Plasma soluble Fas ligand concentration: Decrease in elderly men and increase in patients with gastric carcinoma

Ichikura, Takashi; Mizutani, Takashi; Uchida, Takefumi; Okura, Eiji; Ogawa, Takahisa; Mochizuki, Hidetaka

doi:10.3892/or.8.2.311

Cited by 14 publications

(14 citation statements)

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“…The slightly lower levels of sFasL in our control group compared with the reported values in other studies is explicable from the fact that a significant negative correlation exists between age and circulating levels of sFasL in healthy subjects (14), and that the mean age of our control group was over 70 year, the highest age among those of the control subjects in other studies. Also, it is interesting that the circulating levels of sFasL were not high in all cachexic patients with COPD, and that wide distribution of the levels of sFasL was observed in cachexic patients with COPD compared with the non-cachexic patients with COPD.…”

Section: Discussioncontrasting

confidence: 66%

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Circulating Levels of Soluble Fas Ligand in Cachexic Patients with COPD are higher than those in Non-Cachexic Patients with COPD

et al. 2005

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ObjectiveApoptosis may be involved in the pathophysiology of cachexia in patients with chronic obstructive pulmonary disease (COPD). The purpose of this study is to assess the potential role of the Fas-Fas ligand (FasL) system in cachexic patients with COPD.Patients and Methods We measured the circulating levels of soluble FasL (sFasL), with a newly developed, highly sensitive enzyme-linked immunosorbent assay system in seventy patients with COPD and forty-seven control subjects.Results The levels of sFasL in the COPD patients were significantly lower than those in the control subjects (46±29 vs. 55±28 pg/ml; p<0.05), whereas the levels of soluble Fas (sFas) remained unchanged between the two groups. The significant correlation between the levels of sFasL and sFas, observed in the control subjects (r=0.304; p<0.05), was absent in the COPD patients. Cachexic COPD patients with a relatively lower BMI (BMI <20 kg/m 2 , n=45) and %fat (%fat <20%, n=34), showed significantly increased levels of sFasL compared to non-cachexic COPD patients with a relatively higher BMI (BMI 20 kg/m 2 , n=25) and %fat (%fat 20%, n=36) (BMI; 51±33 vs. 36±15 pg/ml; p<0.05. %fat; 55±33 vs. 37±21 pg/ml; p<0.01), due to the inverse relationships between the body composition measurements and the levels of sFasL observed exclusively in the patients (BMI; r=-0.307; p<0.05. %fat; r=-0.283; p<0.05).Conclusion These results may suggest that the FasFasL system does not play a significant role in the potential triggers of enhanced apoptosis leading to skeletal muscle wasting and adipose tissue depletion in cachexic patients with COPD. (Internal Medicine 44: 1137-1143, 2005)

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Section: Discussioncontrasting

confidence: 66%

“…The patients had been clinically stable for at least 3 months and lacked clinical signs of exacerbation. Patients who had conditions known to affect serum sFasL levels, such as infection, heart failure, malignant diseases, were strictly excluded (12)(13)(14). The patients were not receiving any nutritional support therapy.…”

Section: Study Populationmentioning

confidence: 99%

Circulating Levels of Soluble Fas Ligand in Cachexic Patients with COPD are higher than those in Non-Cachexic Patients with COPD

et al. 2005

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“…Serum FasL concentrations have been shown to decrease with aging [29, 30], with higher serum FasL levels being associated with diseases related to imbalanced homeostasis of the immune cells [31–33]. As the follow-up results show, the most radical change in serum FasL levels in the present study had occurred by age 66, with the levels having decreased significantly by that age.…”

Section: Discussionsupporting

confidence: 45%

Declining Physical Performance Associates with Serum FasL, miR-21, and miR-146a in Aging Sprinters

Kangas

Törmäkangas

Heinonen

et al. 2017

BioMed Research International

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Aging is associated with systemic inflammation and cellular apoptosis accelerating physiological dysfunctions. Whether physically active way of life affects these associations is unclear. This study measured the levels of serum inflammatory and apoptotic molecules, their change over 10 years, and their associations with physical performance in sprint-trained male athletes. HsCRP, cell counts, HGB, FasL, miR-21, and miR-146a were measured cross-sectionally (n = 67, 18–90 yrs) and serum FasL, miR-21, and miR-146a and their aging-related associations with physical performance were assessed over a 10-year follow-up (n = 49, 50–90 yrs). The cross-sectional study showed positive age correlations for neutrophils and negative for lymphocytes, red blood cells, HGB, FasL, and miR-146a. During the 10-year follow-up, FasL decreased (P = 0.017) and miR-21 (P < 0.001) and miR-146a (P = 0.005) levels increased. When combining the molecule levels, aging, and physical performance, FasL associated with countermovement jump and bench press (P < 0.001), miR-21 and miR-146a with knee flexion (P = 0.023; P < 0.001), and bench press (P = 0.004; P < 0.001) and miR-146a with sprint performance (P < 0.001). The studied serum molecules changed in an age-dependent manner and were associated with declining physical performance. They have potential as biomarkers of aging-related processes influencing the development of physiological dysfunctions. Further research is needed focusing on the origins and targets of circulating microRNAs to clarify their function in various tissues with aging.

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“…This is in full agreement with data showing an age-dependent decrease in FasL plasma levels. 32 Reduction in the transcription of FasL can be considered another strategy to avoid an excessive depletion of lymphocytes via Fas/FasL apoptosis, the main factor responsible for so-called activation-induced cell death. The increased in vitro susceptibility of lymphocytes from aged donors to Fas-mediated apoptosis, reported in other studies, 33 may be explained at least in part by taking into account that the (excessive?)…”

Section: Discussionmentioning

confidence: 99%

Balanced Regulation of mRNA Production for Fas and Fas Ligand in Lymphocytes From Centenarians

et al. 2004

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Background-The functionality of the immune system during aging is crucial for protection against the most common age-related diseases. Apoptosis plays a central role in the senescence of the immune system, as evidenced by the increased plasma membrane expression of a key molecule like Fas protein. We analyzed the mRNA levels of different forms of Fas (total [tFas] and membrane [mFas]) and of its ligand (FasL) in peripheral blood lymphocytes from centenarians, the best example of successful aging, who were compared with young and middle-aged donors. Methods and Results-Using real-time polymerase chain reaction, we quantified mRNA for different forms of Fas and for FasL. In resting lymphocytes, mRNA for tFas, but not for mFas, significantly increases with age, whereas FasL mRNA significantly decreases. In vitro production of Fas/FasL mRNA after different stimuli was similar in cells from the 3 groups. Even if the percentage of Fas ϩ cells was higher than in the other groups, peripheral blood lymphocytes from centenarians had normal Fas-induced apoptosis, as revealed by flow cytometry. By ELISA, we observed that cells from centenarians showed normal in vitro production of the soluble form of Fas (sFas) and that plasma levels of such molecule were significantly higher in centenarians than in the other groups. Conclusions-Lymphocytes from centenarians are able to balance the production of proapoptotic (mFas and FasL) and antiapoptotic (sFas) molecules, whose proportions are likely crucial for the well-preserved immune functionality at the extreme limits of human life.

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Plasma soluble Fas ligand concentration: Decrease in elderly men and increase in patients with gastric carcinoma

Cited by 14 publications

References 0 publications

Circulating Levels of Soluble Fas Ligand in Cachexic Patients with COPD are higher than those in Non-Cachexic Patients with COPD

Circulating Levels of Soluble Fas Ligand in Cachexic Patients with COPD are higher than those in Non-Cachexic Patients with COPD

Declining Physical Performance Associates with Serum FasL, miR-21, and miR-146a in Aging Sprinters

Balanced Regulation of mRNA Production for Fas and Fas Ligand in Lymphocytes From Centenarians

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