Plasma Short-Chain Fatty Acids and Their Derivatives in Women with Gestational Diabetes Mellitus

Ivanovová, Eliška; Piskláková, Barbora; Friedecká, Jaroslava; Krystynik, Ondrej; Friedecký, David; Karásek, David

doi:10.3390/separations8100188

Cited by 3 publications

(3 citation statements)

References 57 publications

(89 reference statements)

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“…Consistent with the above findings, our results also revealed a lower level of butyrate in women with GDM and a negative relationship between butyrate and GDM, both in T1 and T2. However, there was still at least one previous study reported that there was no significant difference in butyrate concentration between the GDM and control group [ 22 , 47 ]. Pregnant healthy women without GDM ( n = 20) and women with GDM in three different patterns ( n = 31, 31, 22, respectively) were included in the analysis and liquid chromatography coupled with mass spectrometry (LC-MS/MS) was used for SCFA detection [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, there was still at least one previous study reported that there was no significant difference in butyrate concentration between the GDM and control group [ 22 , 47 ]. Pregnant healthy women without GDM ( n = 20) and women with GDM in three different patterns ( n = 31, 31, 22, respectively) were included in the analysis and liquid chromatography coupled with mass spectrometry (LC-MS/MS) was used for SCFA detection [ 47 ]. Small sample sizes, different population characters and diet habits, sampling time, and detection methods for SCFAs may account for different study results.…”

Section: Discussionmentioning

confidence: 99%

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Butyrate and iso-butyrate: a new perspective on nutrition prevention of gestational diabetes mellitus

Han,

Wang,

Yan

et al. 2024

Nutr. Diabetes

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Background Dietary imbalance, such as a lower proportion of complex carbohydrates and a higher protein diet, may contribute to gestational diabetes mellitus (GDM) risks through their metabolisms. However, there is a lack of knowledge regarding the association between butyrate, iso-butyrate, and GDM, which are metabolisms of the two primary nutrients above. This study aimed to clarify the association of butyrate and iso-butyrate with GDM. Methods A nested case–control study was conducted based on the Beijing Birth Cohort Study (BBCS) from 2017 to 2018. Totally, 99 singleton women were involved (GDM: n = 49, control: n = 50). All participants provided blood samples twice (in their first and second trimesters). Gas chromatography-mass spectrometry (GC-MS) was used for butyrate and iso-butyrate detection. Unconditional logistic regression and receiver operating characteristic (ROC) curve analysis were used for statistical analysis. Results The results showed that butyrate in the first trimester was negatively correlated with GDM (odds ratio (OR): 0.00, 95% confidential interval (CI): 0.00–0.21, P = 0.008), and iso-butyrate in the second trimester was positively related to GDM (OR: 627.68, 95% CI: 40.51–9724.56, P < 0.001). The ratio (butyrate/iso-butyrate) was negatively associated with GDM, both in the first trimester (OR: 0.00, 95%CI: 0.00–0.05, P < 0.001) and in the second trimester (OR: 0.52, 95% CI: 0.34–0.80, P = 0.003). The area under the curve (AUC) using the ratio in the first trimester combined with clinical risk factors achieved 0.89 (95% CI: 0.83–0.95). Iso-butyrate in the second trimester combined with clinical risk factors achieved an AUC of 0.97 (95% CI: 0.92–1.00). Conclusions High iso-butyrate and low butyrate levels may be associated with an increased risk of GDM. As they are produced through dietary nutrient formation by gut microbiota, further studies on the association of dietary intake and butyrate or iso-butyrate concentration in plasma may help find a novel approach to nutritional intervention for GDM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Butyrate and iso-butyrate: a new perspective on nutrition prevention of gestational diabetes mellitus

Han,

Wang,

Yan

et al. 2024

Nutr. Diabetes

View full text Add to dashboard Cite

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“…Clinical and biochemical parameters were collected in the first trimester of pregnancy from the patients’ registry and the SCFA levels were extracted from a publication by Ivanovova et al. (2021) which describes the same cohort of women with GDM ( 28 ). Samples of feces were collected at two time points during the first and the third trimesters of pregnancy.…”

Section: Subjects Materials and Methodsmentioning

confidence: 99%

Specific gut bacterial and fungal microbiota pattern in the first half of pregnancy is linked to the development of gestational diabetes mellitus in the cohort including obese women

et al. 2022

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AimsGestation is linked to changes in gut microbiota composition and function. Since gestational diabetes mellitus (GDM) can develop at any time of the pregnancy, we stratified the women into four groups according to the time and test used for the diagnosis. We focused on the gut microbiota pattern in early pregnancy to detect changes which could be linked to later GDM development.MethodsWe collected stool samples from 104 pregnant women including obese individuals (first trimester body mass index median was 26.73). We divided the women into four groups according to routine screening of fasting plasma glucose (FPG) levels and oral glucose tolerance test (oGTT) in the first and third trimesters, respectively. We processed the stool samples for bacterial 16S rRNA and fungal ITS1 genes sequencing by Illumina MiSeq approach and correlated the gut microbiota composition with plasma short-chain fatty acid levels (SCFA).ResultsWe found that gut bacterial microbiota in the first trimester significantly differs among groups with different GDM onset based on unweighted UniFrac distances (p=0.003). Normoglycemic women had gut microbiota associated with higher abundance of family Prevotellaceae, and order Fusobacteriales, and genus Sutterella. Women diagnosed later during pregnancy either by FGP levels or by oGTT had higher abundances of genera Enterococcus, or Erysipelotrichaceae UCG-003, respectively. We observed significant enrichment of fungal genus Mucor in healthy pregnant women whereas Candida was more abundant in the group of pregnant women with impaired oGTT. Using correlation analysis, we found that Holdemanella negatively correlated with Blautia and Candida abundances and that Escherichia/Shigella abundance positively correlated and Subdoligranulum negatively correlated with plasma lipid levels. Coprococcus, Akkermansia, Methanobrevibacter, Phascolarctobacterium and Alistipes positively correlated with acetate, valerate, 2-hydroxybutyrate and 2-methylbutyrate levels, respectively, in women with GDM.ConclusionsWe conclude that there are significant differences in the gut microbiota composition between pregnant women with and without GDM already at the early stage of pregnancy in our cohort that included also overweight and obese individuals. Specific microbial pattern associated with GDM development during early pregnancy and its correlation to plasma lipid or SCFA levels could help to identify women in higher risk of GDM development.

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Pregnancy Lipid Profile and Different Lipid Patterns of Gestational Diabetes Treated by Diet Itself

Cibičková

Langova²,

Schovánek³

et al. 2022

Physiol Res

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The development of gestational diabetes mellitus (GDM) affects lipid metabolism during pregnancy. However, the magnitude of changes in lipid parameters is unclear. In addition, the patterns of these changes may vary based on the criteria selected for making the diagnosis of GDM. Thus, our aim was to compare the anthropometric and laboratory profiles of GDM-associated vs. GDM-free gestation with those of healthy non-pregnant women. We designed a cross-sectional study involving a group of females affected by GDM, a group of healthy pregnant controls and a group of healthy non-pregnant counterparts. GDM patients were divided into 3 subgroups according to the fulfilled diagnostic criteria, that is, those presenting with high fasting plasma glucose in the first trimester (subgroup 1), high fasting plasma glucose in the second trimester (subgroup 2) and high plasma glucose following oral glucose load in the second trimester (subgroup 3). The anthropometric and metabolic profiles of GDM subjects resembled the facets of metabolic syndrome (highest body mass index, waist circumference, C-peptide level, triglycerides) significantly more than the respective profiles of healthy non-pregnant women (p<0.0001). While total cholesterol (TC) (together with LDL-C and non-HDL-C) in pregnant women with GDM and without GDM did not differ, both groups had significantly higher levels of triglycerides (TG) than non-pregnant women (p<0.0001). Subgroup 1 had the highest fasting glucose level in the second trimester whereas subgroup 3 had the lowest fasting glucose level (p=0.019). Concentration of TG increased, being the lowest in subgroup 1 and the highest in subgroup 3 (p=0.006). Women with GDM had more pronounced features of metabolic syndrome than pregnant women without GDM. Both groups reached higher levels of TC (LDL-C, non-HDL-C) than non-pregnant controls and did not differ from each other. We found differences in TG and fasting glucose levels among different types of GDM

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Plasma Short-Chain Fatty Acids and Their Derivatives in Women with Gestational Diabetes Mellitus

Cited by 3 publications

References 57 publications

Butyrate and iso-butyrate: a new perspective on nutrition prevention of gestational diabetes mellitus

Butyrate and iso-butyrate: a new perspective on nutrition prevention of gestational diabetes mellitus

Specific gut bacterial and fungal microbiota pattern in the first half of pregnancy is linked to the development of gestational diabetes mellitus in the cohort including obese women

Pregnancy Lipid Profile and Different Lipid Patterns of Gestational Diabetes Treated by Diet Itself

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