Plasma polymers from oregano secondary metabolites: Antibacterial and biocompatible plant‐based polymers

Abstract

Bacterial infection of chronic wounds is a major healthcare problem that affects the quality of life of millions of patients worldwide and leads to a substantial healthcare cost burden. This project focused on the manufacture of a potential wound healing agent. Plasma polymers from oregano secondary metabolites (PP-OSMs) were fabricated by radiofrequency plasma-enhanced chemical vapor deposition (RF-PECVD) in continuous and pulse plasma modes at room temperature. The surface, biocompatibility, and antibacterial properties of the PP-OSMs were investigated. Polymers fabricated by RF-PECVD retained the functional groups of OSMs, promoted human dermal fibroblast adhesion, inhibited Staphylococcus aureus attachment, and eliminated Pseudomonas aeruginosa. The PP-OSM coatings are potential candidates for use in medical applications where cell biocompatibility and antibacterial properties are required.

Eucalyptus globulus essential oil thin film polymerized by cold plasma on Ti6Al4V: Sterilization effect, antibacterial activity, adhesion, and viability of mesenchymal stem cells

“…After film deposition, more than one behavior is observed in relation to surface roughness. Thin coatings applied to smooth glass surfaces exhibit similar behavior, [71][72][73] as observed in this work, decreasing the mean nanometric roughness values (R a = 2 nm) of the surface in relation to the substrate (R a = 4 nm). In the microscale roughness, there was no significant difference in the R a values.…”

Plasma polymerization of biogenic precursors

“…The plasma polymers showed antibacterial activity against S. aureus and P. aeruginosa whilst supporting human dermal fibroplast adhesion. [94] Considering essential oil-based plasma polymers, it is important to remember that essential oils are natural products whose composition may vary from batch to batch. Results from different research works can therefore not be easily compared and may not always be entirely reproducible with materials from different suppliers or batches.…”

“…The plasma polymers showed antibacterial activity against S. aureus and P. aeruginosa whilst supporting human dermal fibroplast adhesion. [ 94 ]…”

Special issue: Plasmas for Biointerfaces

“…Kruse et al [ 5 ] describe an in vivo ovine osteointegration study on 3D‐printed polyether‐ether‐ketone (PEEK) bone implants surface‐modified by means of a plasma immersion ion implantation process. The issue of coatings deposited by aerosol‐assisted AP plasma processes for controlled release of molecules is addressed by Morand et al, [ 6 ] while that of antibacterial plasma polymers based on natural molecules is discussed by Romo Rico et al [ 7 ] Two papers on plasma processing of scaffolds, by Solovieva et al [ 8 ] for enhancing wound healing in diabetic mice, and by Redzikultsava et al [ 9 ] on processes and scaffold design principles, round off this special issue.…”