Plasma somatomedin and growth hormone values in children with protein-calorie malnutrition

Hintz, Raymond L.; Suskind, Robert M.; Amatayakul, Kosin; Thanangkul, Ousa; Olson, Robert E.

doi:10.1016/s0022-3476(78)80099-7

Cited by 241 publications

(78 citation statements)

References 6 publications

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“…Bhutta and others described severely depressed IGF-1 concentrations in young children hospitalized for persistent diarrhea in Pakistan, but rapid increases after nutritional recovery, with increments in IGF-1 correlating well with weight gain. 33 Low concentrations of IGF-1 have previously been described in children with acute shigellosis 34,35 and severe acute malnutrition, 36,37 with increases in IGF-1 seen upon nutritional recovery. 37,38 IGF-1 and IGF-2 were also found to be lower in patients with viral infections compared with healthy controls in a cohort of European adults 20-75 years of age.…”

Section: Discussionmentioning

confidence: 95%

Acute Illness is Associated with Suppression of the Growth Hormone Axis in Zimbabwean Infants

Jones¹,

Rukobo²,

Chasekwa³

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Abstract. Frequent infections contribute to childhood stunting in developing countries but the causal pathways are uncertain. We tested the hypothesis that intercurrent illnesses suppress the growth hormone axis through reductions in insulin-like growth factor 1 (IGF-1). In a birth cohort of 202 HIV-unexposed Zimbabwean infants, we analyzed data on 7-day illness recall and measured plasma interleukin-6, C-reactive protein, alpha-1-acid glycoprotein, and IGF-1 by enzyme-linked immunosorbent assay, at age 6 weeks, and then 3, 6, 12, and 18 months. Children with recent acute illness had lower IGF-1 concentrations than healthy children and IGF-1 correlated inversely (P 0.05) with inflammatory biomarkers at most time points between 3 and 18 months. Using path analysis, we showed that cough and fever had a predominantly indirect effect on suppressing IGF-1, through the acute-phase response, whereas diarrhea had a predominantly direct effect on IGF-1. Acute illness may therefore impact the growth hormone axis through both direct and indirect pathways.

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Section: Discussionmentioning

confidence: 95%

Acute Illness is Associated with Suppression of the Growth Hormone Axis in Zimbabwean Infants

Jones¹,

Rukobo²,

Chasekwa³

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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“…IGFBP-3 can exhibit either an inhibitory (4) or a potentiating (5) effect on IGF-I bioactivity in vitro, depending on its ability to alter the equilibrium between IGF-I and its receptor (5). Although IGF-I is thought to play an important role in postnatal growth (6)(7)(8)(9)(10)(11)(12)(13)(14)(15), there is disagreement among authors (16)(17)(18)(19) about the effects of postnatal age on plasma IGF-I in early infancy. The usefulness of obtaining plasma IGF-I concentrations in infancy is limited because normal values for this age group have not been established.…”

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confidence: 99%

Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein 3 during the First Year in Term and Preterm Infants

et al. 1995

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Plasma IGF-I and IGF-binding protein 3 (IGFBP-3) were determined by radioimmunoassay in term infants (n = 51) at 0, 2,4, 6, and 12 mo and preterm infants (n = 51) at -3 (28.4 wk postconceptional age), -2, -1.5, -1,0,2,4,6,9, and 12 rna from expected term. The effects of gestational age at birth (term or preterm) and study age were determined by repeated measures analysis of variance and Fisher's least squares difference. In preterm infants, IGF-I increased between -3 and 2 mo from 0.75 to 10.4 nM, decreased between 2 and 9 mo to 7.3 nM, and increased again between 9 and 12 mo to 10.1 nM (p < 0.0001), whereas IGFBP-3 increased relatively little from -3 to 0 rna (14.2 to 30.2 nM, p < 0.05) and plateaued from 2 to 12 mo (49.8 to 62.3 nM). At 0 rna, IGF-I and IGFBP-3 were the same in term and preterm infants, but preterm infants had higher IGF-I from 2 IGF mediate the growth-promoting actions of growth hormone in regulating the proliferation and differentiation of different cell types (1). These polypeptides which are structurally homologous to insulin also exert insulin-like metabolic effects. Both these effects are mediated through target cell surface receptors (2). Most tissues in the body produce IGF, and they are present in serum mostly bound to specific high molecular weight binding proteins (3). Of the six IGFBP that have been identified so far, IGFBP-3 is the major form present in the serum (1, 2) and demonstrates a high affinity for both IGF-I and IGF-II. IGFBP-3 can exhibit either an inhibitory (4) or a potentiating (5) effect on IGF-I bioactivity in vitro, depending on its ability to alter the equilibrium between IGF-I and its receptor (5).

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“…Growth failure in patients with PEM has been attributed to a deficiency in the generation of the somatomedins (3,4). Thus, measurements of somatomedin concentration may be an accurate index of nitrogen balance (flux) in such patients (5).…”

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confidence: 99%

“…Thus, measurements of somatomedin concentration may be an accurate index of nitrogen balance (flux) in such patients (5). Although there is general agreement that serum IGF-I concentrations are low in patients with kwashiorkor (3,4,6), there is still controversy concerning the circulating IGF-I levels (or activity) in marasmic (6, 7) individuals.…”

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confidence: 99%

Serum Insulin-Like Growth Factors I and II Concentrations and Growth Hormone and Insulin Responses to Arginine Infusion in Children with Protein-Energy Malnutrition before and after Nutritional Rehabilitation

et al. 1986

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ABSTRACT. Serum insulin, growth hormone (GH), insulin-like growth factors (IGFs) I and 11, cortisol, and albumin concentrations were measured in 15 children with kwashiorkor, 15 with marasmic-kwashiorkor, and 21 with marasmus, before and in the survivors, after nutritional rehabilitation, as well as in 10 underweight and eight normal Egyptian children. We also evaluated arginineinduced insulin and GH secretion. IGF-I concentrations were reduced in the three severely malnourished groups (0.07 2 0.03, 0.05 + 0.03, and 0.09 f 0.09 U/ml, respectively) but returned to normal after refeeding. IGF-I1 concentrations were low in the kwashiorkor (175 f 79 ng/ml), marasmic-kwashiorkor (1 11 2 57 ng/ml), and marasmic children (128 2 70.9 ng/ml) and returned to normal after nutritional rehabilitation. Basal GH levels were high in the three severely malnourished groups (21.9, 28.8, and 16.6 ng/ml, respectively) and returned to normal after refeeding (8.1, 6.5, and 6.0 ng/ml, respectively). GH responses to arginine were depressed in the three malnourished groups and improved significantly in marasmic-kwashiorkor and marasmic children after nutritional rehabilitation. Insulin responses to arginine were impaired in kwashiorkor, and marasmic-kwashiorkor children and improved significantly after refeeding. IGF-I levels correlated significantly with percent of expected weight ( r = 0.52, p < 0.001), percent of expected height ( r = 0.42, p < 0.001), and weight/ (height)' index ( r = 0 . 3 4 ,~ < 0.01). IGF-I levels correlated positively with insulin levels ( r = 0.421, p < 0.001) and negatively with cortisol concentrations ( r = -0.400, p <

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Plasma somatomedin and growth hormone values in children with protein-calorie malnutrition

Cited by 241 publications

References 6 publications

Acute Illness is Associated with Suppression of the Growth Hormone Axis in Zimbabwean Infants

Acute Illness is Associated with Suppression of the Growth Hormone Axis in Zimbabwean Infants

Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein 3 during the First Year in Term and Preterm Infants

Serum Insulin-Like Growth Factors I and II Concentrations and Growth Hormone and Insulin Responses to Arginine Infusion in Children with Protein-Energy Malnutrition before and after Nutritional Rehabilitation

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