Plasma Selenium Levels in First Trimester Pregnant Women with Hyperthyroidism and the Relationship with Thyroid Hormone Status

Arıkan, Tuğba Atılan

doi:10.1007/s12011-015-0310-y

Cited by 9 publications

(7 citation statements)

References 40 publications

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“…Data from a study conducted in China with 6152 participants demonstrated that the risk of both hypothyroidism and hyperthyroidism is greatest in non-pregnant individuals from the bottom quintile for blood selenium status (Wu et al 2015). A study from turkey demonstrated that plasma selenium concentrations in the first trimester of pregnancy were lower in women with hyperthyroidism compared to healthy pregnant women (Arikan, 2015). Importantly, these women had elevated T 3 and T 4 , a phenotype similar to that presented in the present study.…”

Section: Discussionsupporting

confidence: 80%

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Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth

Hofstee

Bartho

McKeating

et al. 2019

The Journal of Physiology

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Key points Inappropriate intake of key micronutrients in pregnancy is known to alter maternal endocrine status, impair placental development and induce fetal growth restriction. Selenium is an essential micronutrient required for the function of approximately 25 important proteins. However, the specific effects of selenium deficiency during pregnancy on maternal, placental and fetal outcomes are poorly understood. The present study demonstrates that maternal selenium deficiency increases maternal triiodothyronine and tetraiodothyronine concentrations, reduces fetal blood glucose concentrations, and induces fetal growth restriction. Placental expression of key selenium‐dependent thyroid hormone converting enzymes were reduced, whereas the expression of key placental nutrient transporters was dysregulated. Selenium deficiency had minimal impact on selenium‐dependent anti‐oxidants but increased placental copper concentrations and expression of superoxide dismutase 1. These results highlight the idea that selenium deficiency during pregnancy may contribute to thyroid dysfunction, causing reduced fetal growth, that may precede programmed disease outcomes in offspring. Abstract Selenium is a trace element fundamental to diverse homeostatic processes, including anti‐oxidant regulation and thyroid hormone metabolism. Selenium deficiency in pregnancy is common and increases the risk of pregnancy complications including fetal growth restriction. Although altered placental formation may contribute to these poor outcomes, the mechanism by which selenium deficiency contributes to complications in pregnancy is poorly understood. Female C57BL/6 mice were randomly allocated to control (>190 µg kg–1, n = 8) or low selenium (<50 µg kg–1, n = 8) diets 4 weeks prior to mating and throughout gestation. Pregnant mice were killed at embryonic day 18.5 followed by collection of maternal and fetal tissue. Maternal and fetal plasma thyroid hormone concentrations were analysed, as was placental expression of key selenoproteins involved in thyroid metabolism and anti‐oxidant defences. Selenium deficiency increased plasma tetraiodothyronine and triiodothyronine concentrations. This was associated with a reduction in placental expression of key selenodependent deiodinases, DIO2 and DIO3. Placental expression of selenium‐dependent anti‐oxidants was unaffected by selenium deficiency. Selenium deficiency reduced fetal glucose concentrations, leading to reduced fetal weight. Placental glycogen content was increased within the placenta, as was Slc2a3 mRNA expression. This is the first study to demonstrate that selenium deficiency may reduce fetal weight through increased maternal thyroid hormone concentrations, impaired placental thyroid hormone metabolism and dysregulated placental nutrient transporter expression. The study suggests that the magnitude of selenium deficiency commonly reported in pregnant women may be sufficient to impair thyroid metabolism but not placental anti‐oxidant concentrations.

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Section: Discussionsupporting

confidence: 80%

“…). A study from turkey demonstrated that plasma selenium concentrations in the first trimester of pregnancy were lower in women with hyperthyroidism compared to healthy pregnant women (Arikan, ). Importantly, these women had elevated T 3 and T 4 , a phenotype similar to that presented in the present study.…”

Section: Discussionmentioning

confidence: 99%

Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth

Hofstee

Bartho

McKeating

et al. 2019

The Journal of Physiology

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“…Several studies have evaluated the correlation between Se status and thyroid outcomes in pregnancy, with the majority of them suggesting better Se status is linked with better thyroid function [ 24 , 90 , 91 , 92 , 93 ]. Table 2 summarizes the details of studies that evaluate Se status and thyroid outcomes in pregnant women.…”

Section: Selenium Status Thyroid and Pregnancymentioning

confidence: 99%

Selenium Supplementation in Pregnant Women with Autoimmune Thyroiditis: A Practical Approach

et al. 2022

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Selenium (Se) is an essential trace element with antioxidant and anti-inflammatory properties and a pivotal role in thyroid metabolism. Ensuring a sufficient Se supply is possible via a balanced, wholesome diet; however, Se content in foods may be different throughout geographical areas. Se supplementation is expected to improve inflammatory status in patients with autoimmune thyroiditis, especially in those with high activity, and has been demonstrated as effective in reducing the thyroid peroxidase antibodies titer. Se status seems to affect thyroid function in pregnancy, which prompts the potential role of Se supplementation in such patients. Few clinical trials have investigated the effectiveness of Se supplementation in pregnant women with thyroiditis, and their results suggest the safety and effectiveness of this element in reducing autoantibody levels and preventing postpartum thyroiditis development, although limited. Hence, more robust evidence is needed to confirm these data. The current study aims to summarize published data on the relationship between Se and thyroid status in pregnant women with thyroiditis and the potential use of Se. Moreover, an algorithm for Se supplementation is proposed for pregnant women with thyroiditis to help endocrinologists in daily clinical practice to consider Se status.

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“…Other studies also used samples from erythrocytes and semen to assess Se concentrations [44,45]. Overall, values were widely variable ranging from 50–138 μg/l in healthy populations [43,44,45,46,47,48,49,50,51,52,53,54,55].…”

Section: Regional Variability Of Se Status: a Focus On The Situatimentioning

confidence: 99%

Selenium and Health: An Update on the Situation in the Middle East and North Africa

2019

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Selenium (Se) is an important trace element that should be present in the diet of all age groups to provide an adequate intake. Se is incorporated in 25 known selenoproteins, which mediate the biological effects of Se including, immune response regulation, maintenance of thyroid function, antioxidant defense, and anti-inflammatory actions. A balanced intake of Se is critical to achieve health benefits because depending on its status, Se has been found to play physiological roles or contribute to the pathophysiology of various diseases including, neurodegenerative diseases, diabetes, cancer, and cardiovascular disorders. Se status and intake are very important to be known for a specific population as the levels of Se are highly variable among different populations and regions. In the Middle East and North African (MENA) region, very little is known about the status of Se. Studies available show that Se status is widely variable with some countries being deficient, some over sufficient, and some sufficient. This variability was apparent even within the same country between regions. In this review, we summarized the key roles of Se in health and disease and discussed the available data on Se status and intake among countries of the MENA region.

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Plasma Selenium Levels in First Trimester Pregnant Women with Hyperthyroidism and the Relationship with Thyroid Hormone Status

Cited by 9 publications

References 40 publications

Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth

Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth

Selenium Supplementation in Pregnant Women with Autoimmune Thyroiditis: A Practical Approach

Selenium and Health: An Update on the Situation in the Middle East and North Africa

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