“…Discovery of novel biomarkers has recently been accelerated by the use of highthroughput proteomics. In this issue of JASN, Kim et al 1 employ aptamer-based proteomics on human plasma samples paired with biopsies from the Boston Kidney Biopsy Cohort to discover biomarkers of specific lesions on kidney biopsy. These efforts aim at enabling noninvasive evaluation of histopathology that may help defer kidney biopsy in certain clinical contexts.…”