Plasma Somatomedin Activity in Familial Laron's Dwarfism

Pierson, M; Grignon, G; Malaprade, D; Nabet, P; Hartemann, Philippe; Belleville, F.

doi:10.1203/00006450-197508000-00051

Cited by 3 publications

(3 citation statements)

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“…The se¬ cretory activity as well as the presence of adequate cellular structures have been demonstrated in pituitaries of foetuses at the 7th week of pregnancy with a peak at the 30th week. During the same time HGH has been demon¬ strated in foetus blood from the 10th week (Pierson et al 1973). Plasma HGH has been found to be surprisingly high in the last period of intra-uterine life with values even higher than in adults.…”

mentioning

confidence: 92%

Growth Hormone and Somatomedin Behaviour in the Newborn

Giordano

Foppiani

Minuto

et al. 1976

Acta Endocrinologica

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Human growth hormone (HGH) and somatomedin (Sm) concentrations have been studied in a group of newborns.Plasma HGH values were 41.17 \ m=+-\ 24.26 (sd) ng/ml (14.00-90.00 ng/ml) and the Sm value was 0.59 \ m=+-\0.43 (sd) U/ml (0.18\p=n-\1.8U/ml); the difference between these values and the ones observed in normal adults (2.45 \ m=+-\2.53 (sd) ng/ml and 1.16 \ m=+-\0.28 (sd) U/ml respectively) were statistically significant. While growth hormone values were higher than in normal adult controls, somatomedin was significantly decreased. It is possible that the dissociation between human growth hormone and somatomedin in newborn could reflect a reduced biosynthesis of the somatomedin-generating system and consequently a lack of a feed-back control on GH exerted by somatomedin.The influence of growth hormone (GH) on development is well established. However, the period when GH begins to exert its action has not been well defined (Rimoin et al. 1968). It has been demonstrated that during the intrauterine period, only a negligible amount of human growth hormone (HGH) is transferred from the mother to the foetus (Gillin et al. 1965;Laron et al. 1966) with almost no contribution of HGH from the mother to the development of the foetus.HGH has been measured in the foetal pituitary gland early in the first 3 months of pregnancy (Cornblalh 8c Parker 1965; Daughaday 1971). The se¬ cretory activity as well as the presence of adequate cellular structures have been demonstrated in pituitaries of foetuses at the 7th week of pregnancy

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mentioning

confidence: 92%

Growth Hormone and Somatomedin Behaviour in the Newborn

Giordano

Foppiani

Minuto

et al. 1976

Acta Endocrinologica

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“…Retardation associated with severe recurrent hypoglycemia has only been noted in one instance [55]. A mental retardation rate of 13.5% was noted in the European IGF-I treatment study group by anecdotal report, and did not relate to frequency or presence of symptomatic hypoglycemia [45].…”

Section: Sexual Developmentmentioning

confidence: 97%

IGF-I Deficiency Due to GH Receptor Deficiency

Al¹

1999

Horm Metab Res

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IGF-I deficiency may be primary due to defective synthesis, or secondary to GH receptor deficiency (GHRD) or defects in transduction of the GH-GHR signal. Cloning and sequencing of the GHR led to recognition that circulating GH binding protein (GHBP) was structurally identical to the extra-cellular domain of the GHR, and the identification of 33 mutations of the GHR in approximately half of the 250 patients that have been reported. This review explores the information provided about GHR function by various mutations, the population distribution of GHRD, the effects of this condition on mortality, growth, development, and metabolism, the effects of replacement therapy with recombinant human IGF-I, diagnostic issues, and the question of partial GH resistance.

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“…In animals, direct approaches to the pituitary gland have included organ perifusion, venous catheterization, and organ and tissue culture (Tashjian et al 1968;Steinberger et al 1973). In the human, direct approaches have been limited to investiga¬ tions of pituitary hormone content of glands obtained from abortuses or cadavers, from carvernous sinus catheterization during pituitary surgery and from tissue culture studies on foetal pituitaries or on a few adult human pituitaries removed at surgery (Nicoll 1972;Pasteéis 1972;Zimmerman et al 1974;Gala 1971;Pierson et al 1973;Gitlin 8c Biasucci 1969;Kohler et al 1969;Batzdorf et al 1971;Teraoka 1972;Peillon et al 1973;Espinoza 8c Neuss 1974;Sky 1er et al 1977). Foetal pituitary cells have been shown to synthesize and release polypeptide hormones in vitro as well as to respond to the presence of exogenous hormones and releasing factors (Siler-Khodr et al 1974).…”

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confidence: 99%

Tissue Culture Studies on Human Pituitary Tumours: Radioimmunoassayable Anterior Pituitary Hormones in the Culture Medium

et al. 1978

Acta Endocrinologica

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A tissue culture study was undertaken to determine if human non-functioning pituitary tumours secrete polypeptide anterior pituitary hormones in vitro and to study the spectrum of hormone release by functioning pituitary neoplasms. Fragments from 48 human pituitary tumours (from patients -2 with Cushing's disease, 1 with Nelson's syndrome, 5 with amenorrhoea-galactorrhoea, 10 with acromegaly and 30 with non-functioning pituitary tumours) and three normal human anterior pituitary glands (controls) were placed in tissue culture immediately after surgery. The in vitro release of human growth hormone (HGH), prolactin (Prl), thyrotrophin (TSH), adrenocorticotrophin (ACTH), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured by radioimmunoassays at the end of one week in culture. Clinical and pathological data were compared to hormone release patterns.

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Plasma Somatomedin Activity in Familial Laron's Dwarfism

Cited by 3 publications

References 0 publications

Growth Hormone and Somatomedin Behaviour in the Newborn

Growth Hormone and Somatomedin Behaviour in the Newborn

IGF-I Deficiency Due to GH Receptor Deficiency

Tissue Culture Studies on Human Pituitary Tumours: Radioimmunoassayable Anterior Pituitary Hormones in the Culture Medium

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