Plasma renin activity and hypertrophy of the right ventricle in hypoxic rats

Kentera, D.; Sušić, Dinko; Cemerikic, Dusan

doi:10.1007/bf01908396

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…The degree of hypoxic hypertrophy of the right ventricle paralleled to some extent the changes in PRA induced by difference in salt intake as was shown previously (4). Inhibition of conversion of angiotensin I into angiotensin II is also followed by a decrease in hypertrophy of the right ventricle in hypoxic rats.…”

Section: Discussionsupporting

confidence: 61%

“…However, some of the recent reports indicate that the renin-angiotensin system may play at least a permissive role in the development of left ventricular hypertrophy in various models of experimental hypertension (1,2,3). Furthermore, a previous report from our laboratory (4), showing that suppression of the activity of the renin-angiotensin system by salt overload abolishes hypertrophy of the right ventricle in chronically hypoxic rats, has given further support to this notion. However, pulmonary artery pressure was not measured in this study.…”

mentioning

confidence: 74%

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Effects of SQ 14.225, an orally active inhibitor of angiotensin-converting enzyme, on hypoxic pulmonary hypertension and right ventricular hypertrophy in rats

et al. 1981

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Treatment with SQ 14.225, an inhibitor of the enzyme converting angiotensin I to angiotensin II and lowering of plasma renin activity by dietary salt overload, significantly decreased hypertrophy of the right ventricle in chronically hypoxic rats. The smaller degree of right ventricular hypertrophy registered in hypoxic rats with suppressed activity of the renin-angiotensin system was proportional to the decrease in hypoxic pulmonary hypertension noted in these animals. Lowering of pulmonary hypertension in chronically hypoxic rats by suppression of the renin-angiotensin system is consistent with the idea that angiotensin II may be involved in eliciting hypoxic pulmonary vasoconstriction. Inhibition of converting enzyme also lowered the systemic arterial pressure in hypoxic rats, but this finding could not be taken as evidence for the role of the renin-angiotensin system in homeostatic control of blood pressure in normal animals, since the plasma-renin activity in hypoxic rats is increased and the blood pressure higher than in rats kept under normoxic conditions.

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Section: Discussionsupporting

confidence: 61%

mentioning

confidence: 74%

Effects of SQ 14.225, an orally active inhibitor of angiotensin-converting enzyme, on hypoxic pulmonary hypertension and right ventricular hypertrophy in rats

et al. 1981

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“…The effects of hypoxia on renin secretion, as reflected by the plasma renin activity (PRA), are less clear, and data on renal renin gene expression are scarce [2][3][4][5][6][7][8][9][10]. The influence of hypoxia on renin secretion may be modulated by sodium balance [3,11]. Most studies suggest that acute hypoxia causes natriuresis, which may return to the normal or subnormal range during prolonged exposure [7,12,13].…”

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confidence: 99%

Effects of hypoxia on renin secretion and renal renin gene expression

Krämer

Ritthaler

Schweda

et al. 1998

Kidney International

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Effects of hypoxia on renin secretion and renal renin gene expression. Plasma renin activity (PRA) and renal renin mRNA levels were measured in male rats exposed to hypoxia (8% O 2 ) or to carbon monoxide (CO; 0.1%) for six hours. PRA increased fourfold and 3.3-fold, and renin mRNA levels increased to 220% and 200% of control, respectively. In primary cultures of renal juxtaglomerular (JG) cells, hypoxia (lowering medium O 2 from 20% to 3% or 1%) for 6 or 20 hours did not affect renin secretion or gene expression. Renal denervation did not prevent stimulation of the renin system by hypoxia. Because norepinephrine increased 1.7-fold and 3.2-fold and plasma epinephrine increased 3.9-fold and 7.8-fold during hypoxia and CO inhalation, respectively, circulating catecholamines might mediate the stimulatory effects of hypoxia on renin secretion and renin gene expression. Stimulation of ␤-adrenergic receptors by continuous infusion of 160 g/kg/hr isoproterenol increased PRA 17-fold and 20-fold after three and six hours, respectively, and renin mRNA by 130% after six hours. In rats with a stimulated renin system (low-sodium diet), isoproterenol did not stimulate PRA or renal renin mRNA further. In summary, both arterial and venous hypoxia can stimulate renin secretion and renin gene expression powerfully in vivo but not in vitro. These effects seem not to be mediated by renal nerves or by a direct effect on JG cells but might be mediated by circulating catecholamines.

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“…Its main function is to stimulate the mitosis of endothelial cells. In the ovary, VEGFA was expressed in both granulosa cells and follicles as ovulation approached, and the expression of VEGFA in granulosa cells was significantly increased [45]. Meanwhile, some evidence shows that VEGFA plays an important role in follicular survival and inhibition of granulosa cell apoptosis [46].…”

Section: Discussionmentioning

confidence: 99%

Effect of Concentrate Supplementation on the Expression Profile of miRNA in the Ovaries of Yak during Non-Breeding Season

Xie

Kalwar

Yan

et al. 2020

Animals

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Yak (Bos grunniens) is an important and remarkable livestock species that survives in the challenging environment of the Qinghai–Tibetan Plateau. However, its growth rate is slower and reproductive potential is generally lower than cattle. Meanwhile, it has been reported that enhanced nutrition improves the reproductive efficiency of animals. The purpose of this study was to investigate the effect of concentrate supplementation on the miRNA expression profile in the ovaries of yak during the non-breeding season. The study displayed that non-breeding season supplementation significantly improved growth performance, serum biochemical indicators, and reproductive hormone concentrations in yaks. In this study, we also examined the differential expression analysis of miRNA in the ovaries of yak during non-breeding seasons using Illumina Hiseq sequencing technology. As a result, 51 differentially expressed miRNAs were found in the experimental group (CS) and control group (CON). Gene Ontology (go) and Kyoto Genome Encyclopedia (KEGG) analysis of target genes showed that beta-alanine metabolism; tryptophan metabolism; sphingolipid metabolism; alanine, aspartate and glutamate metabolism; and the inositol phosphate metabolism pathway attracted our attention. Based on qRT-PCR, seven miRNAs were assessed to verify the accuracy of the library database. We predicted and identified potential miRNA target genes, including LEP, KLF7, VEGFA, GNAQ, GTAT6, and CCND2. miRNA and corresponding target genes may regulate yaks’ seasonal reproduction through their nutritional status. This study will provide an experimental basis for improving the reproductive efficiency of yaks by supplementation in the non-breeding season.

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Plasma renin activity and hypertrophy of the right ventricle in hypoxic rats

Cited by 6 publications

References 7 publications

Effects of SQ 14.225, an orally active inhibitor of angiotensin-converting enzyme, on hypoxic pulmonary hypertension and right ventricular hypertrophy in rats

Effects of SQ 14.225, an orally active inhibitor of angiotensin-converting enzyme, on hypoxic pulmonary hypertension and right ventricular hypertrophy in rats

Effects of hypoxia on renin secretion and renal renin gene expression

Effect of Concentrate Supplementation on the Expression Profile of miRNA in the Ovaries of Yak during Non-Breeding Season

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