glutation-reduktaze (GR), glutation-peroksidaze (GPX), katalaze (CAT), ukupni antioksidantni status (TAS) u eritrocitima, kao i retinol, alfa-tokoferol, mokra}na kiseli na i ukupne koncentracije proteina u plazmi. Izra~unat je zbir standardizovanih aktivnosti antioksidantnih enzima ka ko bi se uporedile promene u ukupnom kapacitetu anti oksi dantne odbrane u eritrocitima vezane za starosno doba. Nisu uo~e -ne zna~ajne promene vezane za starosno doba u aktivnosti SOD; srednja aktivnost CAT bila je vi{a kod starijih `ena i mu{karaca nego kod mla|ih ispitanika. Srednja aktivnost GPX bila je vi{a a aktivnost GR ni`a kod starijih ispitanika u pore|enju s mla|ima. Izra ~u nati ukupni antioksidantni enzimski kapacitet u eritrocitima dao je sli~ne vrednosti kod mla|ih i kod starijih ispitanika. Nisu uo~ene zna~ajne razlike u koncentracijama retinola i alfa-tokoferola u plazmi u odnosu na pol ili starosno doba. Ukupni nivo proteina u plazmi bio je zna~ajno ni`i kod mladih `ena i mu{karaca u pore|enju sa starijim ispitani cima. Zaklju~eno je da se ukupni enzimski antio ksidantni kapacitet u eritrocitima ne menja s godinama. Dobijeni rezultati jasno pokazuju da u procesu starenja u~estvuje vi{e faktora.

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“…[5][6][7] It was reported that depressed ovarian hormone secretion inhibited erythrocyte antioxidant system activity. 8 However, the researchers 9 investigated the effect of bilateral ovariectomy with estradiol and progesterone supplementation on lipid peroxidation in vitro studies suggested that estrogen inhibited the formation of lipid peroxides in liver tissues in vitro. 10 In addition, plasma malondialdehyde (MDA) levels increased after surgical menopause.…”

Section: Introductionmentioning

confidence: 99%

Lipid peroxidation in liver tissue of ovariectomized and pinealectomized rats: effect of estradiol and progesterone supplementation

Öztekin

Tiftik

Baltacı

et al. 2006

Cell Biochemistry & Function

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The present study aimed to determine the effect of estradiol-progesterone supplementation and pinealectomy on lipid peroxidation of liver tissue in ovariectomized rats. The study was carried out on 36 adult Sprague-Dawley female rats, which weighed 200-250 g. The rats were divided into 6 groups: Group 1: Sham Ovariectomy (Sham-Ovx), Group 2: Ovariectomy (Ovx), Group 3: Ovx + Estradiol-Progesterone supplementation (Ovx + H), Group 4: Sham Pinealectomy and Ovx (Sham Pnx -Ovx), Group 5: Ovx -Pnx, Group 6: Ovx -Pnx + H. Malondialdehyde (MDA), reduced form of glutathione (GSH) and glutathione peroxidase (GSH-Px) levels were determined in liver tissue of rats. The highest MDA levels and the lowest GSH-Px levels were determined in the ovariectomized-pinealectomized group, whereas the lowest MDA was in the Sham-Ovx group, and the highest GSH-Px levels were found in the Sham-Ovx and Ovx + Hormone supplemented group. Furthermore, the highest GSH levels were in group 1 and lowest levels were in group 5. The findings of this study demonstrate that ovariectomy led to lipid peroxidation in liver tissues of rats. Pinealectomy in addition to ovariectomy, increases lipid peroxidation, but, estradiol and progesterone supplementations to the ovariectomized-pinealectomized rats protect against lipid peroxidation to a significant extent.

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Plasma TBARS, blood GSH concentrations, and erythrocyte antioxidant enzyme activities in regularly menstruating women with ovulatory and anovulatory menstrual cycles

Cited by 32 publications

References 16 publications

The effects of polyunsaturated:saturated fatty acids ratios and peroxidisability index values of dietary fats on serum lipid profiles and hepatic enzyme activities in rats

The effects of polyunsaturated:saturated fatty acids ratios and peroxidisability index values of dietary fats on serum lipid profiles and hepatic enzyme activities in rats

Age-Related Blood Antioxidant Capacity in Men and Women

Lipid peroxidation in liver tissue of ovariectomized and pinealectomized rats: effect of estradiol and progesterone supplementation

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