1953
DOI: 10.1016/s0065-230x(08)60010-x
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Plasma Proteins in Cancer

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1955
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Cited by 55 publications
(12 citation statements)
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“…Cachexia is, in turn, seen to be associated with hypoalbuminemia, a feature which has been observed by several previous workers (Ariel, 1949;Winzler, 1953;Peden et al, 1957).…”
Section: Discussionsupporting
confidence: 74%
“…Cachexia is, in turn, seen to be associated with hypoalbuminemia, a feature which has been observed by several previous workers (Ariel, 1949;Winzler, 1953;Peden et al, 1957).…”
Section: Discussionsupporting
confidence: 74%
“…These have been found primarily in the quantitative and qualitative composition of the serum proteins (reviewed by Winzler, 1953, andPetermann, 1961). Changes in tumour sera which may cause agglutination of tumour cells have not previously been reported.…”
Section: Discussionmentioning
confidence: 99%
“…Thus Sato, Amizuka and Sato (1962) have found that the non-specific agglutination of kieselguhr by human serum is quantitatively inhibited by increasing additions of human seromucoid. It is established that in cancer there is an elevation in serum seromucoid (Winzler, 1953). If this component plays a role in the HeLa cell agglutination system, it is possible that failure to obtain agglutination in some cancer sera (Table I) may have been due to an excessive elevation of this serum component.…”
Section: Discussionmentioning
confidence: 99%
“…We assume that this increased amount of albumin is repaid from some reserves of this protein in these early stages. Good (Winzler, 1953) providing evidence that such a transformation may exist in other tumour tissues, too. For the early stages of tumour growth, however, a general mobilization of protein metabolism must be taken into account in explaining the higher turn-over rate of serum albumin.…”
Section: Discussionmentioning
confidence: 99%