Plasma pro- and anti-inflammatory cytokines may relate to cocaine use, cognitive functioning, and depressive symptoms in cocaine use disorder

Stamatovich, Sydney N.; Lopez-Gamundi, Paula; Suchting, Robert; Colpo, Gabriela Delevati; Walss‐Bass, Consuelo; Lane, Scott D.; Schmitz, Joy M.; Wardle, Margaret C.

doi:10.1080/00952990.2020.1828439

Cited by 14 publications

(9 citation statements)

References 75 publications

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“…Serum concentrations of IL-4 and IFN-γ both decreased after cocaine and haloperidol treatment; however, due to considerable inter-individual variability, we did not find the effects to be statistically significant. Results suggest that, for some individuals, haloperidol and cocaine may suppress IL-4 and IFN-γ signaling [18,55]. Moreover, the concentrations of IL-4 and IFN-γ that we detected in our study were comparable to that of control groups in other reports [56,57], suggesting that manipulations of chronically implanted catheters per se did not induce pronounced inflammation.…”

Section: Discussionsupporting

confidence: 79%

Intravenous haloperidol and cocaine alter the distribution of T CD4⁺ and B lymphocytes and NKT cells in rats

Jankowski

Ignatowska‐Jankowska

Glac

et al. 2021

Preprint

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Modulation of dopamine transmission evokes strong behavioral effects that can be achieved by psychoactive drugs such as haloperidol or cocaine. Cocaine non-specifically increases dopamine transmission by blocking dopamine active transporter (DAT) and evokes behavioral arousal, while haloperidol is a non-specific dopamine D2 receptor antagonist with sedative effects. Interestingly, dopamine has been found to affect immune cells in addition to its action in the central nervous system. Here we address the possible interactions between haloperidol and cocaine and their effects on both immune cells and behavior in freely moving rats. We use an intravenous model of haloperidol and binge cocaine administration to evaluate the drugs’ impact on the distribution of lymphocyte subsets in both the peripheral blood and the spleen. We assess the drugs’ behavioral effects by measuring locomotor activity. Cocaine evoked a pronounced locomotor response and stereotypic behaviors, both of which were completely blocked after pretreatment with haloperidol. The results suggest that blood lymphopenia which was induced by haloperidol and cocaine (except for NKT cells), is independent of dopaminergic activity and most likely results from the massive secretion of corticosterone. Haloperidol pretreatment prevented the cocaine-induced decrease in NKT cell numbers. On the other hand, the increased systemic dopaminergic activity after cocaine administration is a significant factor in retaining T CD4+ and B lymphocytes in the spleen.Abstract Figure

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Section: Discussionsupporting

confidence: 79%

Intravenous haloperidol and cocaine alter the distribution of T CD4⁺ and B lymphocytes and NKT cells in rats

Jankowski

Ignatowska‐Jankowska

Glac

et al. 2021

Preprint

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“…Many of findings were contrary to expectations that higher pro-inflammatory markers would relate to more frequent METH use, stronger craving and more severe negative affect (i.e., depression and anxiety) while higher anti-inflammatory cytokines would relate to less frequent METH use, lower craving and less severe negative affect. These rather disturbing results might indicate a more complex relationship between immune system activity and addiction as mentioned by ( Stamatovich et al., 2021 ) in a previous study of cocaine use disorder, possibly distinct across different periods of substance use.…”

Section: Discussionmentioning

confidence: 80%

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Deng

Song

et al. 2021

Front. Cell. Infect. Microbiol.

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Methamphetamine use disorder (MUD) is a major public health problem worldwide with limited effective treatment options. Previous studies have reported methamphetamine-associated alterations in gut microbiota. A potential role of gut microbiota in regulating methamphetamine-induced brain dysfunction through interactions with the host immune system has been proposed, but evidence for this hypothesis is limited. The present study aimed to investigate the alterations in the fecal microbiota and explore its relationship with systemic inflammation in MUD. Fecal samples were obtained from 26 male subjects with MUD and 17 sex- and age- matched healthy controls. Fecal microbial profiles were analyzed by 16S rRNA sequencing. Plasma inflammatory markers were measured using enzyme-linked immunosorbent assay. Associations between fecal microbiota, systemic inflammatory markers and clinical characteristics were examined by Spearman partial correlation analysis while controlling for possible confounders. Compared with healthy controls, individuals with MUD showed no difference in fecal microbial diversity, but exhibited differences in the relative abundance of several microbial taxa. At the genus level, a higher abundance of Collinsella, Odoribacter and Megasphaera and lower levels of Faecalibacterium, Blautia, Dorea and Streptococcus were detected in subjects with MUD. More importantly, altered fecal microbiota was found to be correlated with plasma levels of CRP, IL-2, IL-6 and IL-10. The order Lactobacillales, exhibiting lower abundance in participants with MUD, was positively related to the duration of methamphetamine abstinence and the plasma level of anti-inflammatory cytokine IL-10. This study is the first to provide evidence for a link between altered fecal microbiota and systemic inflammation in MUD. Further elucidation of interactions between gut microbiota and the host immune system may be beneficial for the development of novel therapeutic approaches for MUD.

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“…It was shown that a higher plasmatic IL-6 level is associated with lower cognitive flexibility, assessed by the Wisconsin CARD Sorting Test (itself previously associated with the risk of relapse) [ 67 ]. In a more recent study, a longer duration of cocaine use was associated with lower IL-9 and IL-20 levels [ 70 ]. Concerning IL-1β, lower plasmatic levels were observed in CUD patients with at least two weeks of abstinence compared with healthy controls [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

Biomarkers of Relapse in Cocaine Use Disorder: A Narrative Review

et al. 2022

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Introduction: Cocaine use disorder is a chronic disease with severe consequences and a high relapse rate. There is a critical need to explore the factors influencing relapse in order to achieve more efficient treatment outcomes. Furthermore, there is a great need for easy-to-measure, repeatable, and valid biomarkers that can predict treatment response or relapse. Methods: We reviewed the available literature on the Pubmed database concerning the biomarkers associated with relapse in CUD, including central nervous system-derived, genetic, immune, oxidative stress, and “other” biomarkers. Results: Fifty-one articles were included in our analysis. Twenty-five imaging brain anatomic and function assessment studies, mostly using fMRI, examined the role of several structures such as the striatum activity in abstinence prediction. There were fewer studies assessing the use of neuropsychological factors, neurotrophins, or genetic/genomic factors, immune system, or oxidative stress measures to predict abstinence. Conclusion: Several biomarkers have been shown to have predictive value. Prospective studies using combined multimodal assessments are now warranted.

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Plasma pro- and anti-inflammatory cytokines may relate to cocaine use, cognitive functioning, and depressive symptoms in cocaine use disorder

Cited by 14 publications

References 75 publications

Intravenous haloperidol and cocaine alter the distribution of T CD4⁺ and B lymphocytes and NKT cells in rats

Intravenous haloperidol and cocaine alter the distribution of T CD4⁺ and B lymphocytes and NKT cells in rats

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Biomarkers of Relapse in Cocaine Use Disorder: A Narrative Review

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Plasma pro- and anti-inflammatory cytokines may relate to cocaine use, cognitive functioning, and depressive symptoms in cocaine use disorder

Cited by 14 publications

References 75 publications

Intravenous haloperidol and cocaine alter the distribution of T CD4+ and B lymphocytes and NKT cells in rats

Intravenous haloperidol and cocaine alter the distribution of T CD4+ and B lymphocytes and NKT cells in rats

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder

Biomarkers of Relapse in Cocaine Use Disorder: A Narrative Review

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Product

Resources

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Intravenous haloperidol and cocaine alter the distribution of T CD4⁺ and B lymphocytes and NKT cells in rats

Intravenous haloperidol and cocaine alter the distribution of T CD4⁺ and B lymphocytes and NKT cells in rats