Plasma poration: Transdermal electric fields, conduction currents, and reactive species transport

Wu, Eric Q.; Nie, Lanlan; Liu, Dawei; Lü, Xing; Ostrikov, Kostya

doi:10.1016/j.freeradbiomed.2023.02.011

Cited by 10 publications

(3 citation statements)

References 37 publications

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“…As these perforations are small, they heal and close rapidly, allowing for effective drug delivery [112]. The technique is pain-free, unlike traditional electroporation approaches [113]. A wide range of therapeutics have now been shown to be compatible with this approach [114], and that list continues to grow [115].…”

Section: Combinations Of Plasma With Traditional Pharmaceuticalsmentioning

confidence: 99%

“…Recent studies have focused on the use of plasma-treated hydrogels to deliver prolonged transdermal drug delivery. Early studies indicate that the choice of hydrogel is important in controlling the drug delivery properties of the treated gel [113]. A related feature was the emergence of drug delivery hydrogels that had been plasma-treated.…”

Section: Combinations Of Plasma With Traditional Pharmaceuticalsmentioning

confidence: 99%

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Recent Developments in the Use of Plasma in Medical Applications

O’Neill,

Bourke

2024

Plasma

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A detailed review of the scientific literature was undertaken to examine the most recent developments in plasma processing in the field of medicine. The first part of the review includes a detailed breakdown of the different types of coatings that can be applied onto medical devices using plasma, with a specific focus on antimicrobial surfaces. The developments in plasma-deposited biocompatibles, drug delivery and adhesive coatings in 2023 are described, and specific applications in additive manufacturing are highlighted. The use of plasma and plasma-activated liquids as standalone therapeutics continues to evolve, and pertinent advances in this field are described. In addition, the combination of plasma medicine with conventional pharmaceutical interventions is reviewed, and key emerging trends are highlighted, including the use of plasma to enhance drug delivery directly into tissue. The potential synergies between plasma medicine and chemotherapeutics for oncology and infection treatment are a growing area, and recent advancements are noted. Finally, the use of plasma to control excess antibiotics and to intentionally degrade such materials in waste streams is described.

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Section: Combinations Of Plasma With Traditional Pharmaceuticalsmentioning

confidence: 99%

Section: Combinations Of Plasma With Traditional Pharmaceuticalsmentioning

confidence: 99%

Recent Developments in the Use of Plasma in Medical Applications

O’Neill,

Bourke

2024

Plasma

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“…[ 4 ] In practical terms, plasma represents an exogenous source of reactive oxygen and nitrogen species (RONS), generated following interaction with ambient air, that play an important role in cell physiology and pathology. [ 5–7 ] Plasma also interacts with surrounding molecules from the air, liquid, or the (biological) target [ 8 ] that results in a complex cocktail of RONS [ 9,10 ] comprising highly reactive short‐lived species such as ·O, ·OH, and ·NO and more stable, long‐lived species, e.g., H 2 O 2 and NO 2 − . In high concentrations, RONS can irreversibly alter biomolecules and lead to cell death.…”

Section: Introductionmentioning

confidence: 99%

Injectable Plasma‐Treated Alginate Hydrogel for Oxidative Stress Delivery to Induce Immunogenic Cell Death in Osteosarcoma

Živanić,

Espona‐Noguera,

Verswyvel

et al. 2023

Adv Funct Materials

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Cold atmospheric plasma (CAP) is a source of cell‐damaging oxidant molecules that may be used as low‐cost cancer treatment with minimal side effects. Liquids treated with cold plasma and enriched with oxidants are a modality for non‐invasive treatment of internal tumors with cold plasma via injection. However, liquids are easily diluted with body fluids which impedes high and localized delivery of oxidants to the target. As an alternative, plasma‐treated hydrogels (PTH) emerge as vehicles for the precise delivery of oxidants. This study reports an optimal protocol for the preparation of injectable alginate PTH that ensures the preservation of plasma‐generated oxidants. The generation, storage, and release of oxidants from the PTH are assessed. The efficacy of the alginate PTH in cancer treatment is demonstrated in the context of cancer cell cytotoxicity and immunogenicity–release of danger signals and phagocytosis by immature dendritic cells, up to now unexplored for PTH. These are shown in osteosarcoma, a hard‐to‐treat cancer. The study aims to consolidate PTH as a novel cold plasma treatment modality for non‐invasive or postoperative tumor treatment. The results offer a rationale for further exploration of alginate‐based PTHs as a versatile platform in biomedical engineering.

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