Plasma renin activity (PRA), cryorenin (CR) and total renin (TR) in normotensive children (NTC)

Abstract

Hungary . E ff e c t s o f a nd r o ge n overproduct ion on s ki n tar g e t o rg an s in chi ld re n w i th c ong e n it al a d ren al h y p e rp la sia . T wo f e mal e si b s aged 2 , r e sp . 3 y ear s we re studi ed wi t h c linica l ly a nd b i o ch em i c a ll y p rov e n congeni t a l adrena l hyp e rp l asia (CAH) du e to a 2 1-hy d ro xy l a se def i cie nc y . Bo th o f t he m showed clit o r is h y p e r t rop hy and ab unda ntgrow th o f pu bi c ha ir.Axilla r y sw eat was sampled over a per i od of 24 hour s from thes e children and from normal p r epUbertal c ontrols. Anal ys is showed t hat prepubertal c h i l d r e n e x c r eted n o d ete c table amo unt s of steroi ds , co n t r a s t i n g with t he t wo CAH p ati e nt s . I n axi llary swa et from the la t te r, s i gn ificant le vels of s t e r oi d sul p ha te s were fo und. Th e s te roid moi e t i es o f th e se s ulp h a te d were ma inl y dehy d roepiand r o s t e r one , a n d ro st er one , te st ostero ne an d