Plasma renin activity and intrarenal blood flow distribution in a child with a pheochromocytoma

Hiner, Linda B.; Gruskin, Alan B.; Baluarte, H. Jorge; Cote, Mary L.; Sapire, David W.; Levitsky, David A.

doi:10.1016/s0022-3476(76)80604-x

Cited by 23 publications

(3 citation statements)

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“…Coexistent phaeochromocytoma and primary aldosteronism is rare enough to warrant the 1998 publication of a case 31 . A literature review in 1976 found that an elevated plasma renin activity had been found in more than 70% of patients with phaeochromocytoma where renin had been measured 32 . Secondary hyperreninaemia and secondary hyperaldosteronism from persistent renal arterial vasoconstriction have been described 33 .…”

Section: Discussionmentioning

confidence: 99%

Twelve‐year Experience in the Investigation and Treatment of Paragangliomas

Tormey

Fitzgerald

Davis

et al. 2002

Int J Clinical Practice

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SUMMARYWe report a 12‐year laboratory experience in the diagnosis of 37 patients with phaeochromocytoma, one with malignant paraganglioma and one with ganglioneuroblastoma. Surgery was performed in eight different hospitals, which underlines the difficulty of ensuring uniformity of investigations. Of the 37 with phaeochromocytoma, 15 were in the right adrenal gland, 12 were on the left, seven were bilateral and three were extra adrenal. Twenty‐three were male and 15 were female; the median age was 36 years. Four of five patients with von Hippel‐Lindau disease had bilateral adrenal tumours and four had neurofibromatosis. None had multiple endocrine neoplasia. Using essential hypertensive patients as a reference population, diagnostic sensitivity was 80% for noradrenaline, 54.4% for adrenaline, 19.1% for dopamine, 93.3% for total normetanephrine, 33.3% for total metanephrine, 78.7% for 3‐methoxy‐4‐hydroxymandelic acid (HMMA) and 23.5% for homovanillic acid (HVA). However, if each patient's results were taken as a package, the sensitivities were 100% for noradrenaline, 63.6% for adrenaline, 30.3% for dopamine and 89% for HMMA. Seven recent patients had gene analysis. There were six (15.4%) deaths due directly or indirectly to the paraganglioma. Postoperative blood pressures were normal in 74%. The decrement in catecholamine values post‐surgery is shown. Urinary noradrenaline values fell by a mean of 94.5% and the use of urinary noradrenaline as a tumour marker is also demonstrated.

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Section: Discussionmentioning

confidence: 99%

Twelve‐year Experience in the Investigation and Treatment of Paragangliomas

Tormey

Fitzgerald

Davis

et al. 2002

Int J Clinical Practice

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“…Evaluation at relapse showed the reappearance of hyperaldosteronism associated with elevated renin activity. It has previously been shown that plasma renin levels are often increased in patients with paraganglionoma or phaeochromocytoma (Hiner et al., 1976), and that catecholamines per se stimulate the release of renin. This mechanism did not seem to explain the increased levels of renin in this patient as 24 h urine catecholamine levels (Table 1 legend) were essentially normal throughout the course of the disease.…”

Section: Discussionmentioning

confidence: 99%

Malignant human renin producing paraganglionoma–localization with ¹²³I‐MIBG and treatment with ¹³¹I‐MIBG

Arver

Jacobsson

Cedermark³

et al. 1999

Clinical Endocrinology

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A 22-year-old woman presenting severe hypertension and hypokalaemia is described. Initial evaluation showed a large tumour localized at the position of the left adrenal gland. Subsequent surgery temporarily relieved all signs and symptoms caused by the tumour. The symptoms relapsed after a 2-year disease-free interval. At re-evaluation, the tumour was shown to produce an uncontrolled secretion of renin, thus triggering aldosterone-dependent hypertension. This report describes the diagnosis, treatment and clinical course of this unique patient with a malignant paraganglionoma of adrenal origin.

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“…Possible mechanisms include direct effect of norepinephrine on juxtarglomerular cells [2], redistribution of intrarenal blood flow [3], concomitant renal artery lesions [4,5], either due to direct compression by tumors, atherosclerosis, or fibromuscular hyperplasia and transient vasospasm during catecholamine crisis [6]. In this patient, the extremely high plasma renin level was transient and all image studies excluded the existence of fixed renal or coronary artery stenosis.…”

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confidence: 99%

Adrenal pheochromocytoma associated with transient hyperreninemia

Cheng

Wang

Huang

et al. 2006

International Journal of Cardiology

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Plasma renin activity and intrarenal blood flow distribution in a child with a pheochromocytoma

Cited by 23 publications

References 12 publications

Twelve‐year Experience in the Investigation and Treatment of Paragangliomas

Twelve‐year Experience in the Investigation and Treatment of Paragangliomas

Malignant human renin producing paraganglionoma–localization with ¹²³I‐MIBG and treatment with ¹³¹I‐MIBG

Adrenal pheochromocytoma associated with transient hyperreninemia

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Plasma renin activity and intrarenal blood flow distribution in a child with a pheochromocytoma

Cited by 23 publications

References 12 publications

Twelve‐year Experience in the Investigation and Treatment of Paragangliomas

Twelve‐year Experience in the Investigation and Treatment of Paragangliomas

Malignant human renin producing paraganglionoma–localization with 123I‐MIBG and treatment with 131I‐MIBG

Adrenal pheochromocytoma associated with transient hyperreninemia

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Malignant human renin producing paraganglionoma–localization with ¹²³I‐MIBG and treatment with ¹³¹I‐MIBG