Plasma sialidase activity in acute myocardial infarction

Hanson, Victor A.; Shettigar, U. R.; Loungani, Ramesh R.; Nadijcka, Mary

doi:10.1016/0002-8703(87)90307-3

Cited by 35 publications

(27 citation statements)

References 5 publications

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“…It has been reported that SA concentration rapidly increases during the pathological circumstances since tissue destruction and proliferation ocur [17] . We propose that, in accordance with the reports published by other investigators previously [18] , these changes in SA levels originate from the over secretion of the lipid-bounded sialic acid compounds exerted by the sialoprotein synthesis in the liver [18] and increased sialidase enzyme activity [35] during the inflammation [36] .…”

Section: Discussionsupporting

confidence: 89%

Laminektomi Yapılan Tavşanlarda Alfa-lipoik Asit Uygulamalarının Total Antioksidan Kapasite, Total Oksidan Kapasite, Paraoksonaz ve Total Sialik Asit Düzeyleri Üzerine Etkilerinin Araştırılması

Yildirim¹,

Yücetaş²,

Kaya³

et al. 2014

Kafkas Univ Vet Fak Derg

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The objective of this study is to investigate the effect of intramuscular administration of alpha-lipoic acid (ALA) on total antioxidant (TAS), total oxidant (TOS), paraoxonase (PON) and total sialic acid (TSA) levels in laminectomized rabbits. In the study, twenty four white New Zeeland rabbits weighing 3-4 kg were used. The investigation was carried out with three experiment and one control group consisting of six animals of each. No intervention has been done to the control group. Animals in the Group I received 50 mg/kg/day IM ALA (Thioctacid 600 T, M, EDA, Hamburg) without undergoing laminectomy. Group II underwent laminectomy; Group III underwent laminectomy and treated with IM ALA. The experiment lasted 45 days and blood samples were taken on 0, 15 th , 30 th , and 45 th days from the animals. TAS, TOS, PON and TSA levels were measured in the serum. We conclude that ALA treatment would be beneficial in laminectomized rabbits in order to suppress inflammatory process and to expedite recovery. Keywords: ALA, Laminectomy, TAS, TOS, PON, TSA, RabbitLaminektomi Yapılan Tavşanlarda Alfa-lipoik Asit Uygulamalarının Total Antioksidan Kapasite, Total Oksidan Kapasite, Paraoksonaz ve Total Sialik Asit Düzeyleri Üzerine Etkilerinin Araştırılması ÖzetBu çalışma, laminektomi yapılan tavşanlarda intramüsküler Alfa Lipoik Asit (ALA) uygulamasının total antioksidan kapasite (TAS), total oksidan kapasite (TOS), paraoksonaz (PON), ve total sialik asit (TSA) düzeylerini üzerine olan etkilerini araştırmak amacı ile yapıldı. Çalışmada, 3.5-4 kg ağırlığında 24 adet beyaz Yeni Zelanda erkek tavşan kullanıldı. Araştırma, herbiri 6 adet hayvan içeren 1 kontrol ve 3 deneme grubu olmak üzere 4 grup halinde yürütüldü. Kontrol grubuna hiçbir müdahale yapılmadı. Grup I'deki hayvanlara laminektomi yapılmaksızın 50 mg/ kg/gün İM ALA (Thioctacid 600 T, M EDa, Hamburg, Germany) enjekte edildi. Grup II'deki hayvanlara sadece laminektomi yapıldı. Grub III'e İM ALA+laminektomi uygulandı. Deneme toplamda 45 gün sürdürüldü. Denemenin 0., 15., 30.,ve 45. günlerinde vena auricularisten kan alındı. Elde edilen serum örneklerinde TAS, TOS, PON ve TSA düzeyleri belirlendi. Sonuç olarak, laminektomi yapılan tavşanlarda yangısal sürecin baskılanması ve iyileşmenin hızlandırılması için eksojen ALA kullanılmasının faydalı olabileceği kanısına varıldı. Anahtar sözcükler: ALA, Laminektomi, TAS, TOS, PON, TSA, Tavşan Investigation of the Effects of Alpha Lipoic Acid Application on INTRODUCTIONAlpha lipoic acid (ALA) has been described as a potent biologic antioxidant, a detoxifying agent, and a medicine for diabetes. It is used for the treatment of age-related cardiovascular and neuromuscular insufficiencies, and plays an important role as a modulator in various inflammatory signal pathways. Effect of ALA on inflammation originated from cytokines have been investigated and has been discovered that it was an inhibitor of NF-kappa β [1] , matrix metalloproteinase-13 (MMP-13) and growth factor-p (TGF J-3) [1] . It has been reported that antioxidant property...

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Section: Discussionsupporting

confidence: 89%

Laminektomi Yapılan Tavşanlarda Alfa-lipoik Asit Uygulamalarının Total Antioksidan Kapasite, Total Oksidan Kapasite, Paraoksonaz ve Total Sialik Asit Düzeyleri Üzerine Etkilerinin Araştırılması

Yildirim¹,

Yücetaş²,

Kaya³

et al. 2014

Kafkas Univ Vet Fak Derg

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“…It has been suggested that increased plasma sialidase activity in patients with AMI may be associated with clumps of desialylated erythrocytes that may alter flow in the microcirculation (82). The behaviour of sialidase present in the erythrocyte membrane could be more important in this regard.…”

Section: Erythrocyte Sialic Acidmentioning

confidence: 99%

Sialic acid in cardiovascular diseases

Nigam

Narain

Kumar

2006

Indian J Clin Biochem

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Sialic acid, the acylated derivatives of 9-carbon sugar neuraminic acid, present as terminal component of oligosaccharide chains of many glycoproteins and glycolipids, has been recognized to be involved in the regulation of a great variety of biological phenomena. Studies have shown that serum sialic acid predicts both coronary heart disease and stroke mortality and reflects the existence or activity of an atherosclerotic process. Most of the studies have shown an elevation in serum sialic acid concentration in coronary heart disease and a positive correlation between the raised serum sialic acid and the severity of the coronary lesions is observed. However, a few contradictory reports are also available. Racial differences in serum sialic acid have also been reported and correlated with international differences in the prevalence of atherosclerosis. Reduced sialic acid content of platelets, erythrocytes and lipoproteins may play important role in the pathogenesis of atherosclerosis. Elucidation of the mechanism of alternation in sialic acid concentration may throw more light on its potential clinical utility. Hence more studies are needed to designate sialic acid as a cardiovascular risk factor / marker.

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“…However, these cardiac markers are expressed in injured striated muscles as well, which limits their specificity. Nevertheless, a few studies showed that serum SA concentrations increase in patients with acute myocardial infarction, [6][7][8] and an earlier study demonstrated that the SA content of the sarcolemma from the ischemic subendocardial layer was significantly increased compared with that of the nonischemic subendocardial layer. 22 An elevated concentration of serum total SA in the blood might result either from the shedding or secreting of SA from the cell membrane surface, or release of cellular SA from the cell into the bloodstream because of cell damage after myocardial injury.…”

Section: Circulation Journal Vol66 November 2002mentioning

confidence: 99%