Plasma Renin, Renin Substrate, Angiotensin Ii, and Aldosterone in Hypertensive Disease of Pregnancy

Weir, R. J.; Fraser, Robert; Lever, A. F.; Morton, J. J.; Brown, J. J.; Kraszewski, A.; McIlwaine, Gillian; Robertson, J. I. S.

doi:10.1016/s0140-6736(73)91540-7

Cited by 159 publications

(62 citation statements)

References 23 publications

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“…In the present study, AngII levels full slightly in preeclampsia. There are conflicting results whether peripheral level of AngII in preeclampsia is significantly increased (Symonds et al 1975 ;Symonds and Broughton Pipkin 1978), decreased (Weir et al 1973 ;Pedersen et al 1982), or unchanged (Massani et al 1967 ;Gordon et al 1973). Thus, the role of AngII in causing the raised blood pressure in preeclampsia is uncertain.…”

Section: Discussionmentioning

confidence: 99%

Plasma renin activity, angiotensin II, prostacyclin and thromboxane A2 concentrations in 139 preeclamptic patients.

Furuhashi¹,

Tsujiei²,

Kimura³

et al. 1990

Tohoku J. Exp. Med.

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Plasma renin activity , plasma concentratrions of angiotensin 11(AngII), stable metabolites (6-keto-prostaglandin Fla : 6-keto-PGFIa) of prostacyclin (PGI2) and a metabolite (thromboxane B2: TXB2) of thromboxane A2 (TXA2 ) were measured with radioimmunoassay(RIA) in 107 normal pregnancy (control) and 139 preeclamptic patients in 28-41 gestational weeks. PRA and 6-ketoPGFIa were significantly higher and AngII was slightly higher in preeclampsia than in control, and TXB2 was significantly lower in preeclampsia in control. The ratio of 6-keto-PGFIa/TXB2 was significantly lower in preeclampsia than in control. These data suggest that the changes in the renin-angiotensin system may not be primary alterations in preeclampsia. It can be speculated that in preeclampsia the changes in absolute concentrations of 6-keto-PGFIa and TXB2 are less important than the decrease in the ratio of the 6-keto-PGFIa/TXB2. plasma renin activity ; angiotensin II ; prostacyclin ; tromboxane A2; preeclampsia The renin-angiotensin system is known to play an important role in the maintenance of normal blood pressure and it has been shown that women who have, or are destined to develop, preeclampsia show an increased sensitivity to infused angiotensin II (Gant et al. 1976). This effect can be abolished by the administration of prostaglandin E2 or induced by the prior administration of an inhibitor of prostaglandin synthetase (Everetta et al. 1978). It is well established that vasocon-striction in the arteriolar bed, particularly in the uterus and kidney, is a characteristic feature of preeclampsia. Thromboxane A2 (TXA2) and prostacyclin (PGI2) are potent vasoactive compounds. TXA2 causes vasoconstriction and induces platelet aggregation, whereas PGI2 has the opposite properties (Moncada and Vane 1978). Other studies with isolated tissues have shown that there

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Section: Discussionmentioning

confidence: 99%

Plasma renin activity, angiotensin II, prostacyclin and thromboxane A2 concentrations in 139 preeclamptic patients.

Furuhashi¹,

Tsujiei²,

Kimura³

et al. 1990

Tohoku J. Exp. Med.

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“…Thus, sodium balance could modify measured A-II levels and the relationship of these levels to blood pressure. Attempts to resolve existing conflicts in observations made by WEIR et al [14] and SYMOND et al [11] in regard to plasma A-II and blood pressure, should be done with strict attention to the state of sodium balance.…”

Section: Discussionmentioning

confidence: 92%

“…However, these clinical observations have led many obstetricians/gynecologists, hoping to prevent or minimize symptoms of the disease, to advise patients to alter normal patterns of dietary sodium intake. Yet, GANT et al [14], have shown an increased responsiveness to A-II in subjects destined to develop PIH long before clinical evidence of the disease is apparent.…”

Section: Discussionmentioning

confidence: 99%

“…Plasma levels of A-II are elevated in normal pregnancy, but reported levels of PIH are in conflict. WEIR et al [14], found A-II levels significantly lower in hypertensive gravidas when compared to controls of similar gestation. However, SYMOND et al [11], found a positive correlation between levels of plasma A-II and diastolic blood pressure in women with PIH.…”

Section: Introductionmentioning

confidence: 93%

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Plasma angiotensin II and blood pressure changes during dietary sodium manipulation

Lee¹,

Sokol²,

Todd³

1984

Journal of Perinatal Medicine

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“…However, reports of excessive Na + The initial fall in BP occurs at the same time as a retention, 9 which is not due to the renin-angiotensin reduction in vascular sensitivity to vasoconstrictors II system since this system is suppressed in presuch as angiotensin II. 3 Increased production of eclampsia, 10 as well as increased red cell membrane vasodilator prostaglandins from the endothelium of permeability to Na + , 11 suggest that abnormal cell the vessel wall 4 or, as recently suggested, reduced sodium homeostasis may be involved. circulating levels of inhibitors of the L-arginineIntracellular (Na + ) and pH, both of which may nitric oxide pathway, 5 may be responsible for the influence smooth muscle contractility, renal Na + decreased vascular tone.…”

Section: Introductionmentioning

confidence: 92%

Platelet sodium/hydrogen ion exchange in normal pregnancy and non-proteinuric pre-eclampsia

et al. 1997

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In non-pregnant individuals, abnormalities in cation pmolNa + /10 6 cells/min respectively; the third trimester values were higher (P Ͻ 0.05) than those in the first and transport in vascular tissues have been linked to essential hypertension. In the present study, we consider second trimester and were also higher than those of non-pregnant women (415 ± 20). Vmax of patients with whether Na + /H + exchange (NHE) is affected in non-proteinuric pre-eclampsia (NPP). Platelet NHE character-NPP in the third trimester (712 ± 44) was not different from gestational age-matched controls. Km values were istics and plasma cholesterol were measured in a crosssectional study of normal primigravidae at 14 ± 0.5 (n = not affected by gestational age or NPP. Plasma cholesterol concentration was positively correlated with Vmax 9), 29 ± 0.7 (n = 7), 39 ± 0.4 (n = 8) weeks gestation, in women with NPP (n = 15) and in non-pregnant women values during normotensive pregnancy (r = 0.493, P Ͻ 0.05). (n = 8). Amiloride-sensitive 22 Na uptake was measured in platelets which had been acid loaded, to stimulateIn conclusion, the capacity for amiloride-sensitive Na + uptake by platelets correlates positively with gestational NHE, by suspension in isotonic potassium propionate buffer (pH 6.7). Intraplatelet radioactivity was used to age during normal pregnancy. However, neither the capacity nor affinity for Na + was altered in NPP platelets calculate the affinity (Km) and the capacity (Vmax) of Na + uptake. In normotensive women, Vmax (mean ± s.e.)suggesting that NHE is not implicated in the pathophysiology of this condition. at 14, 29, 39 weeks gestation and 6 weeks postpartum were 452 ± 46, 469 ± 33, 713 ± 101 and 562 ± 77 Keywords: Na + /H + exchange; platelets; pre-eclampsia; cholesterol proteinuric pre-eclampsia (NPP) and proteinuric Introduction pre-eclampsia (PPE). 6 Hepatic dysfunction, platelet During normal pregnancy, despite increased cardiac activation, coagulation changes and abnormal vasoutput, expanded plasma volume and elevated circular endothelial function may occur when the disculating levels of renin, angiotensin II and aldosease progresses to the more severe form. 7,8 terone, 1 there is an initial fall in systemic bloodThe mechanisms underlying the vascular hyperpressure (BP) in the first trimester with a slow prosensitivity during pre-eclampsia are not clearly gressive rise to non-pregnant values towards term. 2 understood. However, reports of excessive Na + The initial fall in BP occurs at the same time as a retention, 9 which is not due to the renin-angiotensin reduction in vascular sensitivity to vasoconstrictors II system since this system is suppressed in presuch as angiotensin II. 3 Increased production of eclampsia, 10 as well as increased red cell membrane vasodilator prostaglandins from the endothelium of permeability to Na + , 11 suggest that abnormal cell the vessel wall 4 or, as recently suggested, reduced sodium homeostasis may be involved. circulating levels of inhibitors of the L-arginineIntracellular (Na ...

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Plasma Renin, Renin Substrate, Angiotensin Ii, and Aldosterone in Hypertensive Disease of Pregnancy

Cited by 159 publications

References 23 publications

Plasma renin activity, angiotensin II, prostacyclin and thromboxane A2 concentrations in 139 preeclamptic patients.

Plasma renin activity, angiotensin II, prostacyclin and thromboxane A2 concentrations in 139 preeclamptic patients.

Plasma angiotensin II and blood pressure changes during dietary sodium manipulation

Platelet sodium/hydrogen ion exchange in normal pregnancy and non-proteinuric pre-eclampsia

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