Plasma selenium levels in Turkish women with polycystic ovary syndrome

Coşkun, Ayhan; Arıkan, Tuğba Atılan; Kılınç, Metin; Arıkan, Deniz Cemgil; Ekerbiçer, Hasan Çetin

doi:10.1016/j.ejogrb.2013.01.021

Cited by 64 publications

(48 citation statements)

References 43 publications

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“…Of those, two were excluded after full text review because they did not focus on the serum levels of trace elements [40,41]. The six articles [42][43][44][45][46][47] that were included in the systematic review presented data on serum or plasma levels of chromium, cobalt, copper, manganese, nickel, selenium, vanadium, and zinc.…”

Section: Discussionmentioning

confidence: 99%

“…One single study evaluating plasma selenium in PCOS reported lower levels in the PCOS group in comparison with controls [44] (Fig. 2).…”

Section: Seleniummentioning

confidence: 97%

“…Table 1 describes the characteristics of the six studies included in the systematic review. One study focused on a Chinese population [42], another study on women from India [46], and four on Turkish women [43][44][45]47]. All were casecontrol studies and used the 2003 Rotterdam criteria [2] to diagnose PCOS.…”

Section: Study Selectionmentioning

confidence: 99%

“…Of the six studies, two were included in the systematic review, but not in the meta-analysis [42,44]: one described that decreased zinc levels were found in PCOS compared to controls; however, it was not included into the meta-analysis because it did not provide information on standard deviations for serum trace elements levels [42] and the other was the only study describing plasma selenium levels in PCOS and control women [44].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Blood Trace Element Concentrations in Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Spritzer

Lecke

Fabris

et al. 2016

Biol Trace Elem Res

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Polycystic ovary syndrome (PCOS) is a prevalent condition in women of reproductive age. PCOS is characterized by androgen excess and chronic anovulation and associated with low-grade inflammation and metabolic comorbidities. Some trace elements have been linked to pathophysiological mechanisms of oxidative stress and inflammation in different disorders. Therefore, we conducted a systematic review and meta-analysis of the available evidence regarding trace element concentrations in PCOS. We reviewed MEDLINE and EMBASE in search of case-control, cross-sectional, and cohort studies published until September 2015. Of 183 studies identified, six were selected for systematic review. All used the Rotterdam criteria for the diagnosis of PCOS. Two studies evaluating chromium and one assessing cobalt levels did not observe differences between PCOS and controls. Another study recorded similar nickel and vanadium levels between the groups, but lower selenium concentrations in women with PCOS compared to controls. Four studies were included in the random effects model meta-analysis, for a total of 264 PCOS and 151 control women. Copper levels were found to be higher in women with PCOS than in controls [mean difference 0.12 ppm (95 % CI 0.07; 0.17 ppm); I 2 = 0 %]. Manganese [mean difference 0.04 ppm (95 % CI −0.05; 0.13 ppm); I 2 = 94.4 %] and zinc concentrations [mean difference 0.02 ppm (95 % CI −0.12; 0.16 ppm); I 2 = 92.4 %] were similar between the groups. The present results suggest a relationship between increased copper concentration and PCOS. This systematic review and meta-analysis is registered in PROSPERO under number CRD42016034036.

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Section: Discussionmentioning

confidence: 99%

“…One single study evaluating plasma selenium in PCOS reported lower levels in the PCOS group in comparison with controls [44] (Fig. 2).…”

Section: Seleniummentioning

confidence: 97%

Section: Study Selectionmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Blood Trace Element Concentrations in Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Spritzer

Lecke

Fabris

et al. 2016

Biol Trace Elem Res

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“…As this study is among the first that reports the effect of selenium supplementation on hormonal profiles among women with PCOS, we did not compare findings of the current study with others although few studies assessed the association between selenium levels and hormonal profiles in women with PCOS. For instance, Coskun et al [44] reported decreased plasma concentrations of selenium and a negative association between selenium and LH, total testosterone (tT) in PCOS women, indicating that selenium may play a role in the pathogenesis of PCOS related with hyper- androgenism. Selenium supplementation may result in decreased serum DHEA levels and hirsutism through improved markers of insulin metabolism [13] and decreased oxidative stress [12].…”

mentioning

confidence: 99%

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

et al. 2015

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Selenium supplementation could be effective on reproductive outcomes, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). The aim of the study was to determine the effects of selenium supplementation on reproductive outcomes, biomarkers of inflammation, and oxidative stress in PCOS patients. The present randomized double-blind, placebo-controlled trial was conducted on 64 women aged 18?40 years old with PCOS at the clinic affiliated to Ardabil University of Medical Sciences, Ardabil, Iran. The participants were randomly assigned to 2 groups receiving either 200??g selenium daily (n=32) or placebo (n=32) for 8 weeks. Hormonal profiles, biomarkers of inflammation, and oxidative stress were measured and compared both before and after the treatment. After 8 weeks of intervention, pregnancy rate in the selenium group was higher than in the placebo group: 18.8 (6/32) vs. 3.1% (1/32), p=0.04. In addition, alopecia (40.6 vs. 9.4%, p=0.004) and acne (46.9 vs. 12.5 %, p=0.003) decreased following the consumption of selenium supplements compared with placebo. Additionally, patients who received selenium supplements had significantly decreased serum dehydroepiandrosterone (DHEA) levels (p=0.02), hirsutism (modified Ferriman?Gallwey scores) (p<0.001), serum high sensitivity C-reactive protein (hs-CRP) (p=0.02), and plasma malondialdehyde (MDA) levels (p=0.01) compared with placebo. We did not observe any significant effects of taking selenium supplements on other hormonal profiles, nitric oxide (NO), and other biomarkers of oxidative stress. Taken together, selenium supplementation for 8 weeks among PCOS women had beneficial effects on reproductive outcomes, DHEA, hs-CRP, and MDA levels.

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