Plasma <scp>miR</scp>‐409‐3p promotes acute cerebral infarction via suppressing <scp>CTRP3</scp>

Song, Xiandong; Li, Shixing; Zhu, Min

doi:10.1002/kjm2.12327

Cited by 13 publications

(4 citation statements)

References 31 publications

(59 reference statements)

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“…At present, some microRNAs (miRNAs) have been shown to be involved in ACI pathological processes. [8,9] Additionally, a study by Xiang et al [10] has analyzed the miRNAs with significantly changed expression levels after thrombolytic treatment in patients with ACI, and this study results reveal that miR-106a-5p is significantly downregulated after thrombolysis compared with before thrombolysis. Notably, miR-106a-5p is an atherosclerosis associated miRNA that has been shown to regulate vascularization, endothelial cell and smooth muscle cell activity.…”

Section: Introductionmentioning

confidence: 99%

CT perfusion imaging parameters and serum miR-106a-5p predict short- and long-term prognosis in acute cerebral infarction patients after intravenous thrombolysis

Guo

2023

Medicine

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Background: Some microRNAs have been found to be abnormal in patients with acute cerebral infarction (ACI) after intravenous thrombolysis. This study aimed to measure the expression of miR-106a-5p in ACI patients before and after thrombolytic treatment, and to investigate the prognostic value of miR-106a-5p and computed tomography perfusion imaging (CTPI) parameters in ACI patients receiving thrombolysis. Methods: The levels of serum miR-106a-5p were detected by quantitative real-time PCR in 78 ACI patients before thrombolysis, 24 hours after thrombolysis, and 3 months (90 days) after onset. The correlation of miR-106a-5p with continuous variables were analyzed using Pearson correlation analysis. The association of miR-106a-5p and CTPI parameters with prognosis of patients receiving thrombolysis was evaluated by logistic regression analysis. The accuracy and thresholds of miR-106a-5p and CTPI parameters for discriminating patients with unfavorable prognosis after thrombolysis were assessed by receiver operating characteristic analysis. Results: Serum miR-106a-5p expression was decreased in ACI patient after thrombolysis. Then, significant correlations of miR-106a-5p with National Institutes of Health Stroke Scale and CTPI parameters were found. Moreover, miR-106a-5p, cerebral blood flow (CBF) and cerebral blood volume (CBV), which are 2 CTPI parameters, were independently correlated with short- and long-term prognosis after thrombolysis. Furthermore, miR-106a-5p, CBF and CBV revealed good accuracy in predicting the prognosis of patients after thrombolysis, and their combination showed the best accuracy. Conclusion: Thrombolysis downregulates miR-106a-5p in ACI patients, and miR-106a-5p, CBF and CBV have considerable potentials to predict short- and long-term prognosis in ACI patients receiving intravenous thrombolysis.

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Section: Introductionmentioning

confidence: 99%

CT perfusion imaging parameters and serum miR-106a-5p predict short- and long-term prognosis in acute cerebral infarction patients after intravenous thrombolysis

Guo

2023

Medicine

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“…8 Additionally, an increased level of miR-409-3p in plasma was correlated with disease severity, making it efficient for the early diagnosis of AIS. 10 Rainer et al also revealed that plasma miR-124-3p and miR-16 could be useful molecular markers for the early prediction of mortality and poststroke modified Rankin Score. 11 The present study investigated two GEO (Gene Expression Omnibus) datasets (GSE110993 and GSE86291) to identify plasma miRNAs that were differentially expressed between AIS and health controls.…”

Section: Introductionmentioning

confidence: 99%

“…For example, a study by Eyileten et al found that patients with AIS had significantly higher miR‐19a‐3p and lower let‐7f levels in plasma compared to control patients, with an area under the receiver operating characteristic (ROC) curve of 0.755 for miR‐19a‐3p and 0.874 for let‐7f 8 . Additionally, an increased level of miR‐409‐3p in plasma was correlated with disease severity, making it efficient for the early diagnosis of AIS 10 . Rainer et al also revealed that plasma miR‐124‐3p and miR‐16 could be useful molecular markers for the early prediction of mortality and poststroke modified Rankin Score 11 …”

Section: Introductionmentioning

confidence: 99%

The expression levels of circulating miR‐140‐3p, miR‐130a‐3p, and miR‐320b as diagnostic biomarkers in acute ischemic stroke

Ju,

Tang,

et al. 2023

The Kaohsiung J of Med Scie

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Plasma miRNAs can characterize several diseases, including acute ischemic stroke (AIS), which is noninvasive and currently affordable in most laboratories worldwide. We aimed to demonstrate plasma miR‐140‐3p, miR‐130a‐3p, and miR‐320b as diagnostic biomarkers in AIS.GSE110993 and GSE86291 datasets were analyzed to obtain plasma differentially expressed miRNAs between AIS and healthy control subjects (HCs). We further applied RT‐qPCR for the validation in 85 AIS patients and 85 HCs. Receiver operating characteristic (ROC) curve were conducted to evaluate their diagnostic utility in AIS. Correlation was analyzed between DEmiRNAs and clinical and laboratory parameters, as well as inflammatory markers. The plasma levels of miR‐140‐3p, miR‐130a‐3p, and miR‐320b were found to be consistently altered in both GSE110993 and GSE86291 datasets. In comparison to HCs, AIS patients at admission exhibited lower levels of miR‐140‐3p and miR‐320b and higher level of miR‐130a‐3p in their plasma. The ROC analysis revealed that plasma miR‐140‐3p, miR‐130a‐3p, and miR‐320b had area under the curve values of 0.790, 0.831, and 0.907, respectively. When combined, these miRNAs showed superior discriminatory power with a sensitivity of 91.76% and specificity of 95.29%. Plasma miR‐140‐3p and miR‐320b negatively correlated glucose levels and inflammatory markers (IL‐6, MMP‐2, MMP‐9, and VEGF) in AIS patients. Conversely, plasma miR‐130a‐3p levels were positively associated with glucose levels and these markers. Plasma miR‐140‐3p, miR‐130a‐3p, and miR‐320b levels varied significantly among AIS patients with different NIHSS scores. Plasma miR‐140‐3p, miR‐130a‐3p, and miR‐320b had high diagnostic value in AIS patients, which were correlated with inflammation and severity in stroke.

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“…miRNA plays an important role in the pathophysiological regulation of cardiovascular diseases and is associated with cerebral ischemia-reperfusion injury and neuronal apoptosis [6,7]. Recently, some brain-specific miRNAs have been identified, and the differential serum levels may be promising indicators for the occurrence and prognosis of ACI, such as miR-409-3p, miR-210, and miR-137 [8,9]. miR-138-5p has been reported to be a protective factor and is involved in a variety of cell damage mechanisms under hypoxia, such as myocardial cell and retinal endothelial cell [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Dysregulation of Serum miR-138-5p and Its Clinical Significance in Patients with Acute Cerebral Infarction

Mao¹,

Luan²,

Qi³

2022

Cerebrovasc Dis

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Introduction: Acute cerebral infarction (ACI) occurs with the involvement of differential expression of microRNAs. The study detected the expression pattern of miR-138-5p in the serum of ACI cases and evaluated its clinical significance, in an attempt to provide some guidance for the treatment and daily nursing of patients with ACI clinically. Methods: Levels of miR-138-5p in the serum of ACI patients and healthy controls (HCs) were detected via qRT-PCR. Ninety days after treatment, the modified Rankin Scale (mRS) was used to evaluate the prognosis of ACI patients. Receiver operating characteristic (ROC) curve was drawn, and the area under the curve was calculated. The logistic regression analysis was performed to estimate the relationship between various indicators and the clinical outcome. Results: miR-138-5p showed a diminished trend in ACI cases compared with the control group. A significantly negative correlation was detected for serum miR-138-5p with the National Institutes of Health Stroke Scale score in all ACI cases (r = −0.704, p < 0.001). The ROC curve demonstrated the diagnostic potential of serum miR-138-5p to distinguish ACI from HCs. Lessened expression of miR-138-5p was detected in ACI patients with poor prognosis, which can predict the poor prognosis of ACI patients after treatment. Logistic regression analysis determined the independent influence relationship between miR-138-5p and poor prognosis. Conclusion: Diminished miR-138-5p is identified to be a risk factor for the occurrence of ACI, and it is associated with the worse outcome of the patients.

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Plasma miR‐409‐3p promotes acute cerebral infarction via suppressing CTRP3

Cited by 13 publications

References 31 publications

CT perfusion imaging parameters and serum miR-106a-5p predict short- and long-term prognosis in acute cerebral infarction patients after intravenous thrombolysis

CT perfusion imaging parameters and serum miR-106a-5p predict short- and long-term prognosis in acute cerebral infarction patients after intravenous thrombolysis

The expression levels of circulating miR‐140‐3p, miR‐130a‐3p, and miR‐320b as diagnostic biomarkers in acute ischemic stroke

Dysregulation of Serum miR-138-5p and Its Clinical Significance in Patients with Acute Cerebral Infarction

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