Plasma‐saliva ratio of theophylline following oral theophylline derivatives [proceedings]

Boobis, Susan; Trembath, Peter W.

doi:10.1111/j.1365-2125.1978.tb04627.x

Cited by 13 publications

(2 citation statements)

References 3 publications

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“…c) The correlation between serum and saliva theophylline concentrations is not fully described by a linear equation (2). The variation observed is of the same order or less than previously found by several authors (2,3,7) and rather more than that shown by others (6,9,11). This variation in serum/saliva concentration ratio indicates that, even after having established the plasma/saliva ratio for an individual patient, the use of saliva theophylline measurements alone is unreliable for the routine monitoring of theophylline treatment.…”

Section: Figsupporting

confidence: 81%

Theophylline Concentrations in Serum and Saliva after Oral Microcrystalline and Sustained‐Release Preparations in Asthmatics

Munch

Sösndergaard

Weeke

1981

Allergy

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Theophylline concentrations in saliva have been compared with those in serum in 13 asthmatic patients after single and multiple oral dosage of a microcrystalline theophylline tablet (Nuelin) and a sustained-release preparation (Nuelin Retard). There was wide individual variation in the ratio of serum to saliva concentrations indicating that, even when individual serum to saliva ratios have been established, the use of saliva theophylline measurements alone is unreliable for the routine monitoring of theophylline therapy. Both preparations produced mean serum theophylline concentrations within the 10--20 mcg/ml range, the sustained-release tablet giving higher monitoring through values and smaller through to peak variation. The preparations were equally and highly bioavailable. Side effects were reported by three patients, which were the patients with the highest AUC. The Nuelin Retard preparation appears to provide smooth, sustained serum theophylline concentrations within the therapeutic range and the simple, twice-daily dosage should result in improved patient compliance.

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Section: Figsupporting

confidence: 81%

Theophylline Concentrations in Serum and Saliva after Oral Microcrystalline and Sustained‐Release Preparations in Asthmatics

Munch

Sösndergaard

Weeke

1981

Allergy

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“…Monitoring of serum theophylline levels is well established because of the narrow range of optimal serum concentration and the great interindividual differences in pharmacokinetics especially in ~h i l d r e n .~.~ Knowledge of theophylline levels is also useful in assessing and improving patient ~o m p l i a n c e .~ In order to make theophylline drug monitoring more convenient for the patient, numerous investigators have studied the accuracy of salivary theophylline levels in predicting serum levels and have obtained conflicting results . [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] In this study we have investigated the accuracy and predictive value of saliva theophylline measurements using fluorescence polarization immunoassay (FPIA), which has been proven to be a reliable The Seralyzer (reagent strip reflectance photometer method), which can be used for rapid theophylline determination in an ambulatory setting,21,22 was simultaneously tested. We tried to make sampling of saliva easier by using a special device.…”

Section: Introductionmentioning

confidence: 99%

Monitoring theophylline levels in serum and saliva using fluorescence polarization immunoassay and seralyzer

Schulte¹,

W²,

Schmidt³

et al. 1989

Pediatric Pulmonology

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The reliability and predictive value of salivary theophylline levels was investigated in 58 children who were treated with oral sustained-release theophylline preparations for bronchial asthma. Serum and saliva levels were assessed by fluorescence polarization immunoassay (FPIA), and Seralyzer (reagent strip reflectance photometer method). Forty-six paired serum and saliva samples from 28 patients (Group 1) were used to develop a linear regression formula. This formula was tested on 130 paired serum and saliva samples from 32 patients (Group 2). When saliva theophylline levels were assayed using FPIA, 95% of serum levels were predicted within 30% of the measured value. Using Seralyzer, 95% of serum levels were predicted within 45% of the measured value. For patients with three and more paired serum and saliva specimens, individual regression formulas were determined showing considerable variation. This study indicates that salivary theophylline levels provide for an estimation of serum levels if FPIA is used. The Seralyzer technique is only useful for serum theophylline measurements. Using a special device it is now easier to obtain saliva samples than by conventional methods.

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Serum/Saliva Correlations for Theophylline in Asthmatics

Blanchard¹,

Harvey²,

Morgan³

1991

The Journal of Clinical Pharma

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Theophylline levels in mixed saliva (both stimulated and unstimulated) were compared with total and free (unbound) serum theophylline levels in 28 asthmatic outpatients using theophylline regularly. Stimulated saliva predicted both total and unbound serum theophylline concentrations within +/- 1 microgram/mL in 62.5% and 92.9%, respectively, of the samples examined. In addition, the total serum levels could be used to predict unbound serum concentrations to within +/- 1 mg/L in 100% of the cases that were examined. These results indicate that saliva levels predict the unbound serum theophylline levels with greater accuracy and precision than they predict total serum theophylline levels. In addition, total serum levels can be used to reliably predict unbound serum levels. The use of mixed stimulated saliva is recommended as a reliable non-invasive method for monitoring unbound serum theophylline levels. The therapeutic range for saliva, which corresponds to the accepted total serum concentration range of 10-20 mg/L, is approximately 5.6-11.3 mg/L.

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Plasma‐saliva ratio of theophylline following oral theophylline derivatives [proceedings]

Abstract: . The changes in antipyrine metabolism and urinary ratios of corticosteroid metabolites indicate hepatic enzyme induction which could account for the enhanced elimination of DL473 on repeated dosage.

Cited by 13 publications

References 3 publications

Theophylline Concentrations in Serum and Saliva after Oral Microcrystalline and Sustained‐Release Preparations in Asthmatics

Theophylline Concentrations in Serum and Saliva after Oral Microcrystalline and Sustained‐Release Preparations in Asthmatics

Monitoring theophylline levels in serum and saliva using fluorescence polarization immunoassay and seralyzer

Serum/Saliva Correlations for Theophylline in Asthmatics

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