Plasma surface modification of poly (l-lactic acid) and poly (lactic-co-glycolic acid) films for improvement of nerve cells adhesion

Non-Thermal Plasma Surface Modification of Biodegradable Polymers

“…XPS revealed that oxygen containing functionalities are introduced and cell culture tests (3T3 fibroblasts) showed a higher cell attachment and proliferation on oxygen plasma-treated PLGA surfaces. As discussed in the previous paragraph on PLLA treated surfaces, Khorasani et al also investigated in the same paper the interaction between nervous tissue cells and plasma modified PLGA samples (Khorasani et al, 2008). Figure 4 shows that oxygen plasma treatment clearly improves attachment and growth of B65 cells, however, the effect of oxygen plasma treatment seems less pronounced as was the case for PLLA surfaces (see Figure 2).…”

“…The introduction of specific functional groups on the surface of PLA samples and the accompanying increase in wettability often have the aim to improve the cell-material interactions. These interactions between B65 nervous tissue cells and oxygen plasma-treated PLLA films were studied by Khorasani et al (Khorasani et al, 2008). Figure 2 shows optical photomicrographs of B65 cell attachment and growth on untreated and plasma-modified PLLA surfaces and it can clearly be observed that this oxygen plasma treatment substantially improves cell attachment and growth.…”

“…However, quite a few research articles deal with plasma modification of the copolymer PLGA (Khorasani et al, 2008, Hasirci et al, 2010, Khang et al, 2002, Park et al, 2007, Park et al, 2010, Safinia et al, 2007, Safinia et al, 2008, Shen et al, 2008, Wang et al, 2004. 50/50 PLGA films were modified in an oxygen plasma at low pressure and a decrease of the contact angle from 67° to below 40° after plasma treatment was observed.…”

Time-Gradient Nitric Acid Modification of CF Biofilm-Carrier and Surface Nature Effects on Microorganism Immobilization Behavior in Wastewater

“…Many references (4,12,14,16) show that material surface characteristics, such as hydrophilicity, chemistry, charge, roughness and rigidity, can greatly affect the adhesion capacity of different types of cells on material surfaces. And some efforts (7,13,15) show that the adhesion capacity of bacterial or eukaryotic cells could be improved if the material surface is modified to a better hydrophilicity state by producing various oxygen-based functional groups, such as hydroxyl group, carboxylic acid, carboxylic ester, ether, ketone, aldehyde, etc. However, a very hydrophilic surface can also hinder the microorganism adhesion because the oxygen-based functional groups give the carrier surface a strong negative charge, which repels the negatively charged cell surface with ionized amino acids (6).…”

Surface Modification of Poly(L-lactic acid) Nanofiber with Oligo(D-lactic acid) Bioactive-Peptide Conjugates for Peripheral Nerve Regeneration

“…Many investigators have attempted to add functional groups to PLA in order to enhance its biological activity via copolymerization or chemical grafting with other polymers [11], plasma treatment [12], chemical modification [13], and physical adsorption [14].…”