Plasma protein changes in horse after prolonged physical exercise: A proteomic study

Serum amyloid A, haptoglobin, and ferritin in horses with colic: Association with common clinicopathological variables and short-term outcome

“…Haemolysis or muscle fibre lysis associated with colic may explain the latter result, since the main biological function of haptoglobin is to bind free haemoglobin and myoglobin, reducing their serum concentrations (Schaer et al, 2013). In particular, the haptoglobinhaemoglobin complex reduces or eliminates the oxidative potential of haemoglobin and prevents the subsequent formation of ironderived reactive oxygen species (Sakata et al, 1986;Borges et al, 2007;Crisman et al, 2008;Nielsen et al, 2010;Scoppetta et al, 2012). A recent study supported this result in horses with colic (Pihl et al, 2013).…”

“…Bound to haptoglobin, haemoglobin and myoglobin remain sequestered within the intravascular space and endothelial or renal tubular cell damage is prevented. The removal of haptoglobin-haemoglobin/myoglobin complexes by the liver results in a rapid decrease in plasma haptoglobin concentration (Scoppetta et al, 2012;Schaer et al, 2013).…”

Serum iron, ferritin, transferrin and haptoglobin concentration variations during repeated show jumping competition in horse

“…Several studies carried out in athletic horses showed that physical exercise of different intensities and durations influence iron homeostasis (Mills et al 1996;Karamizrak et al 1996;Inoue et al 2005;Scoppetta et al 2012). It is noteworthy that iron depletion could influence athletic performance through low haemoglobin concentration with a consequent reduction in the oxygen transport capacity, decreasing the maximal oxygen uptake (Walker et al 2001).…”

Proteomics in Animal Health and Production

“…Most of these changes occurred immediately after the race and returned to control values with in 24/48 hrs and it is considered as a prompt adaptation to stressful end (68).…”