Plasma serotonin level after 1 day of fluoxetine treatment: A biological predictor for antidepressant response?

Alvarez, Jean-Claude; Gluck, Nathan; Fallet, Alain; Chevalier, Jean-François; Advenier, C.; Spreux‐Varoquaux, Odile

doi:10.1016/s0006-3223(97)87785-2

Cited by 5 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with these experimental observations, secondary osteoporosis has been reported to be an off‐target negative effect caused by the use of SSRIs in humans . SSRI users have substantially lower values of serum serotonin compared with non‐SSRI users, as shown in our study as well as by others . Our results, also in agreement with several other studies, show that those taking SSRI fall more often and have increased risk for fractures.…”

Section: Discussionsupporting

confidence: 93%

“…(31,32) SSRI users have substantially lower values of serum serotonin compared with non-SSRI users, as shown in our study as well as by others. (33,34) Our results, also in agreement with several other studies, (20,35,36) show that those taking SSRI fall more often and have increased risk for fractures. Our results were only statistically significant for increased risk for incident fractures and nonvertebral osteoporotic fractures in those taking SSRIs, and lost its significance when adjusted for other risk factors.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

High Serum Serotonin Predicts Increased Risk for Hip Fracture and Nonvertebral Osteoporotic Fractures: The MrOS Sweden Study

Kristjánsdóttir

Lewerin

Lerner

et al. 2018

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Because several studies have implicated serotonin as a regulator of bone mass, we here explore its potential association on fracture risk and falls, as on bone mineral density (BMD) and muscle strength, in humans. Serum levels of serotonin were analyzed in 950 men (aged 69 to 81 years), participating in the Gothenburg part of the population‐based study MrOS Sweden. Men taking selective serotonin reuptake inhibitors (SSRIs) had a mean value of 31.2 μg/L compared with 159.4 μg/L in those not taking SSRIs. SSRI users were excluded from further analysis. During 10‐year follow‐up, 224 men exhibited fractures, including 97 nonvertebral osteoporotic fractures (57 hip fractures), and 86 vertebral fractures. Serotonin was associated with hip fracture in linear analysis (hazard ratio [HR] = 1.27, 95% confidence interval [CI] 1.03–1.58) and to all fractures in a nonlinear manner, when quintiles of serotonin was included in quadratic terms (HR = 1.12, 95% CI 1.04–1.21). Men in serotonin quintile 5 had, in multivariable analysis, a HR of 2.30 (95% CI 1.31–4.02) for hip fracture and 1.82 (95% CI 1.17–2.85) for nonvertebral fractures compared with men in quintiles 1 to 4. Men in quintile 1 had, in multivariable analysis, a HR of 1.76 (95% CI 1.03–2.99) for nonvertebral fractures compared with men in quintiles 2 to 4. No association was found with vertebral fractures. Individuals in serotonin quintile 1 had higher prevalence of falls compared with quintiles 2 to 5 (odds ratio = 1.90, 95% CI 1.26–2.87). Serotonin was positively associated with hand‐grip strength (r = 0.08, p = 0.02) and inversely with hip BMD (r = −0.10, p = 0.003). To assess the association between SSRIs and falls and fractures, the total MrOS Sweden cohort was examined (n = 3014). SSRI users (n = 90) had increased prevalence of falls (16% versus 33%, p = 0.0001) and increased rate of incident fractures (28.0 versus 44.7 per 1000 person‐years, p = 0.018). We present novel data showing that high levels of serotonin predict an increased risk for hip fracture and nonvertebral osteoporotic fractures. © 2018 American Society for Bone and Mineral Research.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

High Serum Serotonin Predicts Increased Risk for Hip Fracture and Nonvertebral Osteoporotic Fractures: The MrOS Sweden Study

Kristjánsdóttir

Lewerin

Lerner

et al. 2018

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

show abstract

“…In this regard, several studies on human platelets suggest that a high pretreatment platelet 5-HT content is associated with a later poor therapeutic outcome to antidepressants (Figueras et al, 1999;Mü ck-Seler et al, 2002;Castrogiovanni et al, 2003). In addition, some authors suggest that plasma 5-HT levels after 1 day of fluoxetine treatment may predict the antidepressant response, as responders showed significantly lower concentrations than nonresponders (Alvarez et al, 1999b). Whether these findings are true for fluoxetine-treated aggressive dogs was not addressed in the present study but it might represent an interesting question to assess in future studies.…”

Section: Discussionmentioning

confidence: 75%

“…, 2003). In addition, some authors suggest that plasma 5‐HT levels after 1 day of fluoxetine treatment may predict the antidepressant response, as responders showed significantly lower concentrations than nonresponders (Alvarez et al. , 1999b).…”

Section: Discussionmentioning

confidence: 99%

Effect of fluoxetine on blood concentrations of serotonin, cortisol and dehydroepiandrosterone in canine aggression

Rosado

García-Belenguer

León³

et al. 2010

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

Canine aggression directed towards people is the most frequent reason for referral to behaviour practices. The serotonergic system and the hypothalamic-pituitary-adrenal (HPA) axis are believed to play an important role in controlling aggression. The selective serotonin reuptake inhibitor fluoxetine is the most commonly used drug in canine aggression. The aim of the present study was to assess the effect of a 30-day-long fluoxetine treatment on the peripheral serotonergic system and the HPA axis in canine aggression. To this end, the concentrations of serum serotonin (5-HT) and plasma cortisol and dehydroepiandrosterone (DHEA) were analysed in a group of aggressive (n = 22) and nonaggressive dogs (n = 9) during pre- (day 0) and posttreatment (day 30) conditions. Treatment caused a significant decrease in 5-HT concentrations (46% in the aggressive group and 32% in the control group). There was a trend towards a rise of DHEA/cortisol ratio values after treatment both in the aggressive and the control group. The determination of blood 5-HT and the DHEA/cortisol ratio could have important clinical applications in the future for deciding which animals might benefit from a given treatment as well as for monitoring the response. Further large-scale studies with this aim should be carried out to obtain sound conclusions.

show abstract

“…Although SSRIs are widely used in the clinical practice for ameliorating FMS symptoms, only few studies conducted to estimate the changes in serum serotonin concentration following therapy; Alvarez, et al (1999) reported that treatment of depressed patients with fluoxetine (20mg/day) resulted in significant reduction of serum serotonin to 17.5% and 34.1% of its pre-treatment value after 14 days and 28 days of treatment respectively [34]. The possible explanation for this finding is that fluoxetine and its active metabolite norfluoxetine induce blockade of platelet serotonin uptake mechanism after 28 days leading to dramatic decrease in serum serotonin level, providing at the same time significant amount of serotonin to the brain resulting in improving FMS symptoms [35].…”

Section: Discussionmentioning

confidence: 99%

Adjuvant Use of Melatonin with Fluoxetine for Management of Fibromyalgia

Hussain¹,

Al-Khalifa²,

Jassim³

2013

Med-Science

View full text Add to dashboard Cite

show abstract

Plasma serotonin level after 1 day of fluoxetine treatment: A biological predictor for antidepressant response?

Cited by 5 publications

References 0 publications

High Serum Serotonin Predicts Increased Risk for Hip Fracture and Nonvertebral Osteoporotic Fractures: The MrOS Sweden Study

High Serum Serotonin Predicts Increased Risk for Hip Fracture and Nonvertebral Osteoporotic Fractures: The MrOS Sweden Study

Effect of fluoxetine on blood concentrations of serotonin, cortisol and dehydroepiandrosterone in canine aggression

Adjuvant Use of Melatonin with Fluoxetine for Management of Fibromyalgia

Contact Info

Product

Resources

About