“…But each also remains curiously under-represented in mainstream GxE research today. This is despite evidence to suggest they may serve a functional purpose as biomarkers of environmentally-induced pathogenesis, susceptibility, illness progression and treatment outcome [146][147][148][149][150][151][152] . Despite these documented examples, each discipline also faces thematic questions about how to achieve methodological best practice, given their various respective constraints 147,153,154 .…”