Plasma Sfrp5 levels correlate with determinants of the metabolic syndrome in Chinese adults

Xu, Qian; Wang, Hongyan; Yang, Li; Wang, Jinzhi; Lai, Yerui; Gao, Lin; Lü, Ling; Yang, Gangyi; Liao, Xin; Xia, Fang; Liu, Hua; Li, Ling

doi:10.1002/dmrr.2896

Cited by 31 publications

(31 citation statements)

References 21 publications

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“…In a previous study, we reported that circulating Sfrp5, an adipokine, was significantly lower in MetS individuals and it may predict for MetS [22]. In the current study, we observed that circulating Alarin levels were significantly higher in MetS individuals.…”

Section: Discussionsupporting

confidence: 72%

High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome

Xia

Zhang

Yang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Alarin has been reported to be related with increased food intake and body weight. The relationship of circulating Alarin with insulin resistance or metabolic syndrome (MetS), however, is unknown. This study aimed to investigate the physiological role of Alarin and its association with MetS in humans. Methods: Newly diagnosed MetS patients (n=237) and age-matched healthy subjects (n=192) were recruited for this study. Oral glucose tolerance test, treadmill exercise, lipid infusions and euglycemic-hyperinsulinemic clamp (EHCs) were performed. Circulating Alarin and TNFα levels were measured by ELISA. Results: Circulating Alarin levels were significantly higher in MetS patients compared with healthy subjects (0.46 ± 0.22 vs. 0.41 ± 0.14 µg/L, P < 0.01). In all studied subjects, circulating Alarin levels were positively correlated with WC, blood pressure, FBG, triglyceride, HbA1c, HOMA-IR, AUC_glucose, and TNFα (P < 0.05 or P < 0.01). Multivariate logistic regression analyses revealed that circulating Alarin levels were correlated with MetS and insulin resistance. There was no significant change of circulating Alarin levels in the subjects with treadmill exercise for 45 min. In healthy individuals, however, glucose challenge, acute hyperglycemia and lipid infusions resulted in increased circulating Alarin levels, while acute hyperinsulinaemia transiently decreased circulating Alarin levels. Conclusion: The present study provides the evidence that circulating Alarin levels are associated with MetS and insulin resistance.

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Section: Discussionsupporting

confidence: 72%

High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome

Xia

Zhang

Yang

et al. 2018

Cell Physiol Biochem

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“…In a previous study, we reported that circulating Sfrp5, an adipokine, was significantly lower in MetS individuals, and it may predict MetS . In the current study, we observed that serum CTRP15 level was significantly higher in MetS individuals and was a positive predictor for MetS.…”

Section: Discussionmentioning

confidence: 99%

Circulating C1q/TNF‐related protein isoform 15 is a marker for the presence of metabolic syndrome

Wang

et al. 2018

Diabetes Metabolism Res

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Background C1q/TNF‐related protein isoform 15 (CTRP15) has been reported to be related to glucose and lipid metabolism, but the results are inconsistent. Metabolic syndrome (MetS) is a cluster of metabolic disorders. The aim of this study is to determine circulating CTRP15 levels in individuals with MetS and investigate the association among circulating CTRP15 and markers for MetS as well as insulin resistance. Methods A total of 341 individuals were recruited for this cross‐sectional study. These subjects were screened for MetS. Serum CTRP15 concentrations were measured by ELISA. Results Serum CTRP15 levels were significantly higher in MetS individuals relative to those of the healthy individuals. Circulating CTRP15 correlated positively with WHR, BMI, SBP, FAT %, 2 h‐BG, FIns, 2 h‐Ins, TG, FFA, HbA1c, HOMA‐IR, and AUCglucose, while negatively with HDL‐C and ISI. Multiple linear regression showed that HOMA‐IR and HDL‐C are independently related factors influencing serum CTRP15 concentrations. In addition, binary logistic regression analysis showed that serum CTRP15 concentrations were significantly related to MetS. When the mean concentrations of circulating CTRP15 in MetS subjects were stratified by the number of components of the MetS, circulating CTRP15 was found to increase progressively with increasing number of the MetS components. Finally, ROC curve analysis showed that the best cutoff values for circulating CTRP15 to predict MetS and insulin resistance were 63.6 and 64.0 μg/L. Conclusions Serum CTRP15 concentrations were associated with the key components of MetS and insulin resistance.

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“…SFRP5 has been previously linked to metabolic dysfunctions including obesity and diabetes, which were recognized to contribute to the CVD. Studies in humans showed an inverse association between SFRP5 and DM, 11 – 13 , 25 and Ouchi et al 10 also reported a protective role of SFRP5 in type 2 diabetes in mice. Conversely, other studies reported a positive 14 or no association 15 between SFRP5 and DM.…”

Section: Discussionmentioning

confidence: 96%

“…Secreted frizzled related protein 5 (SFRP5) is an emerging anti-inflammatory adipokine that belongs to the SFRP family, 10 and was reported to be implicated in obesity, insulin resistance, and other metabolic syndromes. 11 – 14 Several cross-sectional studies showed an inverse association between SFRP5 and diabetes mellitus (DM), 11 – 13 whereas another study reported the SFRP5 level was increased in DM 14 and one study found no association between SFRP5 and DM. 15 Similarly, data on SFRP5 and obesity are also controversial in both animal and human studies.…”

Section: Introductionmentioning

confidence: 99%

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Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study

Teliewubai¹,

Bai²,

Zhou³

et al. 2018

CIA

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ObjectiveSecreted frizzled related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that is implicated in metabolic and cardiovascular disease (CVD). However, little is known about the relevance of SFRP5 with asymptomatic hypertensive target organ damages (TODs). We aimed to investigate the association between SFRP5 and TOD in a large population.Clinical trial registrationNCT02368938.MethodsA total of 1,745 community-dwelling elderly subjects aged over 65 years from northern Shanghai were recruited in the study. Plasma SFRP5 level was measured by an enzyme-linked immunosorbent assay. Asymptomatic TODs, including left ventricular mass index, peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity, carotid intima–media thickness (CIMT), pulse wave velocity (PWV), estimated glomerular filtration rate, and urinary albumin–creatinine ratio were evaluated.ResultsPlasma SFRP5 level was negatively associated with body mass index, waist/hip ratio, and fasting blood glucose (all P<0.001). Men, compared with women, had lower plasma SFRP5 level (4.19 vs 5.13 ng/mL, P<0.001). Additionally, plasma SFRP5 level was lower in diabetics than in those without diabetes (4.30 vs 4.81 ng/mL, P<0.05). Furthermore, an inverse association was observed between SFRP5 and PWV and CIMT (both P<0.05). Lastly, the multivariate logistic regression analysis showed lower SFRP5 level was significantly associated with increased arterial stiffness in the elderly (odds ratio 0.83, 95% confidence interval 0.71 to 0.99 per 1 standard deviation increase, P<0.05).ConclusionPlasma SFRP5 level was inversely correlated with conventional cardiovascular risk factors, and low plasma SFRP5 was also significantly associated with arterial stiffening in the elderly Chinese population.

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Plasma Sfrp5 levels correlate with determinants of the metabolic syndrome in Chinese adults

Abstract: We conclude that Sfrp5 may be an adipokine that is associated with the pathogenesis of MetS in humans.

Cited by 31 publications

References 21 publications

High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome

High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome

Circulating C1q/TNF‐related protein isoform 15 is a marker for the presence of metabolic syndrome

Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study

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