Plasma renin activity in normal children

Hiner, Linda B.; Gruskin, Alan B.; Baluarte, H. Jorge; Cote, Mary L.

doi:10.1016/s0022-3476(76)80461-1

Cited by 55 publications

(7 citation statements)

References 8 publications

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“…On the other hand, Joppich & Weber (8) who also reported a significant relationship between PRA and Na excretion (mmoVhour/l.73 m2) in six to nine-hour urines after the blood sampling in infants (1-25 weeks), failed to find such a relationship in Electrolvte and PRA in children 397 older children aged 1 to 14 years. Hiner et al (7) and Van Acker et al (9) did not observe a signifcant correlation between PRA and Na excretion in 24-hour urine, although Goldfarb et al (6) did, but the children in this study were not supine for PRA measurements. This was also suggested by the very high levels of PRA they found.…”

Section: Discussioncontrasting

confidence: 56%

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Electrolyte Excretion in 12‐hour Urine and in Spot Urine

Uchiyama¹,

Otsuka²,

Shibuya³

et al. 1985

Acta Paediatrica

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Plasma renin activity (PRA) and urinary electrolyte excretion were measured in 137 healthy children aged 6 to 14 years. Plasma aldosterone concentration (PAC) was measured in 52 of the children. Nocturnal 12-hour urine was collected in 110 of the children. Spot urine was collected on two occasions, once just before lying down, once after 90-min supine rest in another 27. Na/K ratio and fractional Na excretion rate (FENa) in 12-hour urine showed a significant inverse correlation with PRA or PAC. Na excretion (mmol/min, mmol/mmol creatinine), Na/K ratio and FENa in the spot urine following 90 min in a supine position showed a significant inverse correlation with PRA or PAC, but they failed to show a significant relationship to PRA or PAC in the spot urine preceding supine rest. A spot urine after 90 min in the supine position is collected easily and hence most appropriate to study the relationship between Na excretion and PRA or PAC clinically.

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Section: Discussioncontrasting

confidence: 56%

“…In this context some investigators observed that there is a significant correlation between PRA and urinary Na excretion in adults (2, 3), but others failed to confirm this (4). Only a few studies have been reported in normal children, but the conditions for collecting urine were not constant and results were diverse (5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

Electrolyte Excretion in 12‐hour Urine and in Spot Urine

Uchiyama¹,

Otsuka²,

Shibuya³

et al. 1985

Acta Paediatrica

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“…Furthermore, these products may be important in splanchnic vasoconstrictive responses to stress such as hypoxemia in the maturing animal. Abbreviations AI, angiotensin I AII, angiotensin I1 ACE, angiotensin converting enzyme Aldo, aldosterone HR, heart rate MAP, mean arterial pressure RAA, renin-angiotensin-aldosterone Activity of the renin-angiotensin-aldosterone (RAA) system is increased in newborns in comparison to adults (12, 15, 18-20, 24, 25), and decreases rapidly with increasing postnatal age (6,10,23,25,27,29). Responsiveness of this system may also vary with postnatal age (29).…”

Section: Discussionmentioning

confidence: 99%

Organ Tissue Blood Flow Responses to Hypoxemia in Lambs: Effect of Angiotensin Converting Enzyme Inhibitor

et al. 1983

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SummaryChronically-catheterized lambs (n = 21), 2-38 days of age, were studied to test the hypothesis that the products of angiotensin converting enzyme (ACE) activity are involved in control of baseline arterial pressure and organ tissue blood flow and the redistribution of organ tissue blood flow in response to normocapnic hypoxemia in the maturing lamb. ACE activity was inhibited by administration of captopril 12.5 pg/(kg*min)], which significantly ( P < 0.01) decreased arterial concentrations (mean + S.D.) of angiotensin-I1 (from 105.0 + 33.9 to 67.0 + 25.9 pg/ml) and aldosterone (from 115.0 + 105.0 to 53.8 + 28.6 pg/ml) and inhibited by greater than 90% the vasopressor response to an intravenous bolus of angiotensin-I (1 pg/kg). Baseline mean arterial pressure was significantly ( P < 0.01) decreased from 78 + 8 to 66 + 10 mmHg) and remained depressed during hypoxemia (67 + 12 mmHg) and recovery (62 + 9 mmHg) periods. Baseline heart rate was unchanged by ACE inhibition (from 181 + 33 to 188 + 35 beats/min) but increased ( P < 0.01) significantly in response to hypoxemia (to 233 + 52 beats/min). Baseline heart, adrenal, jejunum, ileum, and skeletal muscle tissue blood flow, measured by radiolabeled microspheres, were not significantly (P > 0.05) changed by ACE inhibitor. Baseline liver tissue blood flow increased slightly [from 0.10 + 0.10 to 0.16 + 0.12 ml/(min*g)] but significantly ( P < 0.05) during ACE inhibitor treatment, and spleen tissue blood flow decreased significantly [from 2.54 + 1.03 to 1.31 + 0.61 ml/(min*g)]. Normocapnic hypoxemia (Poz 42 + 6 torr; oxyhemoglobin saturation 50.7 + 18.0%) for 30 min during ACE inhibition was associated with increased ( P < 0.01) heart [from 2.72 + 1.52 to 8.87 + 5.78 ml/(min*g)] and adrenal [from 2.75 + 1.88 to 6.43 + 2.82 ml/(min*g)l tissue blood flow, decreased (P < 0.01) spleen [from 1. 2.00 ml/(min*g)] demonstrated a greater fall in blood flow to these tissues in response to hypoxemia in control lambs. Thus, the products of ACE may be important in maintenance of baseline arterial pressure in the maturing animal. Furthermore, these products may be important in splanchnic vasoconstrictive responses to stress such as hypoxemia in the maturing animal. Abbreviations AI, angiotensin I AII, angiotensin I1 ACE, angiotensin converting enzyme Aldo, aldosterone HR, heart rate MAP, mean arterial pressure RAA, renin-angiotensin-aldosterone Activity of the renin-angiotensin-aldosterone (RAA) system is increased in newborns in comparison to adults (12, 15, 18-20, 24, 25), and decreases rapidly with increasing postnatal age (6,10,23,25,27,29). Responsiveness of this system may also vary with postnatal age (29). The contribution of this system to the control of organ tissue blood flow in newborn animals is unknown. Furthermore, its importance in pathophysiologic conditions, such as hypoxemia, during maturation is not clear. Activity of RAA system is increased in response to hypoxemia (1,14,22,30,32) and is accompanied by a redistribution of organ tissue arterial blood flow (...

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“…The initial model hypothesized the effects on each dependent variable for 1) age"group; 2) plasma concentration of angiotensin; and 3) a term representing the interaction of plasma concentration of angiotensin and age group. These terms were likewise entered in the model in the above order to provide: 1) an adjustment for variation in overall plasma angiotensin concentrations from age group to age [11][12][13][14][15][16][17][18][19][20] PROCEEDINGS/INTERAMERICAN SOCIETY SUPP II, HYPERTENSION, VOL 3, No 6, NOV/DEC, 1981 group; 2) a test of the main effects of plasma angiotensin concentration; and 3) a final test (homogeneity of slopes) of the possible interaction of plasma angiotensin concentration and age groups.…”

Section: Statisticsmentioning

confidence: 99%