Plasma ropivacaine concentrations after ultrasound-guided transversus abdominis plane block for open retropubic prostatectomy

Abstract

Ropivacaine concentration did not alter pharmacokinetic profile following TAP blocks.

A comparison of plasma levobupivacaine concentrations following transversus abdominis plane block and rectus sheath block

“…In the rectus sheath group, a gradual elevation in plasma levobupivacaine concentration was seen, and the time to peak concentration (Tmax) was more than double that in the TAP group. Previous studies on the rise in plasma ropivacaine concentration reported that Tmax was 23.1 min and 48.5 min after TAP block and rectus sheath block , respectively. Similarly, another study reported that Tmax of ropivacaine was 35 min and 53 min after TAP and rectus sheath block, respectively.…”

“…Kitayama et al proposed two possible explanations for the different changes in plasma concentrations of local anaesthetics after TAP and rectus sheath blocks. One of the explanations is that in a TAP block, local anaesthetics are readily absorbed into the blood stream because they are injected into the neurovascular plane between the internal oblique and transversus abdominis muscles.…”

Systematic review of the systemic concentrations of local anaesthetic after transversus abdominis plane block and rectus sheath block

“…Of these instances, three patients exhibited subjective symptoms of mild LA systemic toxicity. 21 Symptoms were limited to perioral and tongue paraesthesia, a metallic taste, and slurred speech. No instances of severe neurotoxicity (seizures) or persistent cardiovascular instability were observed.…”

“…Eleven studies measured systemic concentrations of LA agents after bilateral USG TAPB (Table 2). Abdominal or pelvic surgery was performed in eight studies, [18][19][20][21][22][23][24][25] while in the remaining three studies participants were healthy volunteers who did not undergo any surgery. [26][27][28] Eight of the 11 studies used ropivacaine.…”

Update on the clinical utility and practical use of ropivacaine in Chinese patients

“…The early absorption speed of ropivacaine can be affected by ropivacaine-induced vasoconstriction. However, a study examining the effects of various ropivacaine concentrations (0.25%, 0.5%, and 0.75%) on pharmacokinetic profiles following transversus abdominal plane did not find any difference among the concentrations 19. The mean half-time of the rapid absorption is approximately 14 minutes, while the mean absorption half-time of the slower phase is approximately 4.2 hours 20.…”