Plasma Surface Modification of Rigid Contact Lenses Decreases Bacterial Adhesion

Wang, Ying‐Ming; Qian, Xuefeng; Zhang, Xiaofeng; Xia, Wei; Zhong, Lei; Sun, Zhengtai; Xia, Jingbo

doi:10.1097/icl.0b013e31829e8f73

Cited by 10 publications

(6 citation statements)

References 21 publications

(19 reference statements)

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“…However, we cannot rule out that newer technologies have improved lens surface properties with better wetting characteristics, which may reduce issues associated with surface problems. 19 , 74 , 75 …”

Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of Scleral Lenses for Keratoconus

Fuller

Wang

2020

Optom Vis Sci

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SIGNIFICANCE This study affirms the long-term safety and efficacy of scleral contact lens use in patients with keratoconus. PURPOSE This study aimed to evaluate the safety and efficacy of contemporary scleral contact lenses in the visual rehabilitation of the keratoconic population. METHODS A retrospective study of keratoconic subjects examined between 2013 and 2018 was conducted. Subjects were included regardless of age, sex, pre-existing morbidity, or scleral lens design. Only eyes fit successfully with scleral contact lenses for ≥1 year were included. Exclusion criteria were prior corneal surgery, dystrophy, degeneration, and trauma. RESULTS A total of 157 eyes of 86 subjects met the study criteria. The mean Keratoconus Severity Score at initial fitting was 3.6 ± 1.0. Lenses were gas-permeable and nonfenestrated, with a mean overall diameter of 15.8 ± 0.6 mm and 70.1% toric scleral periphery. Physiological adverse events occurred in 9.6% of eyes, including microbial keratitis (0.6%), phlyctenulosis (0.6%), corneal abrasion (1.3%), contact lens–induced acute red eye (1.3%), corneal infiltrative events (1.3%), pingueculitis (1.3%), and hydrops (3.2%). Lens-related adverse events were documented in 55.4% of eyes. Adverse events related to surface issues included poor wetting in 1.9%, handling in 3.8%, reservoir fogging in 7.0%, lens intolerance in 7.6%, deposit in 8.9%, and broken lenses in 26.1% of eyes. The most common management strategies involved refits (54.0% of interventions), patient reeducation (29.5%), medical treatment (5.5%), surgical referral (6.8%), adjustment to wear time (2.5%), surface treatment (1.2%), and lens replacement (0.6%). Best-corrected distance logMAR visual acuity improved significantly from a mean of 0.50 in spectacles to a mean of 0.08 in scleral lenses ( P < .0001). During the study period, 14.6% of eyes lost best-corrected scleral lens visual acuity, all from keratoconus progression. CONCLUSIONS Consistent with other groups, our study demonstrates excellent safety and efficacy of scleral contact lenses in subjects with keratoconus.

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Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of Scleral Lenses for Keratoconus

Fuller

Wang

2020

Optom Vis Sci

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“…Surface modification methods include the surface coating technique,[ 32 33 ] surface grafted modification,[ 34 35 ] plasma surface modification,[ 36 ] photochemical immobilization,[ 37 ] and layer-by-layer-self-assembly. [ 38 39 ] These techniques could be employed alone or combined with others.…”

Section: T Echnology Of S Urface mentioning

confidence: 99%

Surface Modification of Intraocular Lenses

Huang

Cheng

Chiu

et al. 2016

Chinese Medical Journal

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Objective:This paper aimed to review the current literature on the surface modification of intraocular lenses (IOLs).Data Sources:All articles about surface modification of IOLs published up to 2015 were identified through a literature search on both PubMed and ScienceDirect.Study Selection:The articles on the surface modification of IOLs were included, but those on design modification and surface coating were excluded.Results:Technology of surface modification included plasma, ion beam, layer-by-layer self-assembly, ultraviolet radiation, and ozone. The main molecules introduced into IOLs surface were poly (ethylene glycol), polyhedral oligomeric silsesquioxane, 2-methacryloyloxyethyl phosphorylcholine, TiO2, heparin, F-heparin, titanium, titanium nitride, vinyl pyrrolidone, and inhibitors of cytokines. The surface modification either resulted in a more hydrophobic lens, a more hydrophilic lens, or a lens with a hydrophilic anterior and hydrophobic posterior surface. Advances in research regarding surface modification of IOLs had led to a better biocompatibility in both in vitro and animal experiments.Conclusion:The surface modification is an efficient, convenient, economic and promising method to improve the biocompatibility of IOLs.

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“…Plasma treatments of contact lenses have relied on the techniques of plasma modification where the lenses are finished by plasma oxidation and by plasma deposition where a thin layer is deposited on the lens surface by plasma polymerization . Several authors investigated the modifications in the chemistry, topography, wettability and biocompatibility of the lens surface caused by plasma treatments but a large part of this research is described in technical notes and patents. The effect of the plasma on the lens surface depends on the processing conditions, namely, gas, power, pressure, and time.…”

Section: Introductionmentioning

confidence: 99%

Effect of plasma treatment on the performance of two drug‐loaded hydrogel formulations for therapeutic contact lenses

et al. 2014

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Although the plasma technology has long been applied to treat contact lenses, the effect of this treatment on the performance of drug-loaded contact lenses is still unclear. The objective of this work is to study the effect of nitrogen plasma treatment on two drug-loaded polymeric formulations which previously demonstrated to be suitable for therapeutic contact lenses: a poly-hydroxyethylmethacrylate (pHEMA) based hydrogel loaded with levofloxacin and a silicone-based hydrogel loaded with chlorhexidine. Modifications of the surface and the optical properties, and alterations in the drug release profiles and possible losses of the antimicrobial activities of the drugs induced by the plasma treatment were assessed. The results showed that, depending on the system and on the processing conditions, the plasma treatment may be beneficial for increasing wettability and refractive index, without degrading the lens surface. From the point of view of drug delivery, plasma irradiation at moderate power (200 W) decreased the initial release rate and the amount of released drug, maintaining the drug activity. For lower (100 W) and higher powers (300 W), almost no effect was detected because the treatment was, respectively, too soft and too aggressive for the lens materials.

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Plasma Surface Modification of Rigid Contact Lenses Decreases Bacterial Adhesion

Abstract: Plasma surface modification can significantly decrease bacterial adhesion to fluorosilicone acrylate contact lenses. This study provides important evidence of a unique benefit of plasma technology in contact lens surface modification.

Cited by 10 publications

References 21 publications

Safety and Efficacy of Scleral Lenses for Keratoconus

Safety and Efficacy of Scleral Lenses for Keratoconus

Surface Modification of Intraocular Lenses

Effect of plasma treatment on the performance of two drug‐loaded hydrogel formulations for therapeutic contact lenses

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