Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: Case Reports

Abstract

Platelet-rich fibrin (PRF) is an autologous blood concentrate obtained without anticoagulants by centrifugation of patients’ peripheral venous blood. PRF is considered to enhance the formation of new bone. The aim of this manuscript was to present two case reports of permanent teeth with closed apexes with periapical lesions, treated endodontically with the use of PRF. The root canals were mechanically cleaned and shaped with NiTi files and irrigated with 5.25% sodium hypochlorite (NaOCl), 40% citric acid (CA), and triple distillated water. Before the canal systems were obturated, A-PRF was used as a scaffold and was placed below the cementodentinal junction with hand pluggers. Cone beam computerized tomography (CBCT) was used to assess the resolutions of periapical radiolucencies. After 6 months, the measurements of both periapical lesions were significantly reduced. Although the performed root canal treatments (RCTs) can definitely be recognized as successful, it must be emphasized that mechanical shaping and cleaning of the root canals with special disinfecting solutions significantly affect the clinical efficacy of RCT. It seems impossible to state that PRF played a leading role in the healing process of the presented periapical lesions. Further studies must be performed to assess whether RCT of mature teeth with an additional PRF application is superior to RCT performed alone.

Endodontic Surgical Treatment: Lateral Window Approach and Use Prf. Case Report

“…PRF represents a new step in the therapeutic collaboration of platelet gel. Autologous platelet concentrates are widely used in regenerative dental endodontics [27][28][29][30][31][32] .…”

“…Three main types of biological scaffolds present applied: blood clot revascularization (BCR), plateletrich plasma (PRP) and platelet-rich fibrin (PRF) 5,6 .…”

Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: A Narrative Review

“…The clinical effects of conventional RCT with an additional supplementation of PRF in the treatment of permanent teeth with closed apexes, diagnosed with periapical lesions, have been examined only by Machut et al [128]. The authors presented two case reports with satisfactory bone healing 6 months after the end of RCT.…”

“…Table 3 presents the use of PRF in the endodontic treatment of permanent teeth with closed apexes on the basis of the literature [128][129][130][131][132][133][134][135][136][137][138][139][140][141]. AC-anticoagulant, BG-bioactive glass, β-TCP-β-tricalcium phosphate, CGF-concentrated growth factor, EDTA-Ethylene diamine tetraacetic acid, FDBA-freeze-dried bone allograft, HA-hydroxyapatite, MTA-Mineral Trioxide Aggregate, n/a-not applicable, PPP-platet poor plasma, RCT-root canal treatment, TCP-tricalcium phosphate.…”

“…PRF in the endodontic treatment of permanent teeth with closed apexes on the basis of the literature[128][129][130][131][132][133][134][135][136][137][138][139][140][141].…”